Journal of Leukocyte Biology

J Leukoc Biol. 2025 Jun 6:qiaf082. doi: 10.1093/jleuko/qiaf082. Online ahead of print. ABSTRACT Neutrophils utilize many mechanisms to restrict fungal growth. When phagocytosis occurs, neutrophils can create many toxic antimicrobials including reactive oxygen species and the products of myeloperoxidase (MPO). If a pathogen is too large to phagocytose, neutrophils can also resort to the release … Read more

J Leukoc Biol. 2025 Jun 4;117(6):qiaf075. doi: 10.1093/jleuko/qiaf075. NO ABSTRACT PMID:40465865 | DOI:10.1093/jleuko/qiaf075

J Leukoc Biol. 2025 Jun 4:qiaf080. doi: 10.1093/jleuko/qiaf080. Online ahead of print. ABSTRACT Trained immunity, also termed innate immune memory, is supported by metabolic rewiring of innate immune cells, altering their bioenergetic profile and ultimately their functions. While amino acids such as arginine are known to possess immunomodulatory properties, their role in trained immunity remains … Read more

J Leukoc Biol. 2025 Jun 3:qiaf078. doi: 10.1093/jleuko/qiaf078. Online ahead of print. ABSTRACT Neutrophils are the first line of host defense. Neutrophils target invading pathogens by phagocytosis, generation of reactive oxygen species (ROS), neutrophil extracellular trap formation (NETosis) and cytokine production. Interferon regulatory factor 8 (IRF8) plays a central role in the regulation of myeloid … Read more

J Leukoc Biol. 2025 May 28:qiaf077. doi: 10.1093/jleuko/qiaf077. Online ahead of print. ABSTRACT Transcription factors TFEB and TFE3 are crucial for regulating autophagy, lysosomal biogenesis, and lipid metabolism, and have significant roles in macrophage function and innate immunity. The alpha7 nicotinic acetylcholine receptor (α7nAChR), a ligand-gated Ca2+ channel known for its therapeutic potential in neurological … Read more

J Leukoc Biol. 2025 May 28:qiaf076. doi: 10.1093/jleuko/qiaf076. Online ahead of print. ABSTRACT Neutrophil release of cytoplasmic granules containing antimicrobial agents is a critical component of innate immunity. Neutrophils are widely implicated in tissue inflammation however the extent of the neutrophil contribution to human health and disease is incompletely characterized. To explore this further, we … Read more

J Leukoc Biol. 2025 May 27:qiaf074. doi: 10.1093/jleuko/qiaf074. Online ahead of print. ABSTRACT Neutrophils are traditionally known as short-lived pathogen-killing cells, but recent work published in Nature by Hidalgo and colleagues uncovers a novel role for neutrophils in maintaining skin integrity. Using transcriptomics, imaging, and genetic models, the study reveals that skin-infiltrating neutrophils produce collagen, … Read more

J Leukoc Biol. 2025 May 24:qiaf073. doi: 10.1093/jleuko/qiaf073. Online ahead of print. ABSTRACT Immune-mediated bone marrow failure (BMF) entails a complex immune landscape. Myeloid cells, including monocytes, macrophages, and myeloid-derived suppressor cells (MDSCs), are involved in the development and progression of immune aplastic anemia (AA). We used a murine model of BMF to explore the … Read more

J Leukoc Biol. 2025 May 7;117(5):qiaf035. doi: 10.1093/jleuko/qiaf035. ABSTRACT In the early COVID-19 pandemic, the strain on healthcare facilities highlighted the need for reliable biomarkers to predict progression to severe COVID-19. Neutrophils, the most abundant leukocytes in circulation, are early defenders against pathogens. In a Singaporean adult cohort, early neutrophil mediators were assessed for their … Read more

J Leukoc Biol. 2025 May 22:qiaf072. doi: 10.1093/jleuko/qiaf072. Online ahead of print. ABSTRACT Increasing numbers of clinical cohorts have detected CCND2 mutations in acute myeloid leukemia (AML), especially in the subtype of AML with t(8;21) translocation. As known, this AML subtype is characterized by the formation of AML1-ETO fusion gene. However, AML1-ETO fusion gene alone … Read more