Journal of Leukocyte Biology

J Leukoc Biol. 2026 May 6:qiag059. doi: 10.1093/jleuko/qiag059. Online ahead of print. ABSTRACT CCR1, CCR2 and CCR5 direct recruitment of monocytes and macrophages in inflammation. However, the discrete role for each receptor in monocyte/macrophage biology remains poorly understood, with previous reports citing receptor redundancy. Using transcriptomic approaches to examine inflammatory chemokine receptor expression on lung … Read more

J Leukoc Biol. 2026 May 5:qiag050. doi: 10.1093/jleuko/qiag050. Online ahead of print. ABSTRACT Despite advanced knowledge on the SARS-CoV-2-induced immunity, a deeper understanding of how virus-specific responses are assembled upon infection is necessary. Therefore, the present work investigates the MHC-restricted virus-specific responses of acute and post-acute COVID-19 patients. Our results indicate that convalescent individuals displayed … Read more

J Leukoc Biol. 2026 Apr 29:qiag017. doi: 10.1093/jleuko/qiag017. Online ahead of print. ABSTRACT Macrophage dysfunction is hallmark of atherosclerotic disease, characterized by inflammation and uptake of oxidized low-density lipoproteins (oxLDL). We investigate the role of the epigenetic reader bromodomain-containing protein 4 (BRD4) in orchestrating macrophage responses through interactions with the mechanosensitive transcriptional coactivators YAP/TAZ. Suppression … Read more

J Leukoc Biol. 2026 Apr 2;118(4):qiag037. doi: 10.1093/jleuko/qiag037. NO ABSTRACT PMID:42047575 | DOI:10.1093/jleuko/qiag037

J Leukoc Biol. 2026 Apr 21:qiag051. doi: 10.1093/jleuko/qiag051. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is a high-mortality lung disorder driven by excessive neutrophil activation. While neutrophils are central to ARDS, the metabolic pathways fueling their inflammatory response remain unclear. This study identifies CD177 as a critical regulator of neutrophil glycolysis and … Read more

J Leukoc Biol. 2026 Apr 28:qiag054. doi: 10.1093/jleuko/qiag054. Online ahead of print. ABSTRACT Skeletal muscle regeneration depends on coordinated interactions between macrophages, fibro-adipogenic progenitors (FAPs), and muscle stem cells (MuSCs). Following injury, macrophages transition from pro-inflammatory to anti-inflammatory phenotypes, regulating debris clearance, cytokine secretion, and the activity of FAPs and MuSCs. FAPs transiently support MuSC-mediated … Read more

J Leukoc Biol. 2026 Apr 25:qiag052. doi: 10.1093/jleuko/qiag052. Online ahead of print. ABSTRACT Exhausted T cells (Tex), characterized by impaired cytotoxic function, play a detrimental role in anti-tumor and anti-infection immunity but represent promising therapeutic targets for autoimmune diseases. Persistent exposure to auto-antigens drives autoreactive CD8+ or CD4+T cells toward an exhausted state, thereby mitigating … Read more

J Leukoc Biol. 2026 Apr 25:qiag053. doi: 10.1093/jleuko/qiag053. Online ahead of print. ABSTRACT HIV reservoirs persist in macrophages in people with HIV despite antiretroviral therapy, representing a barrier to cure. Factors which govern the establishment and reversal of HIV latency in different macrophage types remain poorly understood. An in vitro HIV latency model was used … Read more

J Leukoc Biol. 2026 Apr 25:qiag055. doi: 10.1093/jleuko/qiag055. Online ahead of print. ABSTRACT Eosinophils are challenging to profile by single cell RNA sequencing (scRNA-seq) approaches due to their fragile nature and the abundance of RNases and cytotoxic enzymes stored in cytoplasmic granules, which can compromise RNA integrity upon stress. Although recent technical advances have improved … Read more

J Leukoc Biol. 2026 Apr 15:qiag048. doi: 10.1093/jleuko/qiag048. Online ahead of print. ABSTRACT Neutrophils express Fc receptors on their surface to trap immune complexes. While the roles of FcγRIIa and FcγRIIIb have extensively been studied in that context, that of FcγRI remains elusive. Recently, aggregated IgGs have been shown to induce rapid FcγRI up-regulation and … Read more