Journal of Leukocyte Biology

J Leukoc Biol. 2025 May 22:qiaf071. doi: 10.1093/jleuko/qiaf071. Online ahead of print. ABSTRACT Macrophages are central to innate immunity and are routinely used in vitro to examine molecular mechanisms contributing to innate immune signaling. However, there is a lack of consensus within the field for optimal in vitro culturing methods, and it is not well … Read more

J Leukoc Biol. 2025 May 7;117(5):qiaf036. doi: 10.1093/jleuko/qiaf036. ABSTRACT Excessive activation of toll-like receptor 7 and 8 (TLR7/8) plays a role in the pathogenesis of autoimmune diseases and is associated with negative outcomes from viral infections. Neutrophil activation is highly inflammatory and mediates tissue damage. We explored the effects of TLR7/8 activation in neutrophils to … Read more

J Leukoc Biol. 2025 May 21:qiaf070. doi: 10.1093/jleuko/qiaf070. Online ahead of print. ABSTRACT Psoriasis is a persistent immune-mediated inflammatory dermatosis. The treatment of psoriasis now features natural medicine as an effective new alternative because of its notable effectiveness and few side effects. Nervonic acid (NA), a long-chain fatty acid mostly sourced from the seed oils … Read more

J Leukoc Biol. 2025 May 7;117(5):qiaf046. doi: 10.1093/jleuko/qiaf046. NO ABSTRACT PMID:40391489 | DOI:10.1093/jleuko/qiaf046

J Leukoc Biol. 2025 May 20:qiaf066. doi: 10.1093/jleuko/qiaf066. Online ahead of print. ABSTRACT The immunosuppressive tumor microenvironment (TME) is a critical determinant of therapeutic resistance in colorectal cancer (CRC). The TME encompasses diverse cellular and stromal elements, including tumor cells, immune cells, extracellular matrix (ECM), and lymphatic vessels. Among these components, tumor-associated macrophages (TAMs) predominate … Read more

J Leukoc Biol. 2025 May 20:qiaf059. doi: 10.1093/jleuko/qiaf059. Online ahead of print. ABSTRACT The micro-RNA miR-125b-5p, recognized as a tumor suppressor, has demonstrated the ability to curb the proliferation of various types of cancer cells. Our latest research has revealed that miR-125b-5p also impedes the proliferation and functionality of CD4+Foxp3+ regulatory T cells (Tregs) by … Read more

J Leukoc Biol. 2025 May 19:qiaf057. doi: 10.1093/jleuko/qiaf057. Online ahead of print. ABSTRACT Optimal antimicrobial action of human neutrophils (PMN) relies on the synergy of oxidants and granule proteins, most notably that between the granule protein myeloperoxidase (MPO) and hydrogen peroxide (H2O2) to oxidize chloride anion to produce the potent microbicide, hypochlorous acid (HOCl). However, … Read more

J Leukoc Biol. 2025 May 16:qiaf068. doi: 10.1093/jleuko/qiaf068. Online ahead of print. ABSTRACT Neuromyelitis optica spectrum disorder (NMOSD) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects the optic nerves, spinal cord, and brainstem, leading to severe relapses and potentially significant neurological disability. Most NMOSD patients present with anti-aquaporin-4 … Read more

J Leukoc Biol. 2025 May 16:qiaf065. doi: 10.1093/jleuko/qiaf065. Online ahead of print. ABSTRACT Hypoxia-associated H2S accumulation promotes chemotherapy resistance in solid tumor cells. This study delved into the mechanism by which CBS/H2S signaling is involved in the development of acute myeloid leukemia (AML) resistance to cytarabine (ara-C) under hypoxic conditions. The levels of CBS and … Read more

J Leukoc Biol. 2025 May 16:qiaf063. doi: 10.1093/jleuko/qiaf063. Online ahead of print. ABSTRACT Sepsis is a life-threatening condition caused by a dysregulated immune response to infection. Neutrophils act as first line of defense against infection, but their function can become impaired in sepsis. CD300 antigen-like family member d (CD300ld), predominantly expressed on neutrophils, associates with … Read more