Journal of Leukocyte Biology – Page 17

Single-cell transcriptome analysis reveals atypical monocytes circulating ahead of acute graft-versus-host disease clinical onsetFilipe Martins on 21 de October de 2024 at 10:00

22 de October de 2024 by

J Leukoc Biol. 2024 Oct 21:qiae229. doi: 10.1093/jleuko/qiae229. Online ahead of print. ABSTRACT Acute graft-versus-host disease (aGVHD) represents the rejection of the recipient’s skin, gut, and liver tissues of an allogeneic hematopoietic stem cell transplantation (HSCT) by the donor T-cells. The onset of aGVHD is often rapid and its evolution is unpredictable. We undertook the … Read more

MerTK Signaling in Human Primary T cells Modulates Memory Potential and Improves Recall responseAnne Rahbech on 18 de October de 2024 at 10:00

19 de October de 2024 by

J Leukoc Biol. 2024 Oct 18:qiae226. doi: 10.1093/jleuko/qiae226. Online ahead of print. ABSTRACT Immune therapy using checkpoint inhibitors or adoptive cell transfer has revolutionized the treatment of several types of cancers. However, response to treatment is currently limited to a fraction of patients. Elucidation of immune modulatory mechanisms might optimize patient selection and present ways … Read more

The Peripheral Neuroimmune SystemKeaton Song on 18 de October de 2024 at 10:00

19 de October de 2024 by

J Leukoc Biol. 2024 Oct 18:qiae230. doi: 10.1093/jleuko/qiae230. Online ahead of print. ABSTRACT Historically, the nervous and immune systems were studied as separate entities. The nervous system relays signals between the body and the brain by processing sensory inputs and executing motor outputs, whereas the immune system provides protection against injury and infection through inflammation. … Read more

A new model measuring bacterial phagocytosis and phagolysosomal oxidisation in humans using the intradermal injection of methylene blue-labelled Escherichia coliGeorge B Collins on 16 de October de 2024 at 10:00

17 de October de 2024 by

J Leukoc Biol. 2024 Oct 16:qiae217. doi: 10.1093/jleuko/qiae217. Online ahead of print. ABSTRACT Phagocytosis is an important leucocyte function, however using existing models it cannot be measured in human tissues in vivo. To address this, we characterized a new phagocytosis model using intradermal methylene blue-labelled Escherichia coli injection (MBEC). Methylene blue (MB) is a licensed … Read more

Polarization of the memory B cell responseLizzette Pérez-Pérez on 14 de October de 2024 at 10:00

15 de October de 2024 by

J Leukoc Biol. 2024 Oct 14:qiae228. doi: 10.1093/jleuko/qiae228. Online ahead of print. ABSTRACT Memory B cells are long-lived cells that are induced following infection or vaccination. Upon antigen re-encounter, memory B cells rapidly differentiate into antibody-secreting or germinal center B cells. While memory B cells are an important component of long-term protective immunity following vaccination, … Read more

The Protective Role of Transcription Factor Nrf2 in Murine Macrophage Activation SyndromePaul M Gallo on 11 de October de 2024 at 10:00

11 de October de 2024 by

J Leukoc Biol. 2024 Oct 11:qiae225. doi: 10.1093/jleuko/qiae225. Online ahead of print. ABSTRACT OBJECTIVE: Macrophage activation syndrome (MAS) is characterized by multi-lineage cytopenias, hypercytokinemia, and tissue hemophagocytosis. Transcription factor Nrf2 is a master regulator of redox homeostasis. In this work we aim to investigate the role of Nrf2 in murine hyperinflammation and the mechanisms by … Read more

The Miniaturized Isolation of Neutrophil Granules (MING) method allowed a deep proteome mapping of human neutrophil granulesGabrielly Alexandria on 10 de October de 2024 at 10:00

10 de October de 2024 by

J Leukoc Biol. 2024 Oct 10:qiae224. doi: 10.1093/jleuko/qiae224. Online ahead of print. ABSTRACT Neutrophils are the innate immune system’s first line of defense, and their storage organelles are essential to their function. The storage organelles are divided into three different granule types named azurophilic, specific, and gelatinase granules, besides a fourth component called secretory vesicles. … Read more

Neutrophil plasticity in liver diseasesJia Ming Nickolas Teo on 9 de October de 2024 at 10:00

10 de October de 2024 by

J Leukoc Biol. 2024 Oct 9:qiae222. doi: 10.1093/jleuko/qiae222. Online ahead of print. ABSTRACT The liver has critical digestive, metabolic, and immunosurveillance roles, which get disrupted during liver diseases such as viral hepatitis, fatty liver disease, and hepatocellular carcinoma. While previous research on the pathological development of these diseases has focused on liver-resident immune populations, such … Read more

Neutrophils on the mast cell menuEric Espinosa on 8 de October de 2024 at 10:00

9 de October de 2024 by

J Leukoc Biol. 2024 Oct 8:qiae221. doi: 10.1093/jleuko/qiae221. Online ahead of print. ABSTRACT A recent article in Cell reported a new peculiar interaction between mast cells and neutrophils. Upon IgE/Ag-mediated degranulation, mast cells (MCs) produce leukotriene B4 (LTB4), which attracts migrating neutrophils. Some neutrophils are able to establish close contact with MCs and end up … Read more

B-cell Interleukin 1 Receptor 1 (IL1R1) modulates the female adipose tissue immune microenvironment during agingAnna Carey on 8 de October de 2024 at 10:00

9 de October de 2024 by

J Leukoc Biol. 2024 Oct 8:qiae219. doi: 10.1093/jleuko/qiae219. Online ahead of print. ABSTRACT Myeloid cell production of interleukin-1β (IL-1β) drives inflammaging in visceral adipose tissue (vWAT) and contributes to the expansion of interleukin-1 receptor 1 (Il1r1) positive aged adipose B-cells (AABs). AABs promote metabolic dysfunction and inflammation under inflammatory challenges. However, it is unclear whether … Read more