J Leukoc Biol. 2024 Sep 23:qiae204. doi: 10.1093/jleuko/qiae204. Online ahead of print. ABSTRACT We report on a pilot study exploring whether blood immune signatures can reveal early specific indicator profiles for patients meeting sepsis criteria upon hospital admission. We analysed samples of sepsis-suspected patients (N=20) and age-spanning healthy controls (N=12), using flow cytometry-based assays. We … Read more

J Leukoc Biol. 2024 Sep 20:qiae205. doi: 10.1093/jleuko/qiae205. Online ahead of print. ABSTRACT The cytokine interferon-gamma (IFNγ) plays a multifaceted role in intestinal immune responses ranging from anti- to pro-inflammatory depending on the setting. Here, using a 3D co-culture system based on human intestinal epithelial organoids, we explore the capacity of IFNγ-exposure to reprogram intestinal … Read more