Journal of Leukocyte Biology

Non-canonical NF-κB signaling in dendritic cells is required for ATP-driven indoleamine 2,3-dioxygenase 1 induction through P2Y11 receptor​Darina Ocadlikova on 3 de February de 2025 at 11:00

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J Leukoc Biol. 2025 Feb 3:qiaf010. doi: 10.1093/jleuko/qiaf010. Online ahead of print. ABSTRACT Extracellular ATP released from dying cells, including tumor cells, is a key mediator of inflammation and tolerance by binding to purinergic receptors on dendritic cells, resulting in inflammasome activation (via P2X7R), dendritic cell maturation (via P2Y11R), and Indoleamine-2,3-dioxygenase 1 upregulation. However, the … Read more

Nexinhib20 inhibits JFC1-mediated mobilization of a subset of CD11b/CD18+ vesicles decreasing integrin avidity, but does not inhibit Rac1​Kasra Askari on 30 de January de 2025 at 11:00

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J Leukoc Biol. 2025 Jan 30:qiaf012. doi: 10.1093/jleuko/qiaf012. Online ahead of print. ABSTRACT Regulated sequential exocytosis of neutrophil granules is essential in orchestrating the innate immune response, while uncontrolled secretion causes inflammation. We developed and characterized Nexinhib20, a small-molecule inhibitor that targets azurophilic granule exocytosis in neutrophils by blocking the interaction between the small GTPase … Read more

Flow cytometric measurement of CFTR-mediated chloride transport in human neutrophils​Alejandra Montanez-Barragan on 21 de January de 2025 at 11:00

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J Leukoc Biol. 2025 Jan 22:qiaf006. doi: 10.1093/jleuko/qiaf006. Online ahead of print. ABSTRACT Immune cells express a variety of ion channels and transporters in the plasma membrane and intracellular organelles, responsible of the transference of charged ions across hydrophobic lipid membrane barriers. The correct regulation of ion transport ensures proper immune cell function, activation, proliferation, … Read more

Single-cell RNA Sequencing Revealed the Immunophenotypic Features of Macrophages in Cardiac Transplants and Uncovered Lgals9 Promoted Their Polarization towards The M2b Subtype​Yuexing Zhu on 21 de January de 2025 at 11:00

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J Leukoc Biol. 2025 Jan 21:qiaf009. doi: 10.1093/jleuko/qiaf009. Online ahead of print. ABSTRACT Macrophages play a crucial role in the immune response during allograft rejection in organ transplantation. Therefore, our study aimed to explore the genomic features of macrophages in mouse heart transplants and use single-cell RNA sequencing to investigate Galectin-9 (Gal-9, Lgals9), a lectin … Read more

Relevance of mouse and human IBD patients-derived colon organoids to investigate intestinal macrophage differentiation​Maxime Costa on 20 de January de 2025 at 11:00

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J Leukoc Biol. 2025 Jan 21:qiaf004. doi: 10.1093/jleuko/qiaf004. Online ahead of print. ABSTRACT The gastrointestinal tract is a remarkable example of complex biology, with a constant dialogue between the intestinal epithelium, in close contact with the microbiota, and the immune cells that protect the gut from infection. Organoids have revolutionized our approach to modelling the … Read more

Gut-resident Tregs (GTregs) play a pivotal role in maintaining bone health under post-menopausal osteoporotic conditions​Asha Bhardwaj on 20 de January de 2025 at 11:00

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J Leukoc Biol. 2025 Jan 20:qiaf008. doi: 10.1093/jleuko/qiaf008. Online ahead of print. ABSTRACT Osteoporosis is a skeletal condition characterized by the deterioration of bone tissue. The immune system plays a crucial role in maintaining bone homeostasis and combating the development of osteoporosis. Immunoporosis is the term used to describe the recent convergence of research on … Read more

Adenosine accumulation in the blood of newborn mice weakens antimicrobial host defenses​Carola Ledderose on 17 de January de 2025 at 11:00

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J Leukoc Biol. 2025 Jan 18:qiaf003. doi: 10.1093/jleuko/qiaf003. Online ahead of print. ABSTRACT Pediatric intensive care patients are particularly susceptible to severe bacterial infections because of ineffective neutrophil responses. The reasons why neutrophils of newborns are less responsive than those of adults are not clear. Because adenosine triphosphate (ATP) and adenosine (ADO) tightly regulate neutrophils, … Read more

Protocols for circulating neutrophil depletion in neonatal C57Bl/6 mice​Devashis Mukherjee on 17 de January de 2025 at 11:00

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J Leukoc Biol. 2025 Jan 17:qiaf005. doi: 10.1093/jleuko/qiaf005. Online ahead of print. ABSTRACT Murine neonatal neutrophil depletion strategies have problems achieving deep neutrophil clearance and accurate residual neutrophil fraction detection. An isotype switch method can achieve profound neutrophil clearance using a combination of anti-Ly6G and anti-rat κ Ig light chain antibodies in adult C57Bl/6 mice, … Read more

Thymic Eosinophils: What Are You Doing Here?​Dominique M Gatti on 8 de January de 2025 at 11:00

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J Leukoc Biol. 2025 Jan 8:qiaf001. doi: 10.1093/jleuko/qiaf001. Online ahead of print. ABSTRACT The thymus is a primary lymphoid organ where major types of T lymphocytes undergo essential developmental processes. Eosinophils are among the cell types present in microenvironments within the thymus, and perhaps surprisingly, the role of thymic eosinophils, especially during homeostatic conditions, remains … Read more

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