Journal of Leukocyte Biology

J Leukoc Biol. 2025 Mar 15:qiaf031. doi: 10.1093/jleuko/qiaf031. Online ahead of print. ABSTRACT Age is an important risk factor for cardiovascular diseases (CVD) and associated with a systemic, low-grade inflammation, so called “inflammaging”. We aimed to investigate the impact of age and sex on the inflammatory markers S100A9 and components of the NLRP3 inflammasome at … Read more

J Leukoc Biol. 2025 Mar 15:qiaf033. doi: 10.1093/jleuko/qiaf033. Online ahead of print. ABSTRACT Enhancement of antibody-dependent cellular cytotoxicity (ADCC) is a promising adjunct approach to achieve HIV control in the absence of antiretroviral therapy but requires the development of potent ADCC-eliciting antibodies which can recognise diverse HIV-infected cell types. A panel of broadly neutralising antibodies … Read more

J Leukoc Biol. 2025 Mar 14:qiaf026. doi: 10.1093/jleuko/qiaf026. Online ahead of print. ABSTRACT Systemic autoinflammatory diseases (SAIDs) are rare conditions resulting from innate immune system dysregulation, culminating in repetitive bouts of systemic inflammation without the presence of external or self-antigens. Most SAIDs are associated with mutations in genes affecting the innate immune response. Tumor necrosis … Read more

J Leukoc Biol. 2025 Mar 14:qiaf029. doi: 10.1093/jleuko/qiaf029. Online ahead of print. ABSTRACT Differential diagnosis of immune-related adverse events (irAEs) or bacterial infections is sometimes very difficulty in cancer patients undergoing treatment with PD-(L)1 inhibitors. This study aimed to assess the effectiveness of the neutrophil-to-lymphocyte ratio (NLR) in distinguishing between irAEs and bacterial infections in … Read more

J Leukoc Biol. 2025 Mar 3:qiaf027. doi: 10.1093/jleuko/qiaf027. Online ahead of print. ABSTRACT Low-density neutrophils (LDNs) or polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) are involved in the pathogenesis of cancer, autoimmune and infectious diseases. They are crucial in the host-response to invading pathogens, especially during acute illness, and are associated with poor prognosis in many infectious … Read more

J Leukoc Biol. 2025 Feb 27:qiaf024. doi: 10.1093/jleuko/qiaf024. Online ahead of print. ABSTRACT Binge alcohol use is increasing among aged adults (>65 years). Alcohol-related toxicity in aged adults is associated with neurodegeneration, yet the molecular underpinnings of this age-related sensitivity to alcohol are not well described. Studies utilizing rodent models of neurodegenerative disease reveal heightened … Read more

J Leukoc Biol. 2025 Feb 26:qiaf025. doi: 10.1093/jleuko/qiaf025. Online ahead of print. ABSTRACT Polymorphonuclear leukocytes (PMNs) are terminally differentiated phagocytes with pivotal roles in infection, inflammation, tissue injury, and resolution. PMNs display a breadth of responses to diverse endogenous and exogenous stimuli, making understanding of these innate immune responders vital yet challenging to achieve. Here, … Read more

J Leukoc Biol. 2025 Feb 25:qiaf023. doi: 10.1093/jleuko/qiaf023. Online ahead of print. ABSTRACT Atopic dermatitis (AD) as well as other type 2 immune response (T2) diseases are often linked to elevated eosinophil (Eos) levels in the blood. Although the role of Eos in AD pathophysiology is suspected, it remains unclear. The development of new treatments … Read more

J Leukoc Biol. 2025 Feb 20:qiaf022. doi: 10.1093/jleuko/qiaf022. Online ahead of print. ABSTRACT Gamma delta T-cell acute lymphoblastic leukemia (γδ T-ALL) represents a rare subset of T-ALL and is correlated with high rates of induction failure, relapse and increased mortality. γδ T-ALL lacks a biologically-informed framework for guiding its classification and treatment strategies. In this … Read more

J Leukoc Biol. 2025 Feb 20:qiaf021. doi: 10.1093/jleuko/qiaf021. Online ahead of print. ABSTRACT Chronic obstructive pulmonary disease (COPD) features persistent inflammation and restricted airflow, with acute exacerbations of COPD (AECOPD) significantly worsening patient outcomes. This study aims to explore the role of Qingjin Huatan Decoction (QJHTT) on AECOPD with the syndrome of phlegm-heat obstruction of … Read more