Journal of Leukocyte Biology

J Leukoc Biol. 2025 Oct 10:qiaf139. doi: 10.1093/jleuko/qiaf139. Online ahead of print. ABSTRACT Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the uncontrolled proliferation of immature lymphoid cells, but the role of circNR3C1 in ALL is not fully elucidated. In this study, expression levels of circNR3C1, RPS3, ENO1, and MSI2 were assessed in … Read more

J Leukoc Biol. 2025 Oct 10:qiaf143. doi: 10.1093/jleuko/qiaf143. Online ahead of print. ABSTRACT Adoptive cell therapy using ex vivo expanded autologous Tregs could be a novel therapeutic approach for cell-based immunotherapy in dogs. This study aimed to expand dog Treg lymphocytes via the use of tregitopes. PBMCs were isolated from healthy beagle dogs and stimulated … Read more

J Leukoc Biol. 2025 Oct 9:qiaf142. doi: 10.1093/jleuko/qiaf142. Online ahead of print. ABSTRACT Neutrophils are central to immune responses in health and disease, and their ability to deform correlates with their functional responses. In health, reorganisation of the neutrophil cytoskeleton allows neutrophils to carry out their effector mechanisms. However, in the disease state, dysregulation of … Read more

J Leukoc Biol. 2025 Oct 7:qiaf141. doi: 10.1093/jleuko/qiaf141. Online ahead of print. ABSTRACT Regulatory B cells (Bregs), specifically the CD24⁺CD38⁺ phenotype, are known for their capacity to reduce inflammation by releasing interleukin 10(IL-10). However, their potential role in regulating inflammation through macrophage differentiation is not well understood. This study investigates how CD24⁺CD38⁺ regulatory B cells … Read more

J Leukoc Biol. 2025 Oct 7:qiaf140. doi: 10.1093/jleuko/qiaf140. Online ahead of print. ABSTRACT Toll-like receptor (TLR) signaling is vital for antimicrobial macrophage function, and its dysregulation is associated with diseases such as lupus, multiple sclerosis, pulmonary fibrosis, and cancer. The Src-family kinase Lyn may have net activating or inhibitory effects on TLR signaling, yet distinct … Read more

J Leukoc Biol. 2025 Oct 1;117(10):qiaf062. doi: 10.1093/jleuko/qiaf062. ABSTRACT The monocyte-to-macrophage transition is marked by alterations to both the structure and function of the genome, including changes in histone posttranslational modifications, DNA methylation, 3D nuclear architecture, and expression of lineage specific genes. The nucleosome is the fundamental organizational unit of the eukaryotic genome and underpins … Read more

J Leukoc Biol. 2025 Oct 1;117(10):qiaf067. doi: 10.1093/jleuko/qiaf067. ABSTRACT Macrophages detect lipopolysaccharide (LPS) through toll-like receptor 4 (TLR-4) on the cell surface which initiates a signaling cascade, resulting in the recruitment of regulatory factors to chromatin and subsequent expression of chemokine and cytokine genes. Primary response genes, marked by poised promoters and enhancers, are rapidly … Read more

J Leukoc Biol. 2025 Sep 30:qiaf137. doi: 10.1093/jleuko/qiaf137. Online ahead of print. ABSTRACT Neutrophils are key players in inflammatory responses that are modulated by cytokines/chemokines and damage associated molecular patterns (DAMPs). Exercise induces acute neutrophilia, but little is known regarding recruitment of neutrophil subsets (banded (CD16dim/CD62Lbright) and hypersegmented (CD16bright/CD62Ldim) cells) and it’s relation with the … Read more

J Leukoc Biol. 2025 Sep 26:qiaf134. doi: 10.1093/jleuko/qiaf134. Online ahead of print. ABSTRACT The immune response to Trypanosoma cruzi infection relies on robust inflammatory activation of macrophages and proper CD8+ T cells function to control parasite replication. However, an exacerbated respiratory burst from macrophages can damage tissues where parasites reside, such as the heart and … Read more

J Leukoc Biol. 2025 Sep 26:qiaf132. doi: 10.1093/jleuko/qiaf132. Online ahead of print. ABSTRACT Understanding the impact of Neutrophils and Macrophages in the dynamic outcome of resolution vs uncontrolled response is still an open debate. Here, we develop a mathematical model that describe the dynamic of the innate immune response after an acute damage. Our model … Read more