Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice. Julie Drieu La Rochelle

Mucosal Immunol. 2024 Sep 7:S1933-0219(24)00093-X. doi: 10.1016/j.mucimm.2024.08.012. Online ahead of print. ABSTRACT Inflammation of the ileum, or ileitis, is commonly caused by Crohn’s disease (CD) but can also accompany ulcerative colitis (backwash ileitis), infections or drug-related damage. Oxidative tissue injury triggered by reactive oxygen species (ROS) is considered part of the ileitis etiology. However, not … Read more

Dysregulated myeloid differentiation in colitis is induced by inflammatory osteoclasts in a TNFα-dependent manner. Maria-Bernadette Madel

Mucosal Immunol. 2024 Sep 25:S1933-0219(24)00098-9. doi: 10.1016/j.mucimm.2024.09.005. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) is characterized by very severe intestinal inflammation associated with extra-intestinal manifestations. One of the most critical ones is bone destruction, which remains a major cause of morbidity and a risk factor for osteopenia and osteoporosis in IBD patients. In … Read more

Epithelial dysfunction is prevented by IL-22 treatment in a <i>Citrobacter rodentium</i>-induced colitis model that shares similarities with inflammatory bowel disease

Mucosal Immunology, Published online: 13 November 2022; doi:10.1038/s41385-022-00577-wEpithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with inflammatory bo…

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