J Leukoc Biol. 2026 Feb 28:qiag029. doi: 10.1093/jleuko/qiag029. Online ahead of print. NO ABSTRACT PMID:41761660 | DOI:10.1093/jleuko/qiag029
J Leukoc Biol. 2026 Feb 27:qiag028. doi: 10.1093/jleuko/qiag028. Online ahead of print. ABSTRACT NF-κB inducing kinase (NIK), an upstream regulator of the noncanonical NF-κB signaling pathway, is implicated in the development of Hypereosinophilic-like syndrome (HES) in mice. HES in human patients is defined by 1.5×109 cells/L circulating in the blood with end-organ infiltration and resultant … Read more
J Leukoc Biol. 2026 Feb 26:qiag026. doi: 10.1093/jleuko/qiag026. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) are a critical component of the immune response to cancer, and their role in modulating cancer progression is well-recognized. Macrophages express pattern-recognition receptors, including Class A Scavenger Receptors (SR-A), which are pivotal in regulating macrophage activation and polarization into … Read more
J Leukoc Biol. 2026 Feb 25:qiag023. doi: 10.1093/jleuko/qiag023. Online ahead of print. ABSTRACT Allergic rhinitis (AR) is a prevalent inflammatory disorder with limited therapeutic options. Ephedra sinica Stapf (ESP), a traditional Chinese herb, has shown potential in respiratory diseases, but its bioactive components and mechanisms remain unclear. This study investigates the anti-inflammatory effects of ESP-B4, … Read more
J Leukoc Biol. 2026 Feb 20:qiag024. doi: 10.1093/jleuko/qiag024. Online ahead of print. ABSTRACT Dendritic cells (DCs) function within tissues that experience wide fluctuations in oxygen availability, and these hypoxic environments exert a strong influence on innate immune activity. In this context, we identify the Hippo pathway effector YAP1 as a central regulator of human monocyte-derived … Read more
J Leukoc Biol. 2026 Feb 9;118(2):qiaf174. doi: 10.1093/jleuko/qiaf174. ABSTRACT Neutrophils are the first responders of our innate immune system, crucial for defense against various infections. The intricate regulation of neutrophil migration is essential for neutrophil function. However, a complete mechanistic understanding is missing. We previously performed a miRNA overexpression screen and identified miR-190 as a … Read more
J Leukoc Biol. 2026 Feb 9;118(2):qiag008. doi: 10.1093/jleuko/qiag008. ABSTRACT Neutrophils are key first responders to both infectious and noninfectious stress, playing a pivotal role in maintaining homeostasis through tightly regulated activation states and the release of inflammatory mediators. The Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a key regulator of inflammation and … Read more
J Leukoc Biol. 2026 Feb 9;118(2):qiag013. doi: 10.1093/jleuko/qiag013. NO ABSTRACT PMID:41662165 | DOI:10.1093/jleuko/qiag013
J Leukoc Biol. 2026 Feb 4:qiag019. doi: 10.1093/jleuko/qiag019. Online ahead of print. ABSTRACT Natural killer (NK) cell antibody-dependent cellular cytotoxicity (ADCC) contributes to effective antiviral immunity, yet the relative contribution of NK cell-intrinsic factors and antibodies in mediating these responses remain poorly understood. Here, we combined functional ADCC assays with single-cell transcriptomics of peripheral NK … Read more
J Leukoc Biol. 2026 Feb 3:qiag020. doi: 10.1093/jleuko/qiag020. Online ahead of print. ABSTRACT Despite advances in engineered adaptive immune cell therapies, current options for innate immune cell therapies are sparse. In this work, we demonstrate the utility of a neutrophil progenitor-based cell therapy. Murine conditionally-immortalized neutrophil progenitors (NPs) overcome some of the hurdles of alternative … Read more
