Journal of Leukocyte Biology

Streptococcus anginosus Activates the NLRP3 Inflammasome to Promote Inflammatory Responses from Macrophages​Anika M Arias on 8 de May de 2026 at 10:00

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J Leukoc Biol. 2026 May 8:qiag061. doi: 10.1093/jleuko/qiag061. Online ahead of print. ABSTRACT Chronic inflammation and oral dysbiosis are common features of oral squamous cell carcinoma (OSCC). The commensal streptococci, S. anginosus, is increased in oral diseases including OSCC. Our previous work revealed that S. anginosus promotes inflammatory responses from macrophage cell lines, however the … Read more

Chemokine receptor expression defines a trajectory from monocytes to mature macrophages in the lung​Heather Mathie on 5 de May de 2026 at 10:00

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J Leukoc Biol. 2026 May 6:qiag059. doi: 10.1093/jleuko/qiag059. Online ahead of print. ABSTRACT CCR1, CCR2 and CCR5 direct recruitment of monocytes and macrophages in inflammation. However, the discrete role for each receptor in monocyte/macrophage biology remains poorly understood, with previous reports citing receptor redundancy. Using transcriptomic approaches to examine inflammatory chemokine receptor expression on lung … Read more

Immune Landscape of COVID-19 recovery: Nucleocapsid as a major target of CD8+ T cell antiviral responses in convalescent HLA-A*2+ individuals from Brazil​Ágata Lopes-Ribeiro on 5 de May de 2026 at 10:00

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J Leukoc Biol. 2026 May 5:qiag050. doi: 10.1093/jleuko/qiag050. Online ahead of print. ABSTRACT Despite advanced knowledge on the SARS-CoV-2-induced immunity, a deeper understanding of how virus-specific responses are assembled upon infection is necessary. Therefore, the present work investigates the MHC-restricted virus-specific responses of acute and post-acute COVID-19 patients. Our results indicate that convalescent individuals displayed … Read more

BET inhibition curbs macrophage inflammation, lipid accumulation, and atherogenesis by disrupting the YAP/TAZ-BRD4 axis​Praveen Krishna Veerasubramanian on 29 de April de 2026 at 10:00

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J Leukoc Biol. 2026 Apr 29:qiag017. doi: 10.1093/jleuko/qiag017. Online ahead of print. ABSTRACT Macrophage dysfunction is hallmark of atherosclerotic disease, characterized by inflammation and uptake of oxidized low-density lipoproteins (oxLDL). We investigate the role of the epigenetic reader bromodomain-containing protein 4 (BRD4) in orchestrating macrophage responses through interactions with the mechanosensitive transcriptional coactivators YAP/TAZ. Suppression … Read more

CD177 Promotes NLR Inflammasome Activation in Acute Respiratory Distress Syndrome by Remodeling Neutrophil Glycolytic Metabolism​Dongfeng Shen on 28 de April de 2026 at 10:00

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J Leukoc Biol. 2026 Apr 21:qiag051. doi: 10.1093/jleuko/qiag051. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is a high-mortality lung disorder driven by excessive neutrophil activation. While neutrophils are central to ARDS, the metabolic pathways fueling their inflammatory response remain unclear. This study identifies CD177 as a critical regulator of neutrophil glycolysis and … Read more

Macrophage and fibro-adipogenic progenitor (FAP) communication in skeletal muscle regeneration: Tissue homeostasis and pathogenic remodeling​Seily Shrestha on 28 de April de 2026 at 10:00

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J Leukoc Biol. 2026 Apr 28:qiag054. doi: 10.1093/jleuko/qiag054. Online ahead of print. ABSTRACT Skeletal muscle regeneration depends on coordinated interactions between macrophages, fibro-adipogenic progenitors (FAPs), and muscle stem cells (MuSCs). Following injury, macrophages transition from pro-inflammatory to anti-inflammatory phenotypes, regulating debris clearance, cytokine secretion, and the activity of FAPs and MuSCs. FAPs transiently support MuSC-mediated … Read more

T cell exhaustion: Next-generation target of autoimmune diseases?​Yuzhen Ouyang on 26 de April de 2026 at 10:00

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J Leukoc Biol. 2026 Apr 25:qiag052. doi: 10.1093/jleuko/qiag052. Online ahead of print. ABSTRACT Exhausted T cells (Tex), characterized by impaired cytotoxic function, play a detrimental role in anti-tumor and anti-infection immunity but represent promising therapeutic targets for autoimmune diseases. Persistent exposure to auto-antigens drives autoreactive CD8+ or CD4+T cells toward an exhausted state, thereby mitigating … Read more

Macrophage heterogeneity influences cellular response to HIV infection and latency modulation​Michelle E Wong on 25 de April de 2026 at 10:00

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J Leukoc Biol. 2026 Apr 25:qiag053. doi: 10.1093/jleuko/qiag053. Online ahead of print. ABSTRACT HIV reservoirs persist in macrophages in people with HIV despite antiretroviral therapy, representing a barrier to cure. Factors which govern the establishment and reversal of HIV latency in different macrophage types remain poorly understood. An in vitro HIV latency model was used … Read more

Guidelines for single cell RNA sequencing analysis of eosinophils​Kristina Handler on 25 de April de 2026 at 10:00

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J Leukoc Biol. 2026 Apr 25:qiag055. doi: 10.1093/jleuko/qiag055. Online ahead of print. ABSTRACT Eosinophils are challenging to profile by single cell RNA sequencing (scRNA-seq) approaches due to their fragile nature and the abundance of RNases and cytotoxic enzymes stored in cytoplasmic granules, which can compromise RNA integrity upon stress. Although recent technical advances have improved … Read more

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