How T cells are recruited to brain tumors from the blood remains unclear. Messmer et al. identify peritumoral venous vessels (PVVs) as key structures for T cell recruitment to melanoma brain tumors. PVVs are the sites of T cell extravasation and facili…
Whether and how ILC2s regulate airway neutrophil infiltration during asthma is unknown. Rao et al. show that ILC2s release HMGB1-loaded lipid droplets to induce neutrophil infiltration into the airway, demonstrating the crucial functions of extracellul…
The therapeutic potential of antigen-independent innate immune memory (IIM) is of particular relevance in the context of respiratory viruses with pandemic potential. Lercher et al. find that antiviral IIM in alveolar macrophages following SARS-CoV-2 in…
It is unclear why the surface of the skin, which constantly encounters pro-inflammatory stimuli, is not always inflamed. Liu et al. show that as differentiated keratinocytes migrate toward the surface of the skin, they turn off the expression of patter…
Identifying human T cells that have recently emigrated from the thymus remains problematic. Here, Bohacova et al. categorize recent thymic emigrants with high CD38 expression as their universal surface marker. Additionally, they explore the transcripti…
How p53 modulates the immune landscape for immune escape remains elusive. Nian et al. report that p53 inactivation results in IL-34 secretion by CSCs, and IL-34-CD36-axis-orchestrated TAMs promote tumor immune escape by suppressing T cell-mediated anti…
Liver macrophages, including Kupffer cells and monocyte-derived macrophages, play diverse roles in liver diseases. However, the mechanisms underlying their differentiation and functions in MASLD/MASH are not well understood. Guo et al. reveal that Notc…
Antibodies that protect us from pathogens also influence how the immune system responds to infection or vaccination. Dvorscek et al. reveal a mechanistic framework of how antibodies can optimize protective immunity, regulating B cell response participa…
Insight into how the immune system recognizes and responds to pathogens had led to landmark advances in biology and medicine in the last decades. This year’s Albert Lasker Award for Basic Medical Research honors Zhijian “James” Chen for the discovery o…
TIR-domain proteins with enzymatic activity are essential for immunity across the tree of life. Tse-Kang et al. show that C. elegans TIR-1 is a guard protein in an effector-triggered immune response, which enables intestinal epithelial cells to survey …
