Journal of Leukocyte Biology

J Leukoc Biol. 2026 Feb 27:qiag028. doi: 10.1093/jleuko/qiag028. Online ahead of print. ABSTRACT NF-κB inducing kinase (NIK), an upstream regulator of the noncanonical NF-κB signaling pathway, is implicated in the development of Hypereosinophilic-like syndrome (HES) in mice. HES in human patients is defined by 1.5×109 cells/L circulating in the blood with end-organ infiltration and resultant … Read more

J Leukoc Biol. 2026 Feb 26:qiag026. doi: 10.1093/jleuko/qiag026. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) are a critical component of the immune response to cancer, and their role in modulating cancer progression is well-recognized. Macrophages express pattern-recognition receptors, including Class A Scavenger Receptors (SR-A), which are pivotal in regulating macrophage activation and polarization into … Read more

J Leukoc Biol. 2026 Feb 25:qiag023. doi: 10.1093/jleuko/qiag023. Online ahead of print. ABSTRACT Allergic rhinitis (AR) is a prevalent inflammatory disorder with limited therapeutic options. Ephedra sinica Stapf (ESP), a traditional Chinese herb, has shown potential in respiratory diseases, but its bioactive components and mechanisms remain unclear. This study investigates the anti-inflammatory effects of ESP-B4, … Read more

J Leukoc Biol. 2026 Feb 20:qiag024. doi: 10.1093/jleuko/qiag024. Online ahead of print. ABSTRACT Dendritic cells (DCs) function within tissues that experience wide fluctuations in oxygen availability, and these hypoxic environments exert a strong influence on innate immune activity. In this context, we identify the Hippo pathway effector YAP1 as a central regulator of human monocyte-derived … Read more

J Leukoc Biol. 2026 Feb 9;118(2):qiaf174. doi: 10.1093/jleuko/qiaf174. ABSTRACT Neutrophils are the first responders of our innate immune system, crucial for defense against various infections. The intricate regulation of neutrophil migration is essential for neutrophil function. However, a complete mechanistic understanding is missing. We previously performed a miRNA overexpression screen and identified miR-190 as a … Read more

J Leukoc Biol. 2026 Feb 9;118(2):qiag008. doi: 10.1093/jleuko/qiag008. ABSTRACT Neutrophils are key first responders to both infectious and noninfectious stress, playing a pivotal role in maintaining homeostasis through tightly regulated activation states and the release of inflammatory mediators. The Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a key regulator of inflammation and … Read more

J Leukoc Biol. 2026 Feb 9;118(2):qiag013. doi: 10.1093/jleuko/qiag013. NO ABSTRACT PMID:41662165 | DOI:10.1093/jleuko/qiag013

J Leukoc Biol. 2026 Feb 4:qiag019. doi: 10.1093/jleuko/qiag019. Online ahead of print. ABSTRACT Natural killer (NK) cell antibody-dependent cellular cytotoxicity (ADCC) contributes to effective antiviral immunity, yet the relative contribution of NK cell-intrinsic factors and antibodies in mediating these responses remain poorly understood. Here, we combined functional ADCC assays with single-cell transcriptomics of peripheral NK … Read more

J Leukoc Biol. 2026 Feb 3:qiag020. doi: 10.1093/jleuko/qiag020. Online ahead of print. ABSTRACT Despite advances in engineered adaptive immune cell therapies, current options for innate immune cell therapies are sparse. In this work, we demonstrate the utility of a neutrophil progenitor-based cell therapy. Murine conditionally-immortalized neutrophil progenitors (NPs) overcome some of the hurdles of alternative … Read more

J Leukoc Biol. 2026 Jan 31:qiag016. doi: 10.1093/jleuko/qiag016. Online ahead of print. ABSTRACT Acute myeloid leukemia (AML) is characterized by profound immune dysregulation, yet the mechanisms underlying impaired cytotoxicity remain unclear. By analyzing samples from 20 AML patients and 20 healthy donors, we integrated scRNA-seq (GSE223844), bulk transcriptomes (GSE37642, GSE71014), and TCGA-AML. Single-cell profiling, BayesPrism … Read more