Due to technical constraints, how memory T cells surveil the lung is not understood. Using intravital microscopy, van de Wall et al. demonstrate the unique surveillance properties of CD103+ TRM cells in the lungs of influenza-experienced mice. Upon ant…
Lassa fever causes thousands of deaths annually and lacks effective vaccines or therapies. Carr et al. use a non-replicative pseudovirus deep mutational scanning platform to determine how Lassa virus surface protein mutations affect cell entry and anti…
Antibiotics in early life increase the risk of subsequently developing asthma. Perdijk et al. show that depletion of the microbiome reduces systemic levels of the metabolite indole-3-propionic acid. This results in long-lasting mitochondrial damage wit…
Mast cell maturation dictates their secreted factors and functions. This process, however, remains unresolved. Taketomi et al. present lipid mediators as a central hub of mast cell maturation. They further detail a highly coordinated mast cell-fibrobla…
We suggest that the U, L, W, and J age-dependent patterns of death from infection result from the interplay between (1) genotypes affecting immunity to primary infection, related genotypes, or their phenocopies later in life and (2) the occurrence and …
The association of tertiary lymphoid structures (TLSs) with survival and immunotherapy response brought B cells to center stage. In a pan-cancer B cells atlas in Science, Ma et al. show that germinal center reaction generating anti-tumor antibody-secre…
Skin inflammation is potentiated by coordinated epithelial and immune cell metabolism. In this issue of Immunity, Subudhi and Konieczny et al. delineate how HIF1α regulates epithelial cell glycolysis during psoriasis. In turn, lactate is a byproduct th…
Autoreactive lymphocytes that infiltrate the pancreatic islet environment and target β cells are primary drivers of type 1 diabetes. In this issue of Immunity, Srivastava et al. examine the role of the islet microenvironment in autoimmunity and find th…
Antibodies modulate ongoing and future B cell responses. Cyster and Wilson review the various mechanisms whereby antibody feedback shapes B cell responses and present a framework for conceptualizing the ways antigen-specific antibody may influence immu…
(Immunity 57, 1225–1242.e1–e6; June 11, 2024)
