Journal of Leukocyte Biology

J Leukoc Biol. 2025 Nov 5:qiaf157. doi: 10.1093/jleuko/qiaf157. Online ahead of print. ABSTRACT Neuroinflammation plays a vital role in determining the trajectory of Alzheimer’s disease (AD) progression. In AD brain, microglial exposure to pathological amyloid β (Aβ42) and tau peptide aggregates results in an NLRP3 inflammasome-activated pro-inflammatory response that ranges from mild to severe. Recently … Read more

J Leukoc Biol. 2025 Nov 4:qiaf153. doi: 10.1093/jleuko/qiaf153. Online ahead of print. ABSTRACT Host defense functions of neutrophils during infection critically depend on microbicidal and proteolytic proteins stored in primary, secondary and tertiary granules that are released into the phagosome or into the extracellular space upon degranulation. Granules are generated during granulopoiesis and impaired granule … Read more

J Leukoc Biol. 2025 Oct 30:qiaf154. doi: 10.1093/jleuko/qiaf154. Online ahead of print. ABSTRACT α(1,3)-exofucosylation is an enzymatic process whereby the monosaccharide L-fucose is added in α(1,3)-linkage onto a pertinent acceptor glycan displayed by a cell membrane glycoprotein or glycolipid. One pertinent acceptor glycan is the terminal trisaccharide unit known as a “sialylated type 2 lactosamine”. … Read more

J Leukoc Biol. 2025 Oct 29:qiaf151. doi: 10.1093/jleuko/qiaf151. Online ahead of print. ABSTRACT The cytokine CSF-1 and its tyrosine kinase-encoding receptor CSF1R are important for the development and proliferation/survival of most tissue macrophages. We recently identified TNF-α-induced protein 2 (TNFAIP2) as a unique cellular regulator of CSF1R activation: TNFAIP2 increased the response of macrophages to … Read more

J Leukoc Biol. 2025 Oct 25:qiaf150. doi: 10.1093/jleuko/qiaf150. Online ahead of print. ABSTRACT Rhesus theta defensin (RTD)-1, a cyclic antimicrobial peptide, regulates gene expression and immune signaling pathways in cell culture and animal models of immune mediated diseases. In LPS stimulated cells, RTD-1 inhibition of pro-inflammatory cytokine secretion and gene expression is mediated through inhibition … Read more

J Leukoc Biol. 2025 Oct 22:qiaf146. doi: 10.1093/jleuko/qiaf146. Online ahead of print. ABSTRACT Mycobacterium tuberculosis, the causative agent of TB is responsible for extreme mortality and morbidity across the globe. The bacteria have evolved multiple strategies for their successful prevalence. The emergence of MDR-TB has established the importance of eliciting host-pathogen interactions at cellular and … Read more

J Leukoc Biol. 2025 Oct 22:qiaf148. doi: 10.1093/jleuko/qiaf148. Online ahead of print. ABSTRACT Neutrophils, the most abundant leukocytes in humans, exhibit significant differences from their murine counterparts, shaping immune responses and disease outcomes. Recent studies indicate that fungal exposure in rewilded mice modifies neutrophil development, aligning it more closely with human neutrophil characteristics and emphasizing … Read more

J Leukoc Biol. 2025 Oct 21:qiaf147. doi: 10.1093/jleuko/qiaf147. Online ahead of print. ABSTRACT Assembly of NADPH oxidase 2 (NOX2) proteins in neutrophils plays an essential role in controlling microbial infections by producing high levels of reactive oxygen species (ROS). We reported that neutrophils and NOX2 are required to control P. aeruginosa in a clinically relevant … Read more

J Leukoc Biol. 2025 Oct 17:qiaf145. doi: 10.1093/jleuko/qiaf145. Online ahead of print. ABSTRACT Myeloid cells- including monocytes, macrophages, dendritic cells (DCs), and granulocytes constitute a versatile arm of the immune system, serving as frontline sentinels that detect and react to environmental cues and orchestrate tailored immune responses. Their ability to respond promptly to distinct threats … Read more

J Leukoc Biol. 2025 Oct 14:qiaf144. doi: 10.1093/jleuko/qiaf144. Online ahead of print. ABSTRACT Metabolic remodeling is involved in multiple diseases, including tumors, acute and chronic inflammations, but our understanding of the molecular pathways remains limited. Neutrophils, as pivotal effector cells of the innate immune system, exhibit significant functional heterogeneity influenced by the hypoxic microenvironment, a … Read more