Journal of Leukocyte Biology – Page 21

Limited proteolysis of neutrophil granule proteins by the bacterial protease RgpB depletes neutrophil antimicrobial capacity. Kelley N Cooper

29 de September de 2024 by inmunoadmin

J Leukoc Biol. 2024 Sep 25:qiae209. doi: 10.1093/jleuko/qiae209. Online ahead of print. ABSTRACT Neutrophils are highly abundant in the gingival tissues where they play an essential role in immune homeostasis by preventing microbial invasion. Here, we show that the oral periodontal pathogen Porphyromonas gingivalis utilizes its cysteine proteases (gingipains) to disengage phagosomal antimicrobial capacity. Arginine … Read more

The 129 strain-derived passenger mutations in ACKR1-deficient mice alter the expression of PYHIN and Fc-gamma receptor genes. Zoe Möller-Ramon

29 de September de 2024 by inmunoadmin

J Leukoc Biol. 2024 Sep 25:qiae208. doi: 10.1093/jleuko/qiae208. Online ahead of print. ABSTRACT A majority of genetically modified mice have been produced using 129 strain-derived embryonic stem cells (ESCs). Despite ample backcrosses with other strains, these may retain characteristic for 129 passenger mutations leading to confounding phenotypes unrelated to targeted genes. Here we show that … Read more

Dendritic cell-specific deletion of PKCδ in offspring of allergic mothers prevents the predisposition for development of allergic lung inflammation in offspring. Jacquelyn D Lajiness

29 de September de 2024 by inmunoadmin

J Leukoc Biol. 2024 Sep 23:qiae207. doi: 10.1093/jleuko/qiae207. Online ahead of print. ABSTRACT In humans and in mice, maternal allergy predisposes offspring to development of allergy. In murine models, increased levels of maternal β-glucosylceramides are both necessary and sufficient for the development of allergic predisposition in offspring. Furthermore, increased numbers of CD11b+ dendritic cell subsets … Read more

Neonatal neutrophils exhibit reduced NLRP3 inflammasome activation. Lou Martha Wackerbarth

29 de September de 2024 by inmunoadmin

J Leukoc Biol. 2024 Sep 23:qiae206. doi: 10.1093/jleuko/qiae206. Online ahead of print. ABSTRACT Newborns are at high risk to develop sepsis. This is linked to innate immune responses at birth which are not completely adapted to postnatal life. Neutrophils are key players of innate immunity and exhibit a marked ontogenetic regulation of their functionality. Here, … Read more

Blood immune profiles reveal a CXCR3/CCR5 axis of dysregulation in early sepsis. David Kealy

29 de September de 2024 by inmunoadmin

J Leukoc Biol. 2024 Sep 23:qiae204. doi: 10.1093/jleuko/qiae204. Online ahead of print. ABSTRACT We report on a pilot study exploring whether blood immune signatures can reveal early specific indicator profiles for patients meeting sepsis criteria upon hospital admission. We analysed samples of sepsis-suspected patients (N=20) and age-spanning healthy controls (N=12), using flow cytometry-based assays. We … Read more

IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration. Alessandro Cutilli

29 de September de 2024 by inmunoadmin

J Leukoc Biol. 2024 Sep 20:qiae205. doi: 10.1093/jleuko/qiae205. Online ahead of print. ABSTRACT The cytokine interferon-gamma (IFNγ) plays a multifaceted role in intestinal immune responses ranging from anti- to pro-inflammatory depending on the setting. Here, using a 3D co-culture system based on human intestinal epithelial organoids, we explore the capacity of IFNγ-exposure to reprogram intestinal … Read more