The neurophysiological processes regulated by meningeal lymphatic function remain unclear. das Neves et al. showed that meningeal lymphatic dysfunction leads to loss of mature oligodendrocytes and demyelination in the brain. Defective meningeal lymphat…
T cells drive islet destruction in autoimmune diabetes. Mitchell et al. find that CD4+ T cells specific for a hybrid peptide derived from insulin C and chromogranin A skewed toward a distinct Th1 phenotype and were primed by XCR1+ dendritic cells early…
Th1 CD4+ T cells mediate protective anti-Mtb immunity across biological systems and organisms. Bromley, Ganchua, et al. demonstrate that CD4+ T cells regulate immune tone in TB granulomas and are necessary for immune recall and protection against reinf…
The tumor microenvironment promotes metabolic reprogramming of tumor-infiltrating immune cells. Ping, Shan, Qin, et al. examine phospholipid metabolism in the TME and find an altered phospholipid profile in intratumoral CD8+ T cells. These alterations …
Memory B cells dominate recall responses, but how they react to novel antigens is not well understood. Li and Obraztsova et al. show that MBCs with similar antigen reactivity as those of naive B cells rapidly differentiate into ASCs without signs of ge…
Predicting antibody specificity based solely on sequence has remained an obstacle in humoral research. Leveraging a curated dataset of >5,000 influenza hemagglutinin (HA) antibodies, Wang et al. develop a lightweight memory B cell language model for an…
The BCG vaccine for tuberculosis protects against non-mycobacterial infections, but the mechanisms are unclear. Sun et al. found that BCG alters gene expression and chromatin accessibility in hematopoietic stem and progenitor cells (HSPCs), predicting …
Little is known about the composition, dynamics, and function of human microglial phagosomes under homeostatic and pathological conditions. Wogram et al. develop a method to isolate human microglial phagosomes for unbiased metabolomic and proteomic pro…
The intestinal microbiota influences cancer immunosurveillance in extraintestinal tumors via three potential mechanisms: (1) the gut-to-tumor translocation of microbes, (2) the migration of intestinal leukocytes toward the tumor microenvironment, and (…
Neutrophils, crucial in host defense, traverse endothelial layers to infiltrate tissues and eliminate invasive pathogens. Throughout this journey, they surmount a variety of mechanical forces, such as sheer stresses from blood flow, as well as compress…
