Journal of Leukocyte Biology

J Leukoc Biol. 2026 Apr 9:qiag047. doi: 10.1093/jleuko/qiag047. Online ahead of print. ABSTRACT Trained innate immunity (TI) challenges the traditional view that adaptive immune cells are solely responsible for establishing immune memory. Instead, innate immune cells can develop a form of memory through persistent epigenetic, metabolic, and antimicrobial modifications, enabling them to respond to secondary … Read more

J Leukoc Biol. 2026 Apr 2;118(4):qiag040. doi: 10.1093/jleuko/qiag040. ABSTRACT Coiled-coil domain-containing proteins (CCDCs) play pivotal roles in tumorigenesis by regulating gene transcription, apoptosis, and cell cycle progression. This study focuses on the function and mechanisms of CCDC137 in acute myeloid leukemia (AML). Our findings revealed that CCDC137 is significantly overexpressed in AML and is closely … Read more

J Leukoc Biol. 2026 Apr 2;118(4):qiag027. doi: 10.1093/jleuko/qiag027. ABSTRACT The basis for differential susceptibility to Leishmania donovani infection observed in individuals remains poorly understood. Here we address this important open question comparing bone marrow-derived macrophages (BMDMs) from susceptible hamsters (hamBMDMs) and resistant mice (mBMDMs) to identify intrinsic cellular features that may contribute to host-specific outcomes. … Read more

J Leukoc Biol. 2026 Apr 1:qiag045. doi: 10.1093/jleuko/qiag045. Online ahead of print. ABSTRACT Granulomas are organized immune aggregates of myeloid and lymphoid cells that arise when the host fails to eliminate persistent stimuli; however, their function remains paradoxical, by promoting both protection from systemic dissemination while also promoting a niche for microbial survival. Traditionally defined … Read more

J Leukoc Biol. 2026 Mar 28:qiag044. doi: 10.1093/jleuko/qiag044. Online ahead of print. ABSTRACT Septic shock (SS), the most severe stage of sepsis, has a high mortality rate. Mitochondria-mediated programmed cell death (MPCD) plays a key role in SS pathogenesis, but its diagnostic value remains unclear. This study integrated the GEO public dataset and used the … Read more

J Leukoc Biol. 2026 Mar 27:qiag033. doi: 10.1093/jleuko/qiag033. Online ahead of print. ABSTRACT Neutrophils are essential leukocytes in bacterial infections, with their fate and immune regulation critically shaping disease outcomes. They eliminate pathogens through phagocytosis, degranulation, oxidative burst-mediated killing, and the release of neutrophil extracellular traps (NETs), yet these defenses can also trigger excessive inflammation … Read more

J Leukoc Biol. 2026 Mar 25:qiag042. doi: 10.1093/jleuko/qiag042. Online ahead of print. ABSTRACT Gut microbiota have been increasingly implicated in osteoarthritis (OA), but causal pathways remain unclear. Using the Gut-Immune-Joint Axis framework, we analyzed publicly available genome-wide association study (GWAS) summary statistics from one primary and two secondary datasets to evaluate genetically predicted associations between … Read more

J Leukoc Biol. 2026 Mar 25:qiag043. doi: 10.1093/jleuko/qiag043. Online ahead of print. ABSTRACT Macrophages can phagocytose tumor cells. However, tumor cells may avoid phagocytosis by activating macrophage-expressed phagocytosis checkpoints such as SIRPα, LILRB1, or Siglec-10. Here, we investigated if LNPs loaded with siRNA (siRNA-LNPs) specifically neutralizing these checkpoints may be used as a counter-regulatory approach … Read more

J Leukoc Biol. 2026 Mar 23:qiag039. doi: 10.1093/jleuko/qiag039. Online ahead of print. ABSTRACT Eosinophils are granulocytes that undergo extensive transcriptional and functional remodeling as they adapt to tissue-specific microenvironments, enabling them to perform context-dependent roles in both homeostasis and disease. The intestine, one of the most eosinophil-rich organs, exhibits profound spatial, temporal, and physiological heterogeneity … Read more

J Leukoc Biol. 2026 Mar 20:qiag041. doi: 10.1093/jleuko/qiag041. Online ahead of print. ABSTRACT Tumorigenesis and progression are driven by immune dysregulation and escape, thus evaluating immune function is crucial for the identification of diseases or health conditions. Currently, there is a lack of non-invasive biomarkers in the overall management of PCa to assess a patient’s … Read more