Journal of Leukocyte Biology

Potential functions of TRPM2 and TRPM7 channels in the tumor microenvironment​Irma Yadira Izaguirre-Hernández on 9 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9:qiaf098. doi: 10.1093/jleuko/qiaf098. Online ahead of print. ABSTRACT The tumor microenvironment (TME) is a complex and dynamic ecosystem consisting of both cellular and non-cellular components that collectively modulate the anti-tumor immune response, as well as cancer growth, invasion, metastasis, immune evasion, and resistance to therapy. Calcium (Ca2+) and magnesium (Mg2+) … Read more

Macrophage IL-4 polarization is restricted by soluble CD40 agonists and antigen-induced CD154 but not by constitutive CD154 expressed by CD4+ T cells​Mariana Suárez-Martins on 9 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9;117(7):qiaf069. doi: 10.1093/jleuko/qiaf069. ABSTRACT Stimulation of macrophages via CD40 promotes their classical activation. Therefore, CD154 (CD40 ligand) can be expected to oppose macrophage polarization and proliferation induced by IL-4. However, there are limited experimental data to support this, which is additionally complicated by the possibility of differential effects of CD40 … Read more

Transcriptional programs underlying human monocyte differentiation and diversity​Ravi K Komaravolu on 9 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9;117(7):qiaf058. doi: 10.1093/jleuko/qiaf058. ABSTRACT Classical monocytes (CD14hiCD16-) differentiate into intermediate monocytes (CD14+CD16+), which in turn yield nonclassical monocytes (CD14-CD16hi). To investigate the transcriptional regulation underlying this differentiation or conversion, we analyzed 3 single-cell RNA-sequencing datasets of peripheral mononuclear blood cells from healthy individuals using the single-cell regulatory network inference and … Read more

Myeloid-specific deficiency of ribosomal protein L13a alters macrophage polarity and diversity during differentiation from bone marrow​Antara Roy on 9 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 9:qiaf102. doi: 10.1093/jleuko/qiaf102. Online ahead of print. ABSTRACT Macrophages show substantial plasticity, leading to a diverse population of these cells with different states of polarization during differentiation from bone marrow. However, the mechanisms underlying this process are not well understood. Here, we identified a novel role of ribosomal protein L13a … Read more

Treponema pallidum lipoprotein TpF1 regulates METTL14-mediated NF-κB signaling pathway to promote macrophage M2 polarization​Qian Cao on 3 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 3:qiaf099. doi: 10.1093/jleuko/qiaf099. Online ahead of print. ABSTRACT During Treponema pallidum(T.pallidum) infection, m6A modification negatively regulates inflammatory responses in macrophages. However, whether m6A modification participates in the regulation of macrophage M2 polarization during T.pallidum infection remains unclear. Using THP-1-derived macrophages as a model, this study investigated the mechanism by which … Read more

Resolution of Innate Immune Cells with Pro-Resolving Lipid Mediators in Idiopathic Pulmonary Fibrosis​Yuet Ang on 3 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jul 3:qiaf100. doi: 10.1093/jleuko/qiaf100. Online ahead of print. ABSTRACT Idiopathic pulmonary fibrosis (IPF) is a progressive incurable lung disease characterized by chronic inflammation and fibrosis, with innate immune cells such as neutrophils and macrophages playing central roles in its pathogenesis. This review explores the involvement of these immune cells in the … Read more

Alpha-1 antitrypsin modulates neutrophil phenotype and function: implications for inflammatory regulation​Regina Oshins on 1 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 4;117(6):qiaf091. doi: 10.1093/jleuko/qiaf091. ABSTRACT Alpha-1 antitrypsin, the most abundant protease inhibitor within the plasma, plays a crucial role in regulating neutrophils’ function during inflammation. Alpha-1 antitrypsin deficiency is associated with excessive neutrophilic inflammation, yet the mechanisms underlying alpha-1 antitrypsin’s role in neutrophil trafficking remain poorly understood. Here, we demonstrate alpha-1 … Read more

Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis: a role for microRNAs?​Michele Fresneda Alarcon on 1 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 4;117(6):qiaf090. doi: 10.1093/jleuko/qiaf090. ABSTRACT Neutrophils are innate immune cells that drive the progression of rheumatoid arthritis through the release of reactive oxygen species, neutrophil extracellular traps, and proteases that damage host tissues. Neutrophil activation is regulated, in part, by dynamic changes in gene expression. In this study, we have used … Read more

Early increased monocyte-to-lymphocyte ratio as a potential biomarker of bacterial sepsis in patients with severe COVID-19​Edna Basilio-Gálvez on 1 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 4;117(6):qiaf064. doi: 10.1093/jleuko/qiaf064. ABSTRACT Monocytes are pivotal during inflammation. Sepsis added to COVID-19 increases mortality and inflammation. However, the role of monocytes in this condition is unclear. Our aim was to determine monocyte frequencies and HLA-DR expression related to size distribution in patients with severe COVID-19 with or without sepsis. … Read more

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