J Leukoc Biol. 2025 Jan 21:qiaf009. doi: 10.1093/jleuko/qiaf009. Online ahead of print. ABSTRACT Macrophages play a crucial role in the immune response during allograft rejection in organ transplantation. Therefore, our study aimed to explore the genomic features of macrophages in mouse heart transplants and use single-cell RNA sequencing to investigate Galectin-9 (Gal-9, Lgals9), a lectin … Read more

J Leukoc Biol. 2025 Jan 21:qiaf004. doi: 10.1093/jleuko/qiaf004. Online ahead of print. ABSTRACT The gastrointestinal tract is a remarkable example of complex biology, with a constant dialogue between the intestinal epithelium, in close contact with the microbiota, and the immune cells that protect the gut from infection. Organoids have revolutionized our approach to modelling the … Read more

J Leukoc Biol. 2025 Jan 20:qiaf008. doi: 10.1093/jleuko/qiaf008. Online ahead of print. ABSTRACT Osteoporosis is a skeletal condition characterized by the deterioration of bone tissue. The immune system plays a crucial role in maintaining bone homeostasis and combating the development of osteoporosis. Immunoporosis is the term used to describe the recent convergence of research on … Read more

J Leukoc Biol. 2025 Jan 18:qiaf003. doi: 10.1093/jleuko/qiaf003. Online ahead of print. ABSTRACT Pediatric intensive care patients are particularly susceptible to severe bacterial infections because of ineffective neutrophil responses. The reasons why neutrophils of newborns are less responsive than those of adults are not clear. Because adenosine triphosphate (ATP) and adenosine (ADO) tightly regulate neutrophils, … Read more

J Leukoc Biol. 2025 Jan 17:qiaf005. doi: 10.1093/jleuko/qiaf005. Online ahead of print. ABSTRACT Murine neonatal neutrophil depletion strategies have problems achieving deep neutrophil clearance and accurate residual neutrophil fraction detection. An isotype switch method can achieve profound neutrophil clearance using a combination of anti-Ly6G and anti-rat κ Ig light chain antibodies in adult C57Bl/6 mice, … Read more

J Leukoc Biol. 2025 Jan 8:qiaf001. doi: 10.1093/jleuko/qiaf001. Online ahead of print. ABSTRACT The thymus is a primary lymphoid organ where major types of T lymphocytes undergo essential developmental processes. Eosinophils are among the cell types present in microenvironments within the thymus, and perhaps surprisingly, the role of thymic eosinophils, especially during homeostatic conditions, remains … Read more

J Leukoc Biol. 2025 Jan 6:qiaf002. doi: 10.1093/jleuko/qiaf002. Online ahead of print. ABSTRACT In tissues, neutrophils neutralize Candida albicans through phagocytosis and delay C. albicans hyphae growth by deploying neutrophil extracellular traps (NETs). However, in the bloodstream, the dynamic interactions between NETs and C. albicans are far less understood. Here, we employ a microfluidic assay … Read more

J Leukoc Biol. 2024 Dec 31:qiae257. doi: 10.1093/jleuko/qiae257. Online ahead of print. ABSTRACT Regulatory T cells can suppress activated T cell proliferation by direct cell-contact, although the exact mechanism is poorly understood. Identification of a Treg-specific cell surface molecule that mediates suppression would offer a unique target for cancer immunotherapy to inhibit Treg immunosuppressive function … Read more

J Leukoc Biol. 2024 Dec 26:qiae259. doi: 10.1093/jleuko/qiae259. Online ahead of print. ABSTRACT Aging significantly increases the incidence and severity of infections, with individuals aged 65 and above accounting for 65% of sepsis cases. Innate immune training, known as “trained immunity” or “innate immune memory”, has emerged as a potential strategy to enhance infection resistance … Read more

J Leukoc Biol. 2024 Dec 26:qiae260. doi: 10.1093/jleuko/qiae260. Online ahead of print. ABSTRACT NR2F6 has emerged as a key player in immune regulation, especially in cancer immunity. It has indeed been reported that NR2F6 could suppress the anti-tumor immune response, and has therefore been suggested as possible target in cancer immunotherapy. In this review, we … Read more