Journal of Leukocyte Biology

J Leukoc Biol. 2024 Nov 12:qiae240. doi: 10.1093/jleuko/qiae240. Online ahead of print. ABSTRACT Trained immunity induces antigen-agnostic enhancement of host defense and protection against secondary infections, but inappropriate activation can contribute to the pathophysiology of inflammatory diseases. Tight regulation of trained immunity is therefore needed to avoid pathology, but little is known about the endogenous … Read more

J Leukoc Biol. 2024 Nov 6:qiae245. doi: 10.1093/jleuko/qiae245. Online ahead of print. ABSTRACT Basic leucine zipper transcription factor ATF-like 2 (BATF2) is a transcription factor that is known to exhibit tumor-suppressive activity in cancer cells. Within recent years, however, BATF2 has also emerged as an important transcriptional regulator of the immune system. Through its immunomodulatory … Read more

J Leukoc Biol. 2024 Nov 6:qiae243. doi: 10.1093/jleuko/qiae243. Online ahead of print. ABSTRACT During sterile inflammation, tissue damage induces excessive activation and infiltration of neutrophils into tissues, where they critically contribute to organ dysfunction. Tight regulation of neutrophil migration and their effector functions is crucial to prevent overshooting immune responses. Neutrophils utilize more glutamine, the … Read more

J Leukoc Biol. 2024 Nov 6:qiae244. doi: 10.1093/jleuko/qiae244. Online ahead of print. ABSTRACT Atopic dermatitis (AD) is a complex disease influenced by alterations in the skin microbiome and immune dysregulation. Despite the recognized role of these factors, the specific pathways by which distinct microbial populations affect skin immunity remain insufficiently understood. On a molecular level, … Read more

J Leukoc Biol. 2024 Nov 4:qiae241. doi: 10.1093/jleuko/qiae241. Online ahead of print. ABSTRACT Resveratrol is a natural polyphenol derived from plants such as grapes and berries. In addition to its role in plants during injury and infection, various cardioprotective, neuroprotective, and longevity-promoting effects were reported in diverse model organisms. The primary target of resveratrol is … Read more

J Leukoc Biol. 2024 Nov 4:qiae242. doi: 10.1093/jleuko/qiae242. Online ahead of print. ABSTRACT Piezo1 is a mechanosensitive, nonselective Ca2+ channel which is broadly expressed in CD4+ T cells. Using lineage-specific Piezo1 knockout mice (Piezo1cKO), we show that loss of Piezo1 in CD4+ T cells significantly increased IFNγ and IL-17 production in vitro under TH1 and … Read more

J Leukoc Biol. 2024 Oct 29:qiae234. doi: 10.1093/jleuko/qiae234. Online ahead of print. NO ABSTRACT PMID:39471419 | DOI:10.1093/jleuko/qiae234

J Leukoc Biol. 2024 Oct 26:qiae235. doi: 10.1093/jleuko/qiae235. Online ahead of print. ABSTRACT Neutrophil extracellular traps (NETs) are promising promoters in venous thromboembolism (VTE). In the present study, we have investigated the potential thrombogenic role of NETs in colorectal cancer (CRC). A total of 583 patients with gastrointestinal malignancies who were diagnosed with or without … Read more

J Leukoc Biol. 2024 Oct 25:qiae227. doi: 10.1093/jleuko/qiae227. Online ahead of print. ABSTRACT Natural Killer (NK) cells are critical innate immune cells involved in the clearance of virally infected and malignant cells. Human NK cells are distinguished by their surface expression of CD56 and a lack of CD3. While CD56 expression and cell surface density … Read more

J Leukoc Biol. 2024 Oct 24:qiae232. doi: 10.1093/jleuko/qiae232. Online ahead of print. ABSTRACT Blood and airway eosinophilia represent markers for the endotype-driven treatment of allergic asthma. Little is known on mechanisms that link eosinophils and airway epithelial cells before and after these cells are infiltrated by eosinophils during allergic response. Given that innate immune mechanisms, … Read more