Journal of Leukocyte Biology

J Leukoc Biol. 2026 Jun 1:qiag071. doi: 10.1093/jleuko/qiag071. Online ahead of print. ABSTRACT Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune disorders characterized by skeletal muscle inflammation and systemic immune activation. Although traditionally viewed as T cell-driven diseases, recent evidence suggests that B lymphocytes may also contribute to disease mechanisms through both antibody-dependent … Read more

J Leukoc Biol. 2026 May 28:qiag067. doi: 10.1093/jleuko/qiag067. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder of the gut, whose pathogenesis is closely related to immune dysregulation. Regulatory T cells (Tregs), as a key cell population maintaining intestinal immune tolerance, exhibit not only reduced frequency but, more critically, … Read more

J Leukoc Biol. 2026 May 13;118(5):qiag049. doi: 10.1093/jleuko/qiag049. ABSTRACT Neutrophils are short-lived, yet critical components of the innate immune system. These cells play crucial roles in host defense and inflammation. Their high turnover during inflammatory responses is often accompanied by inflammatory lytic cell death, such as NETosis and pyroptosis, which can amplify tissue damage. Thus, … Read more

J Leukoc Biol. 2026 May 23:qiag065. doi: 10.1093/jleuko/qiag065. Online ahead of print. ABSTRACT Sarcoidosis (SRS) is a multi-organ granulomatous disorder that predominantly affects the eyes, lungs, and skin. Biopsy, the standard for a definitive SRS diagnosis, is often impractical for ocular sarcoidosis (OSRS) due to the delicate nature of the eye and risks associated with … Read more

J Leukoc Biol. 2026 May 13;118(5):qiag046. doi: 10.1093/jleuko/qiag046. ABSTRACT Macrophages are highly heterogeneous innate immune cells that populate virtually all tissues, in which they acquire distinct phenotypes and homeostatic functions shaped by their local environment. Although these cells can arise from either embryonic precursors or circulating monocytes, their ultimate identity reflects an interplay between developmentally … Read more

J Leukoc Biol. 2026 May 18:qiag064. doi: 10.1093/jleuko/qiag064. Online ahead of print. ABSTRACT Eosinophils are increasingly recognized as tissue-resident immune cells that take on diverse functions. Recent studies have shed light on the pathways that result in tissue-specific eosinophil phenotypes. In this review, we discuss the process of tissue adaptation covering the local environmental cues … Read more

J Leukoc Biol. 2026 May 14:qiag063. doi: 10.1093/jleuko/qiag063. Online ahead of print. ABSTRACT Malaria caused by Plasmodium falciparum remains a leading cause of childhood mortality in sub-Saharan Africa. The intraerythrocytic parasite can evade complement-mediated destruction through recruitment of human Factor H (FH). In vitro, Factor H-Related Protein 1 (FHR-1) competes with FH for binding sites, … Read more

J Leukoc Biol. 2026 May 14:qiag056. doi: 10.1093/jleuko/qiag056. Online ahead of print. ABSTRACT Dissemination of type 2 immunity along skin-gut-lung axes contributes to allergic march progressions in atopic individuals, yet the underlying mechanisms remain incompletely understood. In mice, gastrointestinal helminth infections can mobilize a circulating pool of gut-derived, inflammatory type 2 innate lymphoid cells (iILC2s), … Read more

J Leukoc Biol. 2026 May 13;118(5):qiag060. doi: 10.1093/jleuko/qiag060. NO ABSTRACT PMID:42124390 | DOI:10.1093/jleuko/qiag060

J Leukoc Biol. 2026 May 12:qiag058. doi: 10.1093/jleuko/qiag058. Online ahead of print. ABSTRACT Increased sensory nerve density has been described in type II inflammatory conditions and is linked to eosinophil and mast cell infiltration and neuropathic pain. To examine these relationships in eosinophilic gastrointestinal diseases (EGIDs), we developed a protocol using Clearing-enhanced 3D (Ce3D) tissue … Read more