CD8+ T cells integrate signals from the local microenvironment to establish tissue residency, but which factors are involved and how remain unresolved. Obers et al. highlight the role of retinoic acid (RA) in promoting TRM cell formation across multipl…
Mechanisms that support long-term CD4+ T cell persistence and function in the face of chronic autoimmune stimulus remain unresolved. Aljobaily et al. demonstrate that epigenetic programming and retention of low TCF1 expression promote autoimmune CD4+ T…
The role of tumor-associated macrophages (TAMs) in pediatric high-grade glioma (pHGG) remains highly understudied. Ross et al. find that tumor driver mutations uniquely shape the immune infiltrate and transcriptional profiles of TAMs. Interferon signal…
The meningeal lymphatics system plays diverse roles in facilitating neuroimmune function at brain borders, yet its specific contribution toward glial function and homeostasis is not known. In this issue of Immunity, Das Neves et al. (2024) describe a n…
PD-1 blockade partially reverses T cell exhaustion in cancer patients, but broad responses are still limited. Three studies recently published in Cell illuminate how abrogating LAG-3 and PD-1 synergize to further push effector T cell functionality via …
Although the precise identities of the APCs that induce peripheral Treg cells and most effector T cell subsets continue to be debated, what is clear is that the microbiota direct the differentiation of distinct CD4+ T cell programs by delivering antige…
It’s crucial for skin to establish efficient defense strategies. Liu et al. reveal that the transcription factor ZNF750 recruits the histone demethylase KDM1A to silence pattern recognition receptors in the outer epidermis, making their expression limi…
Understanding the factors that lead to the therapeutic success of adoptive cell therapies using tumor-infiltrating lymphocytes (TIL-ACT) will improve current treatment protocols. In this issue of Immunity, Chiffelle et al. comprehensively compare the d…
Understanding the nature of human autoantigen-specific CD4+ T cells is limited by the difficulty of characterizing these cells ex vivo. In this issue of Immunity, Saggau et al. use ARTE technology to profile CD4+ T cells specific to disease-relevant au…
SLE is an interferonopathy, but blocking IFN does not benefit all patients. Caielli et al. found that SLE monocytes co-produce IFN and IL-1β, a phenotype recapitulated upon in vitro Mito+ RBC opsonization. Cytosolic sensing of mitochondrial nucleic aci…
