Journal of Leukocyte Biology

J Leukoc Biol. 2025 May 19:qiaf057. doi: 10.1093/jleuko/qiaf057. Online ahead of print. ABSTRACT Optimal antimicrobial action of human neutrophils (PMN) relies on the synergy of oxidants and granule proteins, most notably that between the granule protein myeloperoxidase (MPO) and hydrogen peroxide (H2O2) to oxidize chloride anion to produce the potent microbicide, hypochlorous acid (HOCl). However, … Read more

J Leukoc Biol. 2025 May 16:qiaf068. doi: 10.1093/jleuko/qiaf068. Online ahead of print. ABSTRACT Neuromyelitis optica spectrum disorder (NMOSD) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects the optic nerves, spinal cord, and brainstem, leading to severe relapses and potentially significant neurological disability. Most NMOSD patients present with anti-aquaporin-4 … Read more

J Leukoc Biol. 2025 May 16:qiaf065. doi: 10.1093/jleuko/qiaf065. Online ahead of print. ABSTRACT Hypoxia-associated H2S accumulation promotes chemotherapy resistance in solid tumor cells. This study delved into the mechanism by which CBS/H2S signaling is involved in the development of acute myeloid leukemia (AML) resistance to cytarabine (ara-C) under hypoxic conditions. The levels of CBS and … Read more

J Leukoc Biol. 2025 May 16:qiaf063. doi: 10.1093/jleuko/qiaf063. Online ahead of print. ABSTRACT Sepsis is a life-threatening condition caused by a dysregulated immune response to infection. Neutrophils act as first line of defense against infection, but their function can become impaired in sepsis. CD300 antigen-like family member d (CD300ld), predominantly expressed on neutrophils, associates with … Read more

J Leukoc Biol. 2025 May 7;117(5):qiaf032. doi: 10.1093/jleuko/qiaf032. ABSTRACT Asthma is a chronic respiratory disease characterized by airway inflammation and immune cell imbalance. The transcription factor E26 transformation-specific-1 regulates immune cell functions, but its role in asthma remains unclear. Here, we generated Ets1 heterozygous (Ets1+/-) mice by constitutively knocking out exons 7 and 8 of … Read more

J Leukoc Biol. 2025 May 7;117(5):qiaf028. doi: 10.1093/jleuko/qiaf028. NO ABSTRACT PMID:40372771 | DOI:10.1093/jleuko/qiaf028

J Leukoc Biol. 2025 May 14:qiaf061. doi: 10.1093/jleuko/qiaf061. Online ahead of print. ABSTRACT Fever, a cardinal sign of inflammation, has been shown to modulate macrophage functions. Here, we investigate whether fever affects macrophage efferocytosis. This process is essential for the resolution of inflammation and the return to homeostasis with the reprogramming of macrophages towards a … Read more

J Leukoc Biol. 2025 May 13:qiaf056. doi: 10.1093/jleuko/qiaf056. Online ahead of print. ABSTRACT Severe COVID-19 is characterized by complex immunopathology that involves inflammation, endothelial dysfunction and immunothrombosis. Neutrophil extracellular traps (NETs) have been recognized as key factors in the severity of the disease, with their emergence correlating to viral load, immmunothrombosis and organ damage. In … Read more

J Leukoc Biol. 2025 May 12:qiaf060. doi: 10.1093/jleuko/qiaf060. Online ahead of print. ABSTRACT Endotoxin tolerance in monocytes is a mechanism that reduces the secretion of inflammatory cytokines upon repeated pathogen exposure, thereby protecting tissues from hyperinflammation. Previously, we demonstrated that monocytes from patients with asymptomatic carotid atherosclerosis exhibit impaired LPS tolerance. In this study, we … Read more

J Leukoc Biol. 2025 May 2:qiaf051. doi: 10.1093/jleuko/qiaf051. Online ahead of print. ABSTRACT Programmed cell death (PCD) is a common phenomenon in the development of organisms. It is an active and orderly mode of cell death determined by genes. PCD is usually classified into three different types according to the cell morphological changes, stimulus and … Read more