Journal of Leukocyte Biology

J Leukoc Biol. 2025 Jun 25:qiaf088. doi: 10.1093/jleuko/qiaf088. Online ahead of print. ABSTRACT Liver macrophages play important roles in the pathophysiology of liver fibrosis and hepatocellular carcinoma (HCC). However, liver macrophages are a heterogenous population and have differing roles in maintenance of liver function and response in disease. In a healthy liver, macrophages play a … Read more

J Leukoc Biol. 2025 Jun 25:qiaf094. doi: 10.1093/jleuko/qiaf094. Online ahead of print. ABSTRACT Overnutrition and the consumption of Western-type diets lead to chronic low-grade systemic inflammation (i.e., metainflammation) and a dysfunctional immune response. Although neutrophils are affected by metainflammation, mechanistic evidence regarding the direct effects of dietary fat exposure on neutrophil function and migration in … Read more

J Leukoc Biol. 2025 Jun 4;117(6):qiaf072. doi: 10.1093/jleuko/qiaf072. ABSTRACT Increasing numbers of clinical cohorts have detected CCND2 mutations in acute myeloid leukemia, especially in the subtype of acute myeloid leukemia with the t(8;21) translocation. This acute myeloid leukemia subtype is characterized by the formation of the AML1-ETO fusion gene. However, the AML1-ETO fusion gene alone … Read more

J Leukoc Biol. 2025 Jun 6:qiaf081. doi: 10.1093/jleuko/qiaf081. Online ahead of print. ABSTRACT While chronic alcohol use is proinflammatory, the immune effects of acute intake remain unclear. We examined granulocyte responses to binge drinking, common in youth. Twenty-two volunteers consumed 12 alcoholic drinks over 4h (BAC 1.0‰). Blood was collected at baseline (T0), 2h (T2), … Read more

J Leukoc Biol. 2025 Jun 6:qiaf082. doi: 10.1093/jleuko/qiaf082. Online ahead of print. ABSTRACT Neutrophils utilize many mechanisms to restrict fungal growth. When phagocytosis occurs, neutrophils can create many toxic antimicrobials including reactive oxygen species and the products of myeloperoxidase (MPO). If a pathogen is too large to phagocytose, neutrophils can also resort to the release … Read more

J Leukoc Biol. 2025 Jun 4;117(6):qiaf075. doi: 10.1093/jleuko/qiaf075. NO ABSTRACT PMID:40465865 | DOI:10.1093/jleuko/qiaf075

J Leukoc Biol. 2025 Jun 4:qiaf080. doi: 10.1093/jleuko/qiaf080. Online ahead of print. ABSTRACT Trained immunity, also termed innate immune memory, is supported by metabolic rewiring of innate immune cells, altering their bioenergetic profile and ultimately their functions. While amino acids such as arginine are known to possess immunomodulatory properties, their role in trained immunity remains … Read more

J Leukoc Biol. 2025 Jun 3:qiaf078. doi: 10.1093/jleuko/qiaf078. Online ahead of print. ABSTRACT Neutrophils are the first line of host defense. Neutrophils target invading pathogens by phagocytosis, generation of reactive oxygen species (ROS), neutrophil extracellular trap formation (NETosis) and cytokine production. Interferon regulatory factor 8 (IRF8) plays a central role in the regulation of myeloid … Read more

J Leukoc Biol. 2025 May 28:qiaf077. doi: 10.1093/jleuko/qiaf077. Online ahead of print. ABSTRACT Transcription factors TFEB and TFE3 are crucial for regulating autophagy, lysosomal biogenesis, and lipid metabolism, and have significant roles in macrophage function and innate immunity. The alpha7 nicotinic acetylcholine receptor (α7nAChR), a ligand-gated Ca2+ channel known for its therapeutic potential in neurological … Read more

J Leukoc Biol. 2025 May 28:qiaf076. doi: 10.1093/jleuko/qiaf076. Online ahead of print. ABSTRACT Neutrophil release of cytoplasmic granules containing antimicrobial agents is a critical component of innate immunity. Neutrophils are widely implicated in tissue inflammation however the extent of the neutrophil contribution to human health and disease is incompletely characterized. To explore this further, we … Read more