Journal of Leukocyte Biology

Gamma-aminobutyric acid-B receptor axis promotes proliferation and survival of multiple myeloma cells via enhancing ERK1/2 activity​Wei Hu on 17 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 17:qiaf166. doi: 10.1093/jleuko/qiaf166. Online ahead of print. ABSTRACT Gamma-aminobutyric acid (GABA), a non-protein component amino acid, functions as an inhibitory neurotransmitter. Here, we showed that GABA levels are significantly elevated in the bone marrow (BM) liquid of patients with multiple myeloma (MM) compared to healthy donors (HDs). Moreover, BM GABA … Read more

Building Tolerance: Employing Genome Engineering Toward Universal Treg Therapy​Julian J Freen-van Heeren on 14 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 14:qiaf164. doi: 10.1093/jleuko/qiaf164. Online ahead of print. ABSTRACT Following the 2025 Nobel Prize in Physiology or Medicine for the discovery of regulatory T cells (Tregs), a recent article in Nature Communications reports the creation of allogeneic, genome-edited Tregs engineered to evade immune rejection while retaining suppressive function. Through non-viral CRISPR … Read more

Knocking down ABCG1 activates NLRP3/Caspase-1 pathway to promote neutrophil pyroptosis and exacerbate Mycoplasma pneumoniae pneumonia in children​Lisha Cai on 13 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 13:qiaf163. doi: 10.1093/jleuko/qiaf163. Online ahead of print. ABSTRACT Mycoplasma pneumoniae (Mp) is a frequent cause of pediatric pneumonia, largely due to the challenges in early detection and the tendency to underestimate the severity of infections. Emerging evidence suggests that ATP-binding cassette transporter G1 (ABCG1) plays a critical role in preventing … Read more

Sex differences in neutrophil biology​Mathis Richter on 10 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 10:qiaf161. doi: 10.1093/jleuko/qiaf161. Online ahead of print. ABSTRACT Neutrophils, our frontline of defense against pathogens, exhibit pronounced sexual dimorphism in ontogeny, phenotype, and effector functions. Throughout the human lifespan, estrogen and androgen signaling, together with sex-linked genetic regulators, orchestrate neutrophil production, maturation, and immune activity, contributing to immunological differences between … Read more

Trypanosoma cruzi trypomastigote infection drives TLR2-NF-κB-IL-1β axis activation associated with systolic dysfunction in chronic Chagas cardiomyopathy​Mariana Costa Duarte on 10 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 10:qiaf155. doi: 10.1093/jleuko/qiaf155. Online ahead of print. ABSTRACT Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, affects millions worldwide, with a high prevalence in Latin America, representing a significant public health burden. The transition from the asymptomatic acute phase to the chronic stage, where about 30% of individuals develop … Read more

Eosinophil peroxidase induces inflammation in a mouse model of dermatitis​James Kornfield on 9 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 8:qiaf158. doi: 10.1093/jleuko/qiaf158. Online ahead of print. ABSTRACT Eosinophils play an important role in mediating itch and inflammation in dermatitis. The role of the eosinophil granule protein eosinophil peroxidase (EPX) in mediating inflammation and itch was tested in a dermatitis mouse model. Mice were sensitized to trimellitic anhydride (TMA) and … Read more

Method for generation and ex vivo expansion of genetically edited mouse Tregs​Yosef Gilad on 9 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 7:qiaf160. doi: 10.1093/jleuko/qiaf160. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) play a crucial role in the immune system, and their dysfunction can lead to the development of autoimmune conditions. In cancer, tumors frequently hijack the immunosuppressive function of Tregs to evade immune responses. Due to their central role … Read more

A Critical Role of the Erk1/2 Downstream Targets c-Fos, Egr-1 and Egr-2 in PU.1-Driven Monocyte Development​Hafiza Sidra Bashir on 9 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 7:qiaf159. doi: 10.1093/jleuko/qiaf159. Online ahead of print. ABSTRACT The Ets family transcription factor PU.1 plays multiple roles in hematopoiesis. PU.1 acts in a graded manner to regulate myeloid and lymphoid development with high expression levels promoting monopoiesis and low expression levels instructing B cell fate. It remains incompletely understood how … Read more

HOXA9-PBX1 axis orchestrates divergent Th2 cytokine expression​Sayantee Hazra on 8 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 6:qiaf156. doi: 10.1093/jleuko/qiaf156. Online ahead of print. ABSTRACT Evolutionarily conserved HOXA9 is a well-known player of haematopoiesis and leukemogenesis. However, the involvement of this transcription factor in CD4+T cell development is largely unexplored. Th2 cells play a critical role in the pathogenesis of numerous autoimmune disorders. The development of this … Read more

Enhancing Tyro3 signalling ameliorates IL-1β production through STAT1 in Alzheimer’s disease models​Kishore Aravind Ravichandran on 8 de November de 2025 at 11:00

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J Leukoc Biol. 2025 Nov 5:qiaf157. doi: 10.1093/jleuko/qiaf157. Online ahead of print. ABSTRACT Neuroinflammation plays a vital role in determining the trajectory of Alzheimer’s disease (AD) progression. In AD brain, microglial exposure to pathological amyloid β (Aβ42) and tau peptide aggregates results in an NLRP3 inflammasome-activated pro-inflammatory response that ranges from mild to severe. Recently … Read more

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