Particle exposure drives inflammation through unknown regulatory mechanisms. Cobo et al. identified a bifurcated transcriptional response in macrophages: an AMPK-TFEB/TFE3-DNMT3A/DOT1L axis controlling lysosomal acidification and a JNK-AP-1 pathway dri…
(Immunity 50, 418–431.e1–e6; February 19, 2019)
Central nervous system malignancies include primary tumors and brain metastases (BrMs) originating from extracranial cancers. Bejarano et al. examine primary and metastatic brain tumors and find distinct vascular alterations in IDH mutant gliomas, IDH …
Memory B cells (MBCs) emerging from germinal centers (GCs) are crucial for antibody-based vaccines. Luo, Hou, et al. find that T cell-derived interleukin-9 promotes expression of the transcriptional repressor ZBTB18 in GC B cells. ZBTB18 represses the …
VEGF blockade is known to enhance immune checkpoint blockade (ICB) efficacy, but its precise immunological mechanism remains undefined. Benmebarek et al. reveal that VEGF inhibition drives BAFF- and IL-12-dependent Treg reprogramming, promoting a fragi…
Lactate shows immunomodulatory properties. Mauro et al. review how lactate serves a fuel for the TCA cycle and an immunomodulatory molecule with context-dependent effects, and how its immunomodulatory properties are mediated via sensing through transpo…
CRISPR screens are widely utilized to identify genes that regulate immune function or mediate sensitivity of cancer cells to immune attack. In this issue of Immunity, Zeng et al. present a computational framework for uncovering gene targets with dual f…
Hepatocellular carcinoma is poorly responsive to immune checkpoint blockade. In a recent issue of Science, Varanasi et al. reveal how bile acids dampen anti-tumor CD8+ T cell responses in the liver, contributing to cancer progression and poor immunothe…
Receptor interaction kinase 3 (RIPK3) is a key mediator of necroptosis, initiating programmed cell death with mercenary efficiency in multiple neurodegenerative diseases. However, in this issue of Immunity, Estevez et al. demonstrate that RIPK3, like t…
Neuroimmune regulation modulates responses to cardiovascular stress and injury. In this issue of Immunity, Perrotta et al. delineate a heart-brain-spleen axis that induces adaptive cardiac remodeling in response to pressure overload, highlighting a SPe…
