Journal of Leukocyte Biology

Early increased monocyte-to-lymphocyte ratio as a potential biomarker of bacterial sepsis in patients with severe COVID-19​Edna Basilio-Gálvez on 1 de July de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 4;117(6):qiaf064. doi: 10.1093/jleuko/qiaf064. ABSTRACT Monocytes are pivotal during inflammation. Sepsis added to COVID-19 increases mortality and inflammation. However, the role of monocytes in this condition is unclear. Our aim was to determine monocyte frequencies and HLA-DR expression related to size distribution in patients with severe COVID-19 with or without sepsis. … Read more

Berbamine promotes autophagy and GPX4 expression through inducing abundant ROS to restrict HIV-1 and Mtb coinfection in macrophages​Xuefeng Zhou on 28 de June de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 23:qiaf095. doi: 10.1093/jleuko/qiaf095. Online ahead of print. ABSTRACT Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium tuberculosis (Mtb) co-infection poses a significant public health threat, characterized by a high mortality rate due to impaired host immune responses. In this study, we investigated the role of autophagy, primarily using macrophage cell … Read more

The Universal Receptive System: A Novel Regulator of Antimicrobial and Anticancer Compound Production by White Blood Cells​Victor Tetz on 27 de June de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 20:qiaf085. doi: 10.1093/jleuko/qiaf085. Online ahead of print. ABSTRACT Despite recent advances, the regulation of anticancer and antimicrobial bioactive compound (AABC) production by leukocytes remains poorly understood. Here, we demonstrate that inactivation of the DNA- and RNA-based Teazeled receptors of the Universal Receptive System in human leukocytes generated so called “Leukocyte-Tells,” … Read more

Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis. A role for microRNAs?​Michele Fresneda Alarcon on 27 de June de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 18:qiaf090. doi: 10.1093/jleuko/qiaf090. Online ahead of print. ABSTRACT Neutrophils are innate immune cells that drive the progression of rheumatoid arthritis (RA) through the release of reactive oxygen species (ROS), neutrophil extracellular traps (NETs) and proteases that damage host tissues. Neutrophil activation is regulated, in part, by dynamic changes in gene … Read more

KMT2D upregulates SMG1 via histone methylation to antagonize mTOR and reinforce DLBCL ferroptosis​Yongcheng Sun on 27 de June de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 19:qiaf092. doi: 10.1093/jleuko/qiaf092. Online ahead of print. ABSTRACT Diffuse large B-cell lymphoma (DLBCL) is highly heterogeneous and prone to epigenetic mutations. Non-apoptotic cell death pathways, especially ferroptosis, have become an emerging direction for cancer treatment. This project was designed to probe into the potential of histone-lysine N-methyltransferase 2D (KMT2D) in … Read more

Downregulation of miR-93 Inhibits Proliferation and Promotes Apoptosis and Hematopoiesis in Myelodysplastic Syndrome Cells through PAG1-Mediated EGFR Signaling Pathway​Junyu Liu on 27 de June de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 18:qiaf083. doi: 10.1093/jleuko/qiaf083. Online ahead of print. ABSTRACT MicroRNA-93 (miR-93) has been implicated in the pathogenesis of myelodysplastic syndrome (MDS), though its precise role in the regulation of hematopoiesis and cell fate in MDS remains poorly understood. This study aimed to investigate the impact of miR-93 on cell proliferation, apoptosis, … Read more

Pre-Ligand Assembly Domain-Derived Recombinant Proteins of TNFR2 Inhibits the Expansion of CD4+Foxp3+ Regulatory T Cells​Wen-Wei Li on 27 de June de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 18:qiaf087. doi: 10.1093/jleuko/qiaf087. Online ahead of print. ABSTRACT There is compelling evidence that tumor necrosis factor (TNF) receptor type II (TNFR2) mediates the stimulatory effect of TNF on the activation of CD4+Foxp3+ regulatory T cells (Tregs). Tregs with high TNFR2 expression are critical components of tumor microenvironment (TME), where they … Read more

Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2/TLR4-activated dendritic cells​Sara Zúquete on 27 de June de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 27:qiaf096. doi: 10.1093/jleuko/qiaf096. Online ahead of print. ABSTRACT Toll-like receptor (TLR)2 activation induces aldehyde dehydrogenase enzymes in non-mucosal dendritic cells (DCs) enabling them to metabolize vitamin A into all-trans retinoic acid, which induces the expression of mucosal-homing molecules (α4β7 and CCR9) in the activated T cells. Recently, we have shown … Read more

Sex-specific Leukocyte Responses to Peanut Allergen: Uncovering Potential Links to the Molecular Circadian Clock​Santhosh Kumar Duraisamy on 27 de June de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 27:qiaf097. doi: 10.1093/jleuko/qiaf097. Online ahead of print. ABSTRACT Food allergies, particularly peanut allergies, are on the rise, affecting ∼10% of the U.S. population and 17% of adults. We explored sex-based differences in inflammatory responses to peanut allergens using a mouse model. Female mice exhibited severe allergic symptoms and a greater … Read more

Megakaryocyte emperipolesis in myeloproliferative neoplasms: are neutrophils friends or foes?​Ryan J Collinson on 25 de June de 2025 at 10:00

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J Leukoc Biol. 2025 Jun 25:qiaf093. doi: 10.1093/jleuko/qiaf093. Online ahead of print. ABSTRACT Megakaryocyte emperipolesis is a biological process in which a cell penetrates and exists as a viable intact cell within another. It is a recognized morphological feature of myeloproliferative neoplasms (MPN), where neutrophils can be seen within megakaryocytes in bone marrow smears and … Read more

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