Journal of Leukocyte Biology

J Leukoc Biol. 2025 Nov 17:qiaf165. doi: 10.1093/jleuko/qiaf165. Online ahead of print. ABSTRACT Patients who survive sepsis experience a prolonged period of immunosuppression. This period is accompanied by the expansion of monocytic myeloid-derived suppressor cells (M-MDSCs), a subset of suppressive myeloid cells; however, the impact of M-MDSCs on the innate immune response to infection is … Read more

J Leukoc Biol. 2025 Nov 17:qiaf166. doi: 10.1093/jleuko/qiaf166. Online ahead of print. ABSTRACT Gamma-aminobutyric acid (GABA), a non-protein component amino acid, functions as an inhibitory neurotransmitter. Here, we showed that GABA levels are significantly elevated in the bone marrow (BM) liquid of patients with multiple myeloma (MM) compared to healthy donors (HDs). Moreover, BM GABA … Read more

J Leukoc Biol. 2025 Nov 14:qiaf164. doi: 10.1093/jleuko/qiaf164. Online ahead of print. ABSTRACT Following the 2025 Nobel Prize in Physiology or Medicine for the discovery of regulatory T cells (Tregs), a recent article in Nature Communications reports the creation of allogeneic, genome-edited Tregs engineered to evade immune rejection while retaining suppressive function. Through non-viral CRISPR … Read more

J Leukoc Biol. 2025 Nov 13:qiaf163. doi: 10.1093/jleuko/qiaf163. Online ahead of print. ABSTRACT Mycoplasma pneumoniae (Mp) is a frequent cause of pediatric pneumonia, largely due to the challenges in early detection and the tendency to underestimate the severity of infections. Emerging evidence suggests that ATP-binding cassette transporter G1 (ABCG1) plays a critical role in preventing … Read more

J Leukoc Biol. 2025 Nov 10:qiaf161. doi: 10.1093/jleuko/qiaf161. Online ahead of print. ABSTRACT Neutrophils, our frontline of defense against pathogens, exhibit pronounced sexual dimorphism in ontogeny, phenotype, and effector functions. Throughout the human lifespan, estrogen and androgen signaling, together with sex-linked genetic regulators, orchestrate neutrophil production, maturation, and immune activity, contributing to immunological differences between … Read more

J Leukoc Biol. 2025 Nov 10:qiaf155. doi: 10.1093/jleuko/qiaf155. Online ahead of print. ABSTRACT Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, affects millions worldwide, with a high prevalence in Latin America, representing a significant public health burden. The transition from the asymptomatic acute phase to the chronic stage, where about 30% of individuals develop … Read more

J Leukoc Biol. 2025 Nov 8:qiaf158. doi: 10.1093/jleuko/qiaf158. Online ahead of print. ABSTRACT Eosinophils play an important role in mediating itch and inflammation in dermatitis. The role of the eosinophil granule protein eosinophil peroxidase (EPX) in mediating inflammation and itch was tested in a dermatitis mouse model. Mice were sensitized to trimellitic anhydride (TMA) and … Read more

J Leukoc Biol. 2025 Nov 7:qiaf160. doi: 10.1093/jleuko/qiaf160. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) play a crucial role in the immune system, and their dysfunction can lead to the development of autoimmune conditions. In cancer, tumors frequently hijack the immunosuppressive function of Tregs to evade immune responses. Due to their central role … Read more

J Leukoc Biol. 2025 Nov 7:qiaf159. doi: 10.1093/jleuko/qiaf159. Online ahead of print. ABSTRACT The Ets family transcription factor PU.1 plays multiple roles in hematopoiesis. PU.1 acts in a graded manner to regulate myeloid and lymphoid development with high expression levels promoting monopoiesis and low expression levels instructing B cell fate. It remains incompletely understood how … Read more

J Leukoc Biol. 2025 Nov 6:qiaf156. doi: 10.1093/jleuko/qiaf156. Online ahead of print. ABSTRACT Evolutionarily conserved HOXA9 is a well-known player of haematopoiesis and leukemogenesis. However, the involvement of this transcription factor in CD4+T cell development is largely unexplored. Th2 cells play a critical role in the pathogenesis of numerous autoimmune disorders. The development of this … Read more