Journal of Leukocyte Biology

High-dimensional single-cell mass cytometry analysis of IL-4 treated human macrophages reveals heterogeneity and a CD206high anticolitic subset​Blanca E Callejas on 29 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 8;118(6):qiag075. doi: 10.1093/jleuko/qiag075. ABSTRACT Autologous cell therapy is a patient-embraced approach to inflammatory disease. Murine models demonstrate that alternatively activated (or regulatory) macrophages can reduce the severity of disease, and human macrophages (M0) educated with interleukin-4 (M(IL4)) limit murine colitis. M0 and M(IL4) from healthy donors and individuals with Crohn’s … Read more

SHIP Blocks (MDP+LPS)-Induced Synergy in Macrophages Independent of Catalytic Activity​Yvonne C F Pang on 27 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 27:qiag090. doi: 10.1093/jleuko/qiag090. Online ahead of print. ABSTRACT Macrophages coordinate cytokine responses by integrating signals from pattern recognition receptors including NOD2 and TLR4. NOD2 detects muramyl dipeptide derived from bacterial peptidoglycan, and TLR4 recognizes lipopolysaccharide in the outer membrane of Gram-negative bacteria. NOD2 and TLR4 signals synergize to enhance cytokine … Read more

CD43: Recent Advances and Emerging Functions​Mariana Diupotex on 27 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 27:qiag084. doi: 10.1093/jleuko/qiag084. Online ahead of print. ABSTRACT Originally characterized for its roles in T-cell activation and adhesion, CD43 is a prominent mucin-like sialoglycoprotein expressed on hematopoietic cells. CD43 is broadly expressed across leukocyte populations, with its levels, molecular configuration, and ligand interactions varying by cell type, activation state, and … Read more

Sialylation Modulates Basophil Responsiveness to Galectin-3-dependent Activation​Laurent Ehrlich on 26 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 26:qiag087. doi: 10.1093/jleuko/qiag087. Online ahead of print. ABSTRACT Basophils secrete histamine and IL-4/13 when co-cultured with human lung adenocarcinoma cells (A549 cells). Previous studies have revealed that this interaction is dependent on Galectin-3 expression on the surface of A549 cells (EC-Gal-3), IgE present on the surface of IL-3 primed basophils, … Read more

Differences in the cell-wall architecture drive strain-specific IgA induction by Limosilactobacillus reuteri​Ran Lu on 25 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 25:qiag088. doi: 10.1093/jleuko/qiag088. Online ahead of print. ABSTRACT Limosilactobacillus reuteri (formerly Lactobacillus reuteri) is a well-studied commensal bacterium known for various health benefits. Our recent findings reveal that the human-derived strain L. reuteri CF48-3A enhances endogenous neonatal immunoglobulin A (IgA) production in mice. In a comparative analysis between the human … Read more

A TNFR2 biparatopic antagonist reverses immune suppression through a crosslinking-resistant and ADCC- independent mechanism​Shusu Liu on 24 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 24:qiag086. doi: 10.1093/jleuko/qiag086. Online ahead of print. ABSTRACT Tumor necrosis factor receptor 2 (TNFR2) is a promising immunotherapeutic target due to its high upregulation on immunosuppressive populations, like regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs). The clinical efficacy of conventional bivalent TNFR2 antagonists, such as BI1808, is fundamentally … Read more

High CD163+CD206+macrophages infiltration in the bone marrow microenvironment of newly diagnosed multiple myeloma patients​Dong-Hai Han on 23 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 23:qiag076. doi: 10.1093/jleuko/qiag076. Online ahead of print. ABSTRACT Multiple myeloma (MM) is a neoplastic disease caused by abnormal clonal plasma cells (PCs) in the bone marrow (BM). Macrophages(MФs) are essential components of BM microenvironment and crucial mediators of PCs. Therefore, investigating alterations in the specific MФ subsets within the MM … Read more

An optimized method to differentiate HL60 cells into neutrophil-like cells​Samuel P Collie on 22 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 22:qiag081. doi: 10.1093/jleuko/qiag081. Online ahead of print. ABSTRACT The HL60 promyelocytic leukemia cell line is widely used to investigate neutrophil biology due to its genetic tractability and accessibility. HL60 cells can be differentiated into neutrophil-like cells using all-trans retinoic acid (ATRA) or dimethyl sulfoxide (DMSO) treatment. However, these approaches produce … Read more

The anti-CD33 antibody drug conjugate gemtuzumab ozogamicin depletes and functionally resets CD33+ myeloid-derived suppressor cells in patients with metastatic cancer: a phase II single arm, open label trial​Carmela De Santo on 18 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 18:qiag083. doi: 10.1093/jleuko/qiag083. Online ahead of print. ABSTRACT We previously demonstrated that the anti-CD33 antibody drug conjugate, gemtuzumab ozogamicin (GO) binds CD33-expressing monocytic myeloid-derived suppressor cells (M-MDSCs), is internalised, and decreases their viability. Treatment of MDSCs with GO restores T-cell proliferation in co-culture, overcomes M-MDSC suppression of CAR-T-cell proliferation, and … Read more

HIF-1α in macrophage polarization: roles in immunometabolism and autoimmune diseases​Dongye Li on 18 de June de 2026 at 10:00

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J Leukoc Biol. 2026 Jun 18:qiag082. doi: 10.1093/jleuko/qiag082. Online ahead of print. ABSTRACT Hypoxia-inducible factor-1α (HIF-1α) is a central regulator of cellular responses to hypoxia and plays a pivotal role in immune cell activation and functional reprogramming. This review summarizes how HIF-1α modulates inflammatory responses through metabolic regulation and examines its mechanistic involvement in autoimmune … Read more

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