Journal of Leukocyte Biology

J Leukoc Biol. 2025 Dec 30:qiaf187. doi: 10.1093/jleuko/qiaf187. Online ahead of print. ABSTRACT Cholesterol metabolism plays a pivotal role in gastrointestinal (GI) cancers, from fuelling tumor growth, facilitating metastatic niche formation, shaping tumor immunosuppressive microenvironment to promoting immunotherapy resistance. Paradoxically, cholesterol may also exert context-dependent protective effects. Statins, the most widely prescribed cholesterol-lowering drugs, function … Read more

J Leukoc Biol. 2025 Dec 24:qiaf182. doi: 10.1093/jleuko/qiaf182. Online ahead of print. ABSTRACT Neutrophil extracellular traps (NETs) have been increasingly recognized as important modulators of tumor immunity. In this study, we investigated the prognostic significance of NETs-related genes expression and their impact on tertiary lymphoid structures (TLSs) in lung adenocarcinoma (LUAD). Using transcriptomic data from … Read more

J Leukoc Biol. 2025 Dec 24:qiaf184. doi: 10.1093/jleuko/qiaf184. Online ahead of print. ABSTRACT Relapse and therapy resistance remain major barriers to improving clinical outcomes in acute myeloid leukemia (AML), underscoring the need for actionable therapeutic targets. In this study, we identify calcium/calmodulin-dependent protein kinase II delta (CaMKIIδ) as a novel vulnerability in AML. CaMKIIδ is … Read more

J Leukoc Biol. 2025 Dec 22:qiaf183. doi: 10.1093/jleuko/qiaf183. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a systemic autoimmune disease. The underlying disease mechanisms remain poorly understood and there are no curative therapies. MyD88-mediated signaling is essential for SjD, although the pathways that rely on MyD88 are not well characterized. Our objective was to … Read more

J Leukoc Biol. 2025 Dec 19:qiaf180. doi: 10.1093/jleuko/qiaf180. Online ahead of print. ABSTRACT Precursor exhausted and terminally exhausted T cells (Tpex and Tex) are associated with immune checkpoints, T-cell checkpoint blockade may improve patient survival. We assessed cytotoxic activity and PD-1/TIM-3 expressions of CD3+CD8+CD56+ T cells (NK-like T) in cytokine-induced killer (CIK) cells across exhaustion … Read more

J Leukoc Biol. 2025 Dec 15:qiaf181. doi: 10.1093/jleuko/qiaf181. Online ahead of print. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy by enhancing anti-tumor immunity, but their use is frequently complicated by immune-related adverse events (irAEs), particularly ICI-induced diarrhea and colitis. Growing evidence suggests that RNA-binding proteins (RBPs), which are critical post-transcriptional regulators of immune … Read more

J Leukoc Biol. 2025 Dec 12:qiaf179. doi: 10.1093/jleuko/qiaf179. Online ahead of print. ABSTRACT While sex differences in neutrophil metabolism have been documented, whether this metabolic dimorphism extends to specific neutrophil subsets remains unknown.LDNs are characterized by their lower buoyant density compared to normal-density neutrophils(NDNs), are present in low numbers in healthy individuals, and are often … Read more

J Leukoc Biol. 2025 Dec 12:qiaf178. doi: 10.1093/jleuko/qiaf178. Online ahead of print. ABSTRACT Arthritis imposes a substantial global burden and remains without curative therapy. Among the most prevalent forms, rheumatoid arthritis (RA) and osteoarthritis (OA) differ in etiology but converge on pathogenic tumor necrosis factor-α (TNFα) signaling. A key regulatory node is TNFR2, which promotes … Read more

J Leukoc Biol. 2025 Dec 11:qiaf175. doi: 10.1093/jleuko/qiaf175. Online ahead of print. ABSTRACT Pediatric burn injury induces concurrent systemic inflammation and immune dysfunction, which is associated with adverse clinical outcomes (e.g., infections). For that reason, immunomodulating therapies, such as granulocyte macrophage colony-stimulating factor (GM-CSF), have been of great interest to augment the immune response following … Read more

J Leukoc Biol. 2025 Dec 8:qiaf172. doi: 10.1093/jleuko/qiaf172. Online ahead of print. ABSTRACT Ovarian cancer remains the most lethal gynecologic malignancy, due in part to the establishment of a profoundly immunosuppressive tumor microenvironment (TME). While toll-like receptor 5 (TLR5) signaling has previously been implicated in promoting myeloid cell recruitment to the ovarian TME, source(s) of … Read more