Journal of Leukocyte Biology

J Leukoc Biol. 2026 Aug 7:qiag111. doi: 10.1093/jleuko/qiag111. Online ahead of print. ABSTRACT Obesity is a disease associated with an increased risk of various medical complications, including cardiovascular problems, diabetes, and infectious diseases. The higher incidence of infections in individuals with obesity is likely due to impaired immune functions. Neutrophils deploy microbicidal functions. However, it … Read more

J Leukoc Biol. 2026 Aug 7:qiag112. doi: 10.1093/jleuko/qiag112. Online ahead of print. ABSTRACT Neutrophils are required for production of protective antibodies in response to the pneumococcal conjugate vaccine (PCV), however, the mechanisms behind that are not known. Here, using a mouse model, we found that depletion of neutrophils at the time of vaccination in female … Read more

J Leukoc Biol. 2026 Aug 6:qiag109. doi: 10.1093/jleuko/qiag109. Online ahead of print. ABSTRACT The complement system constitutes a fundamental element of the innate immune response, playing a pivotal role in the identification and eradication of pathogens. The orchestration of complement component activation is closely linked to bone remodeling and the maintenance of skeletal homeostasis. C3a … Read more

J Leukoc Biol. 2026 Aug 4:qiag108. doi: 10.1093/jleuko/qiag108. Online ahead of print. ABSTRACT Critical care research focuses on life-threatening conditions such as sepsis, trauma, hemorrhage, and burn injury, which account for millions of hospitalizations and hundreds of thousands of deaths annually in the United States alone. Recent policy initiatives by the U.S. Food and Drug … Read more

J Leukoc Biol. 2026 Aug 3:qiag106. doi: 10.1093/jleuko/qiag106. Online ahead of print. ABSTRACT Emerging evidence has highlighted the influence of cellular metabolism on both cancer and T cell growth and survival, including in the context of adoptive cell immunotherapy. It is known that T cells heavily rely on glycolysis for cell proliferation and mediating effector … Read more

J Leukoc Biol. 2026 Aug 3:qiag107. doi: 10.1093/jleuko/qiag107. Online ahead of print. ABSTRACT The SARS-CoV-2 virus significantly evolved with several new strains identified. Transmissibility has increased with each strain, corresponding with a decrease in mortality. We previously demonstrated novel dysfunctional neutrophil responses in alpha COVID-19 patients compared to community acquired pneumonia controls. We investigated if … Read more

J Leukoc Biol. 2026 Jul 31:qiag105. doi: 10.1093/jleuko/qiag105. Online ahead of print. ABSTRACT Premature birth and cesarean section are associated with increased morbidity and inflammatory diseases. However, their impact on neonatal immunity remains incompletely defined. To explore how gestational age and mode of delivery contribute to early immune programming, we analyzed CD4+ T cells, central … Read more

J Leukoc Biol. 2026 Jul 31;118(8):qiag104. doi: 10.1093/jleuko/qiag104. NO ABSTRACT PMID:42536813 | DOI:10.1093/jleuko/qiag104

J Leukoc Biol. 2026 Jul 3;118(7):qiag101. doi: 10.1093/jleuko/qiag101. NO ABSTRACT PMID:42520763 | DOI:10.1093/jleuko/qiag101

J Leukoc Biol. 2026 Jul 23:qiag092. doi: 10.1093/jleuko/qiag092. Online ahead of print. ABSTRACT Natural killer (NK) cells are central to cancer immunosurveillance and immunotherapy. Their ability to engage in killing is critical for efficient target elimination and depends on tightly regulated Ca2+ signaling controlling granzyme degranulation. TLR engagement has been linked to Ca2+ signaling in … Read more