Journal of Leukocyte Biology

Intrinsic differences in hamster and mouse macrophage biology correlate with susceptibility to Leishmania donovani infection​Paul Jenkins on 4 de April de 2026 at 10:00

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J Leukoc Biol. 2026 Apr 2;118(4):qiag027. doi: 10.1093/jleuko/qiag027. ABSTRACT The basis for differential susceptibility to Leishmania donovani infection observed in individuals remains poorly understood. Here we address this important open question comparing bone marrow-derived macrophages (BMDMs) from susceptible hamsters (hamBMDMs) and resistant mice (mBMDMs) to identify intrinsic cellular features that may contribute to host-specific outcomes. … Read more

Re-defining granulomas: bacterial effectors, host circuits, and spatially resolved immunity​Daniel S C Butler on 1 de April de 2026 at 10:00

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J Leukoc Biol. 2026 Apr 1:qiag045. doi: 10.1093/jleuko/qiag045. Online ahead of print. ABSTRACT Granulomas are organized immune aggregates of myeloid and lymphoid cells that arise when the host fails to eliminate persistent stimuli; however, their function remains paradoxical, by promoting both protection from systemic dissemination while also promoting a niche for microbial survival. Traditionally defined … Read more

WGCNA and machine learning identify mitochondria programmed cell death-related genes as diagnostic biomarkers for septic shock​Di Yu on 28 de March de 2026 at 10:00

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J Leukoc Biol. 2026 Mar 28:qiag044. doi: 10.1093/jleuko/qiag044. Online ahead of print. ABSTRACT Septic shock (SS), the most severe stage of sepsis, has a high mortality rate. Mitochondria-mediated programmed cell death (MPCD) plays a key role in SS pathogenesis, but its diagnostic value remains unclear. This study integrated the GEO public dataset and used the … Read more

Neutrophil Biology and Fate Reprogramming in Bacterial Infections: Mechanisms, Plasticity, and Therapeutic Targeting​Asmaa H Mahmoud on 27 de March de 2026 at 10:00

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J Leukoc Biol. 2026 Mar 27:qiag033. doi: 10.1093/jleuko/qiag033. Online ahead of print. ABSTRACT Neutrophils are essential leukocytes in bacterial infections, with their fate and immune regulation critically shaping disease outcomes. They eliminate pathogens through phagocytosis, degranulation, oxidative burst-mediated killing, and the release of neutrophil extracellular traps (NETs), yet these defenses can also trigger excessive inflammation … Read more

Uncovering the Gut-Immune-Joint Axis: Causal Links Between Gut Microbiota, Immune Cells, and Osteoarthritis​Yuxi Liu on 25 de March de 2026 at 10:00

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J Leukoc Biol. 2026 Mar 25:qiag042. doi: 10.1093/jleuko/qiag042. Online ahead of print. ABSTRACT Gut microbiota have been increasingly implicated in osteoarthritis (OA), but causal pathways remain unclear. Using the Gut-Immune-Joint Axis framework, we analyzed publicly available genome-wide association study (GWAS) summary statistics from one primary and two secondary datasets to evaluate genetically predicted associations between … Read more

Human macrophage phagocytosis of lung cancer cells induced by CD47 blockade is augmented after knockdown of phagocytosis checkpoints mediated by siRNA-loaded lipid nanoparticles​Kristian W Antonsen on 25 de March de 2026 at 10:00

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J Leukoc Biol. 2026 Mar 25:qiag043. doi: 10.1093/jleuko/qiag043. Online ahead of print. ABSTRACT Macrophages can phagocytose tumor cells. However, tumor cells may avoid phagocytosis by activating macrophage-expressed phagocytosis checkpoints such as SIRPα, LILRB1, or Siglec-10. Here, we investigated if LNPs loaded with siRNA (siRNA-LNPs) specifically neutralizing these checkpoints may be used as a counter-regulatory approach … Read more

Eosinophil Adaptation in the Intestine: Microenvironmental Cues and Regulatory Roles​Yuande Wang on 22 de March de 2026 at 10:00

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J Leukoc Biol. 2026 Mar 23:qiag039. doi: 10.1093/jleuko/qiag039. Online ahead of print. ABSTRACT Eosinophils are granulocytes that undergo extensive transcriptional and functional remodeling as they adapt to tissue-specific microenvironments, enabling them to perform context-dependent roles in both homeostasis and disease. The intestine, one of the most eosinophil-rich organs, exhibits profound spatial, temporal, and physiological heterogeneity … Read more

Lymphocyte subsets: New hope for noninvasive biomarkers of prostate cancer​Chunjin Ke on 20 de March de 2026 at 10:00

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J Leukoc Biol. 2026 Mar 20:qiag041. doi: 10.1093/jleuko/qiag041. Online ahead of print. ABSTRACT Tumorigenesis and progression are driven by immune dysregulation and escape, thus evaluating immune function is crucial for the identification of diseases or health conditions. Currently, there is a lack of non-invasive biomarkers in the overall management of PCa to assess a patient’s … Read more

The Role of Duffy Antigen Receptor for Chemokines in Acute Respiratory Distress Syndrome​Catherine N Moscinski on 17 de March de 2026 at 10:00

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J Leukoc Biol. 2026 Mar 17:qiag036. doi: 10.1093/jleuko/qiag036. Online ahead of print. ABSTRACT Dysregulated inflammation in response to inciting events leads to severe end-organ dysfunction and failure, contributing to long-term morbidity and ultimately potentially death. Duffy Associated Receptor for Chemokines (DARC), a major regulator of inflammation, play key roles in a variety of acute and … Read more

A Biotin Ligation Assay Reveals a Complex Proxiome for HLA-A2 and Implicates MIA3 in Cell Surface Expression of MHC Class i Molecules​William Mitchell on 16 de March de 2026 at 10:00

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J Leukoc Biol. 2026 Mar 16:qiag035. doi: 10.1093/jleuko/qiag035. Online ahead of print. ABSTRACT Antigen presentation via MHC class I molecules (MHC-Is) is a turning point in the establishment of immune responses to endogenous threats, such as viruses. From their synthesis to their cell surface display, MHC-Is travel to many compartments, including the ER, Golgi, and … Read more

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