Mucosal Immunology

Mucosal Immunol. 2026 Jul 8:100378. doi: 10.1016/j.mucimm.2026.100378. Online ahead of print. ABSTRACT Integrin α4β7 directs lymphocyte trafficking to the intestinal lamina propria (LP) and is a major therapeutic target in inflammatory bowel disease (IBD). Although integrin (Itg) β7 has been extensively studied in T-cell recruitment, its role in protective mucosal humoral immunity during chronic ileitis … Read more

Mucosal Immunol. 2026 Jul 7:100380. doi: 10.1016/j.mucimm.2026.100380. Online ahead of print. ABSTRACT Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that predominantly acts on myeloid cells. Although decades of research have revealed diverse functions of GM-CSF during inflammation across tissues, it exerts important homeostatic functions, most notably in the lung. Extensive studies have established the essential … Read more

Mucosal Immunol. 2026 Jul 7:100379. doi: 10.1016/j.mucimm.2026.100379. Online ahead of print. ABSTRACT Cystic fibrosis (CF) is caused by mutations in the CFTR gene resulting in alterations in the immune functions of the airway epithelium, including reduced biosynthesis of the specialized pro-resolving lipid mediators (SPMs). Aspergillus fumigatus is the most isolated filamentous fungus in patients with … Read more

Mucosal Immunol. 2026 Jul 5:100376. doi: 10.1016/j.mucimm.2026.100376. Online ahead of print. ABSTRACT A central challenge faced by the immune system is not simply detecting microbes but determining how to respond to them. In the intestine, where commensals and pathogens coexist, this decision is neither binary nor dictated by a single receptor. Instead, it emerges from … Read more

Mucosal Immunol. 2026 Jul 4:100377. doi: 10.1016/j.mucimm.2026.100377. Online ahead of print. ABSTRACT Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system associated with alterations in gut commensals, including Akkermansia muciniphila (A. muciniphila). However, its role in MS remains unclear. Here, we report elevated serum lipopolysaccharide (LPS) and anti-LPS IgG levels in patients … Read more

Mucosal Immunol. 2026 Jul 2:100375. doi: 10.1016/j.mucimm.2026.100375. Online ahead of print. ABSTRACT Cataloging the gut microbiome and understanding its interactions and association with the host immune system remains relevant to identify potential treatments for complex chronic diseases, including cancer. Studying the gut microbiome is more accessible than ever, thanks to the dramatic cost reduction of … Read more

Mucosal Immunol. 2026 Jul 2:100372. doi: 10.1016/j.mucimm.2026.100372. Online ahead of print. ABSTRACT The intestine is a multifunctional tissue relying on multipotent stem cells to establish a repertoire of epithelial cell lineages. We have previously shown that the enteric parasitic nematode Heligmosomoides polygyrus bakeri (Hpb) directly regulates the intestinal stem cell compartment, tuning the epithelium to … Read more

Mucosal Immunol. 2026 Jul 1:100374. doi: 10.1016/j.mucimm.2026.100374. Online ahead of print. ABSTRACT Seasonal epidemics and the persistent threat of a pandemic provide a strong impetus to understand mechanisms of protection against influenza infection. T cell intrinsic signaling through the TNFR superfamily member 4-1BB is critical for the accumulation of antigen-specific CD8+ effector and memory T … Read more

Mucosal Immunol. 2026 Jun 30:100373. doi: 10.1016/j.mucimm.2026.100373. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease affects approximately 7 million individuals worldwide. Its pathogenesis involves genetic susceptibility, alterations in the gut microbiota, and immune system imbalance, with both innate and adaptive components contributing through aberrant cytokine signaling. The … Read more

Mucosal Immunol. 2026 Jun 27:100371. doi: 10.1016/j.mucimm.2026.100371. Online ahead of print. ABSTRACT Postbiotics offer improved safety and stability over live probiotics for modulating intestinal immunity, yet the receptor-mediated mechanisms underlying mucosal tolerance remain unclear. Nucleotide-binding oligomerization domain 2 (NOD2), a cytosolic sensor of bacterial cell wall components and a major genetic risk factor for inflammatory … Read more