Journal of Leukocyte Biology

Transgenic αβ TCR tonic signaling is leukemogenic while strong stimulation is leukemia-suppressive​Telmo A Catarino on 22 de November de 2024 at 11:00

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J Leukoc Biol. 2024 Nov 22:qiae249. doi: 10.1093/jleuko/qiae249. Online ahead of print. ABSTRACT The pre-T cell receptor (TCR) and TCR complexes are frequently expressed in T-cell acute lymphoblastic leukemia (T-ALL), an aggressive T cell precursor malignancy. Although mutations in TCR components are infrequent in T-ALL, earlier research indicated that transgenic αβ TCR expression in mouse … Read more

The tumor-neutrophil interactions in the microenvironment of brain metastases with different primary sites​Tamer A Kaya on 20 de November de 2024 at 11:00

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J Leukoc Biol. 2024 Nov 20:qiae248. doi: 10.1093/jleuko/qiae248. Online ahead of print. ABSTRACT Brain metastases (BrM) originating from lung and breast cancer can recruit and activate neutrophils to acquire a tumor-promoting phenotype. It is currently unclear if this phenomenon also occurs in BrM arising from other primary sites. Here, we investigated the effect of tumor … Read more

Cannabinoid Receptor type 2 agonist GP1a attenuates macrophage activation induced by M. bovis-BCG by inhibiting NF-ĸB signaling​Jessica Do Prado Valeriano on 14 de November de 2024 at 11:00

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J Leukoc Biol. 2024 Nov 14:qiae246. doi: 10.1093/jleuko/qiae246. Online ahead of print. ABSTRACT Tuberculosis (TB) is one of the leading causes of death worldwide and a major public health problem. Immune evasion mechanisms and antibiotic resistance highlight the need to better understand this disease and explore alternative treatment approaches. Mycobacterial infection modulates the macrophage response … Read more

Neutrophil swarming is crucial for limiting oral mucosal infection by Candida albicans​Darpan Saraswat on 12 de November de 2024 at 11:00

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J Leukoc Biol. 2024 Nov 12:qiae239. doi: 10.1093/jleuko/qiae239. Online ahead of print. ABSTRACT Oral mucosal colonization by C. albicans (Ca) is benign in healthy people but progresses to deeper infection known as oropharyngeal candidiasis (OPC) that may become disseminated when combined with immunosuppression. Cortisone use and neutropenia are risk factors for invasive mucosal fungal infections, … Read more

New insights on extramedullary granulopoiesis and neutrophil heterogeneity in the spleen and its importance in disease​Rongxia Guo on 8 de November de 2024 at 11:00

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J Leukoc Biol. 2024 Nov 8:qiae220. doi: 10.1093/jleuko/qiae220. Online ahead of print. ABSTRACT Neutrophils are traditionally viewed as uncomplicated exterminators that arrive quickly at sites of infection, kill pathogens, and then expire. However, recent studies employing modern transcriptomics coupled with novel imaging modalities have discovered that neutrophils exhibit significant heterogeneity within organs and have complex … Read more

Macrophage foam cell-derived mediator promotes spontaneous fat lipolysis in atherosclerosis models​Dipanjan Banerjee on 7 de November de 2024 at 11:00

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J Leukoc Biol. 2024 Nov 7:qiae210. doi: 10.1093/jleuko/qiae210. Online ahead of print. ABSTRACT Ectopic lipid accumulation in macrophages is responsible for the formation of macrophage foam cells (MFCs) which are involved in the crosstalk with the perivascular adipose tissue (PVAT) of the vascular wall that plays a pivotal role in the progression of atherosclerosis. However, … Read more

Interleukin-10 inhibits important components of trained immunity in human monocytes​Rutger J Röring on 12 de November de 2024 at 11:00

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J Leukoc Biol. 2024 Nov 12:qiae240. doi: 10.1093/jleuko/qiae240. Online ahead of print. ABSTRACT Trained immunity induces antigen-agnostic enhancement of host defense and protection against secondary infections, but inappropriate activation can contribute to the pathophysiology of inflammatory diseases. Tight regulation of trained immunity is therefore needed to avoid pathology, but little is known about the endogenous … Read more

Role of the basic leucine zipper transcription factor BATF2 in modulating immune responses and inflammation in health and disease​Rick van der Geest on 6 de November de 2024 at 11:00

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J Leukoc Biol. 2024 Nov 6:qiae245. doi: 10.1093/jleuko/qiae245. Online ahead of print. ABSTRACT Basic leucine zipper transcription factor ATF-like 2 (BATF2) is a transcription factor that is known to exhibit tumor-suppressive activity in cancer cells. Within recent years, however, BATF2 has also emerged as an important transcriptional regulator of the immune system. Through its immunomodulatory … Read more

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