Immunity – Page 34

LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation

3 de March de 202413 de February de 2024 by Nicole Joller, Ana C. Anderson, Vijay K. Kuchroo

LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint receptors being harnessed in the clinic.In this review, Joller et al. review advances in our understanding of the specialized functions of LAG-3, TIM-3, and TIGIT, focusing on th…

Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging

22 de January de 202422 de January de 2024 by Zhao Zhou, Jingfei Yao, Dongmei Wu, Xun Huang, Yushuang Wang, Xinmeng Li, Qiang Lu, Yifu Qiu

Aging induces cellular senescence of immune cells, yet the underlying mechanism is poorly understood. Here, Zhou et al. reveal that type 2 cytokine signaling protects macrophages from senescence by directly sustaining DNA repair. They further show that…