Sympathetic over-excitation could take place as a secondary factor contributing to hypertension. However, the mechanisms underlying sympathetic flare-up during hypertension are unclear. Wei et al. find that due to a distinct vasculature organization in…
Bioenergetic insufficiency contributes to acquired CD8+ T cell hypofunction in tumors. The signals that drive CD 8+ TIL metabolic failure are largely unknown. Jackson et al. show that the cytokine Meteorin-like (METRNL) causes TIL hypofunction by promo…
The transcription factor Foxp3, which is indispensable for Treg function, forms large protein complexes with co-factors, but how their interactions affect Treg function remains obscure. Ichiyama et al. reveal that Foxp3 associates with the transcriptio…
The discovery of naive CD4+ T cell transcriptional heterogeneity raises the question regarding its plasticity and the mechanisms that may perturb the basal state. Even et al. report that, in mice, helminth infection, but not commensal colonization, tra…
Non-classical monocytes (NCMs) are circulating phagocytes that patrol the vascular tree. Thierry et al. find that peripheral, rather than bone marrow, endothelial cells serve as the nurturing niche of NCMs. Adhesion of NCMs to endothelial cells facilit…
Interleukin (IL)-33 release is associated with cell death in the tumor microenvironment, and it has varied effects on tumor development and progression. In a model of squamous cell carcinoma, Erickson et al. show that cancer stem cells produce large on…
Whether stroke induces sustained pro-inflammatory and proatherogenic endothelial alterations in systemic vessels remains poorly understood. Liu et al. find that brain ischemia induces the persistent activation of endothelial Notch1 signaling in the per…
The mechanisms responsible for the age-related decline in remyelination are incompletely understood. Tiwari et al. demonstrate that epigenetic reprogramming via innate immune training with BCG vaccination or conditional deletion of HDAC1/2 in microglia…
The general guidelines directing immune cell residency within tissues are poorly understood. Here, Simon et al. define the epigenetic landscapes and transposable element accessibility of CD45+ immune cells from murine and human tissues. This resource p…
Epigenomic features steering CD8+ T cell heterogeneity across tissues has not yet been extensively explored. By profiling chromatin accessibility changes and gene expression in T cells derived from multiple organs, Buquicchio et al. reveal the epigenet…
