Journal of Leukocyte Biology

E26 transformation-specific-1 controls asthma development by regulating the CD4+ Th2/Th17 immune response involved transcription factors in active genomic transcriptional regions​Kai-Cheng Gao on 15 de May de 2025 at 10:00

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J Leukoc Biol. 2025 May 7;117(5):qiaf032. doi: 10.1093/jleuko/qiaf032. ABSTRACT Asthma is a chronic respiratory disease characterized by airway inflammation and immune cell imbalance. The transcription factor E26 transformation-specific-1 regulates immune cell functions, but its role in asthma remains unclear. Here, we generated Ets1 heterozygous (Ets1+/-) mice by constitutively knocking out exons 7 and 8 of … Read more

Fever-range temperature alters continual efferocytosis mediated by mouse pro-inflammatory macrophages​Mathieu Vetter on 14 de May de 2025 at 10:00

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J Leukoc Biol. 2025 May 14:qiaf061. doi: 10.1093/jleuko/qiaf061. Online ahead of print. ABSTRACT Fever, a cardinal sign of inflammation, has been shown to modulate macrophage functions. Here, we investigate whether fever affects macrophage efferocytosis. This process is essential for the resolution of inflammation and the return to homeostasis with the reprogramming of macrophages towards a … Read more

Two-sided Effects of Neutrophil Extracellular Traps and Changes in the Myeloid Compartment in Acute Covid-19: A Histopathological Study on Autopsy Cases from the First and Second Covid-19 Waves in Switzerland​Nina Anzic on 13 de May de 2025 at 10:00

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J Leukoc Biol. 2025 May 13:qiaf056. doi: 10.1093/jleuko/qiaf056. Online ahead of print. ABSTRACT Severe COVID-19 is characterized by complex immunopathology that involves inflammation, endothelial dysfunction and immunothrombosis. Neutrophil extracellular traps (NETs) have been recognized as key factors in the severity of the disease, with their emergence correlating to viral load, immmunothrombosis and organ damage. In … Read more

Impaired LPS Tolerance in Monocytes of Coronary Atherosclerosis Patients Is Associated with the Intermediate Subset​Nikita G Nikiforov on 11 de May de 2025 at 10:00

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J Leukoc Biol. 2025 May 12:qiaf060. doi: 10.1093/jleuko/qiaf060. Online ahead of print. ABSTRACT Endotoxin tolerance in monocytes is a mechanism that reduces the secretion of inflammatory cytokines upon repeated pathogen exposure, thereby protecting tissues from hyperinflammation. Previously, we demonstrated that monocytes from patients with asymptomatic carotid atherosclerosis exhibit impaired LPS tolerance. In this study, we … Read more

Chinese Herbal Extracts Mediated Programmed Cell Death in Cancer and Inflammation Therapy​Haihong Yu on 2 de May de 2025 at 10:00

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J Leukoc Biol. 2025 May 2:qiaf051. doi: 10.1093/jleuko/qiaf051. Online ahead of print. ABSTRACT Programmed cell death (PCD) is a common phenomenon in the development of organisms. It is an active and orderly mode of cell death determined by genes. PCD is usually classified into three different types according to the cell morphological changes, stimulus and … Read more

Secretory IgA binding to FCRL3 triggers shared inflammatory cytokine secretion by human regulatory T cells and effector T cells​Zachary Kraus on 2 de May de 2025 at 10:00

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J Leukoc Biol. 2025 May 2:qiaf054. doi: 10.1093/jleuko/qiaf054. Online ahead of print. ABSTRACT Several human lymphocyte subsets express the novel secretory IgA receptor FCRL3. Secretory IgA binding to FCRL3 diminishes the inhibitory capacity of regulatory T cells and promotes a Th17-like phenotype. Here we report that in CD4+ regulatory T cells and CD8+ terminal effector … Read more

Depression-like behavior is associated with changes in the meningeal lymphatic vasculature and meningeal B cells in a murine lupus model​Alexandra Olate-Briones on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23;117(4):qiaf016. doi: 10.1093/jleuko/qiaf016. ABSTRACT Meningeal lymphatic vasculature (mLV) comprises a network of vessels responsible for draining immune cells and fluid from the central nervous system (CNS) into the deep cervical lymph nodes. While changes in mLV function have been implicated in several neurodegenerative disorders, its role in autoimmune diseases is … Read more

Protective function of ex vivo-expanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expression​Xiaokun Liu on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23;117(4):qiae256. doi: 10.1093/jleuko/qiae256. ABSTRACT The adoptive transfer of virus-specific T cells (VSTs) represents a therapeutic option for viral infection treatment in immunocompromised patients. Before administration, ex vivo culture enables VST expansion. However, it is unclear how ex vivo expansion affects the circulation, homing, and intra-tissue migration of administered VSTs. We … Read more

Different behavior of NK cells isolated from healthy women and women with recurrent spontaneous abortion after treatment with human amniotic epithelial cells​Fatemeh Rezayat on 25 de April de 2025 at 10:00

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J Leukoc Biol. 2025 Apr 23;117(4):qiaf020. doi: 10.1093/jleuko/qiaf020. ABSTRACT Maternal immunotolerance during pregnancy is heavily dependent on the critical properties of human amniotic epithelial cells (hAECs). Recurrent spontaneous abortion (RSA) is one of the most common diseases in women and is caused by feto-maternal immunotolerance disruption. The objective of this study is to investigate how … Read more

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