Journal of Leukocyte Biology

TLR-Mediated Calcium Signaling Regulates Killing Capacity of Expanded NK Cells: Challenges for Potential AML Immunotherapy​Vojtěch Graman on 23 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 23:qiag092. doi: 10.1093/jleuko/qiag092. Online ahead of print. ABSTRACT Natural killer (NK) cells are central to cancer immunosurveillance and immunotherapy. Their ability to engage in killing is critical for efficient target elimination and depends on tightly regulated Ca2+ signaling controlling granzyme degranulation. TLR engagement has been linked to Ca2+ signaling in … Read more

A DLL1-culture system to propagate murine patrolling monocytes from bone marrow progenitors​Jessica A F D Silva on 22 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 22:qiag103. doi: 10.1093/jleuko/qiag103. Online ahead of print. ABSTRACT Patrolling monocytes (pMos) scavenge debris from vessel walls and mediate antibody-dependent cellular phagocytosis, making them attractive cell therapy candidates for cancer, atherosclerosis, and Alzheimer’s disease. However, methods to generate enhanced numbers of pMos are not available. To address this, we developed a … Read more

From Sentinels to Soldiers: Tissue-Resident Cells for Next-Generation Immunotherapy​Nahuel Ko on 22 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 22:qiag102. doi: 10.1093/jleuko/qiag102. Online ahead of print. ABSTRACT Tissue-resident immune cells are specialized populations that survey peripheral tissues independently of circulating input. Their strategic positioning, persistence, and capacity for rapid local response make them key mediators of durable antitumor immunity. Although this biology has been most extensively defined in CD8+ … Read more

Lysosome-Induced Increase in Intracellular Granularity of Leukocytes: A Key Morphological Biomarker for Early Sepsis in Cell Population Data​Huan Qi on 16 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 16:qiag098. doi: 10.1093/jleuko/qiag098. Online ahead of print. ABSTRACT Early and rapid identification of sepsis is critical for improving clinical outcomes; however, reliable real-time biomarkers remain unavailable. The scattergram parameters of peripheral blood circulating leukocytes are altered during infection and sepsis. This study aims to explore the cellular biological characteristics underlying … Read more

A role for non-coding RNAs and alternative splicing in the regulation of neutrophil activation and gene expression in systemic lupus erythematosus​Grace Filbertine on 16 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 16:qiag100. doi: 10.1093/jleuko/qiag100. Online ahead of print. ABSTRACT Excess neutrophil apoptosis and the release of neutrophil extracellular traps (NETs) in systemic lupus erythematosus (SLE) leads to accumulation of cell debris and production of auto-antibodies targeting nuclear proteins and DNA. SLE neutrophil activation is regulated by changes in gene expression, notably … Read more

HS1 loss drives cytoskeletal dysregulation and reduces sensitivity to BTK inhibition in chronic lymphocytic leukemia​Luca Russo on 15 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 15:qiag099. doi: 10.1093/jleuko/qiag099. Online ahead of print. ABSTRACT Chronic lymphocytic leukemia (CLL) is a B-cell malignancy driven by aberrant signaling and microenvironmental support. Cytoskeletal remodeling contributes to these mechanisms, where the hematopoietic protein HS1 appears to play a key role. Thus, we generated C57BL/6 HS1 knockout (KO) mice to assess … Read more

Evaluation of T-cell Clonality by T-cell Constant β Chain (TRBC)1 and TRBC2 Expression Flow Cytometry in Hypereosinophilic Syndrome​Alejandra Sánchez-Santos on 13 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 13:qiag094. doi: 10.1093/jleuko/qiag094. Online ahead of print. ABSTRACT Hypereosinophilic syndrome (HES) is a rare hematopoietic disorder characterized by persistently elevated hypereosinophilia (HE) in peripheral blood and tissues, leading to multiorgan damage. HES can be classified into different subtypes based on diagnostic criteria and clinical characteristics: primary (neoplastic), secondary (reactive), idiopathic … Read more

rhIL-32γ Facilitates Macrophage Phagocytosis of Streptococcus pneumoniae by Activating NF-κB-Soluble Epoxide Hydrolase Pathway​Longying Liang on 10 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 10:qiag093. doi: 10.1093/jleuko/qiag093. Online ahead of print. ABSTRACT Interleukin (IL)-32 is recognized as a potent proinflammatory mediator in various infectious contexts, however, its precise contribution to host defense against Streptococcus pneumoniae (S. pneumoniae) remains to be fully elucidated. This study demonstrates that S. pneumoniae challenge robustly upregulates IL-32 expression in … Read more

DLL4+ Neutrophils Induce Alveolar Macrophages to Cause ADAM-17-mediated Endothelial Barrier Disruption and the Increase of ICAM1hiCXCR1lo Neutrophils in Sepsis​Hui Jin on 10 de July de 2026 at 10:00

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J Leukoc Biol. 2026 Jul 10:qiag097. doi: 10.1093/jleuko/qiag097. Online ahead of print. ABSTRACT Sepsis remains a leading cause of death. Reverse migrated (RM) neutrophils, characterized as ICAM1hiCXCR1lo, have been recognized as a key driver of systemic inflammation and organ injury in sepsis. We have recently discovered a distinct DLL4+ subset of neutrophils that accumulate in … Read more

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