Mucosal Immunology

Diet-Induced dyslipidemia enhances IFN- γ production in mycolic Acid-Specific T cells and affects mycobacterial control. Yen-Lin Lin

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Mucosal Immunol. 2025 May 3:S1933-0219(25)00047-9. doi: 10.1016/j.mucimm.2025.04.009. Online ahead of print. ABSTRACT Dyslipidemia, characterized by altered lipid profiles, influences host immune responses against infections, including Mycobacterium tuberculosis (Mtb). While the effects of dyslipidemia on conventional T cell responses are well documented, its impact on group 1-CD1 restricted T cells, a distinct subset of lipid antigen-specific … Read more

Anti-ST2 antibody reduces airway hyperresponsiveness mediated by monocyte-derived macrophages during influenza A infection. Rohin Chakraborty

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Mucosal Immunol. 2025 May 2:S1933-0219(25)00046-7. doi: 10.1016/j.mucimm.2025.04.008. Online ahead of print. ABSTRACT Influenza A virus (IAV) infections trigger asthma attacks and cause airway hyperresponsiveness (AHR) in murine models. However, the mechanism by which AHR is induced remains to be fully elucidated. Here, we show that targeting the interleukin (IL)-33 suppression of tumorigenicity 2 (ST2) receptor … Read more

Spatial single-cell analysis identifies placental villi structuraland immune remodeling across gestation. Suganthinie Velagala

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Mucosal Immunol. 2025 Apr 25:S1933-0219(25)00043-1. doi: 10.1016/j.mucimm.2025.04.005. Online ahead of print. ABSTRACT Pregnancies rely upon the balance between fetal and maternal immune systems. Employing imaging mass cytometry, this study creates a spatial map landscape to unravel the cellular dynamics within the placental villi (PV). Consistent with previous data we report structural remodeling in PV, highlighted … Read more

RSV infection in neonatal mice and gastrointestinal microbiome alteration contribute to allergic predisposition. Alexander D Ethridge

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Mucosal Immunol. 2025 Apr 23:S1933-0219(25)00045-5. doi: 10.1016/j.mucimm.2025.04.007. Online ahead of print. ABSTRACT Severe respiratory syncytial virus (RSV) infection during infancy is associated with a 2 to 4-fold increased risk for the development of wheezing and asthma. Recent studies have implicated microbiome changes, either within the lung or gut, during early life can also affect the … Read more

PAD4 inhibition impacts immune responses in SARS-CoV-2 infection. Caio Santos Bonilha

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Mucosal Immunol. 2025 Apr 19:S1933-0219(25)00044-3. doi: 10.1016/j.mucimm.2025.04.006. Online ahead of print. ABSTRACT Protein arginine deiminase 4 (PAD4) has emerged as a potential therapeutic target for various diseases due to its role in promoting neutrophil extracellular trap (NET) formation. NETs, composed of DNA and antimicrobial proteins, serve as a defense mechanism against pathogens but can also … Read more

A zebrafish model of intestinal epithelial damage reveals macrophages and igfbp1a as major modulators of mucosal healing. Rodrigo A Morales Castro

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Mucosal Immunol. 2025 Apr 17:S1933-0219(25)00042-X. doi: 10.1016/j.mucimm.2025.04.004. Online ahead of print. ABSTRACT Promoting intestinal regeneration and enhancing mucosal healing have emerged as promising therapeutic alternatives for treating intestinal disorders that compromise epithelial barrier integrity and function. However, the cellular and molecular mechanisms underlying these processes remain poorly understood. This knowledge gap is partly due to … Read more

Living on the edge: Mucus-associated microbes in the colon. Mihovil Joja

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Mucosal Immunol. 2025 Apr 13:S1933-0219(25)00041-8. doi: 10.1016/j.mucimm.2025.04.003. Online ahead of print. ABSTRACT The colonic mucus layer acts as a physicochemical barrier to pathogen invasion and as a habitat for mucus-associated microbes. This mucosal microbiome plays a crucial role in moderating mucus production, maintaining barrier integrity, and shaping the host immune response. However, unchecked mucin foraging … Read more

A multi-omics microbiome signature is associated with the benefits of gastric bypass surgery and is differentiated from diet induced weight loss through 2 years of follow-up. Vancheswaran Gopalakrishnan

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Mucosal Immunol. 2025 Apr 11:S1933-0219(25)00040-6. doi: 10.1016/j.mucimm.2025.04.002. Online ahead of print. ABSTRACT Roux-en-Y gastric bypass (GBP) surgery is an effective treatment for reducing body weight and correcting metabolic dysfunction in individuals with severe obesity. Herein, we characterize the differences between very low energy diet (VLED) and GBP induced weight loss by multi-omic analyses of microbiome … Read more

Innate immunity of the lungs in homeostasis and disease. Peter A A Norris

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Mucosal Immunol. 2025 Apr 10:S1933-0219(25)00039-X. doi: 10.1016/j.mucimm.2025.04.001. Online ahead of print. ABSTRACT Humans breathe thousands of litres of non-sterile air each day containing bacteria, viruses, and fungi, as well as pollutants, allergens, and other particles. The continual exposure to foreign particles is juxtaposed with the vast surface area of the blood-air-barrier which becomes extremely thin … Read more

Hypertonic intranasal vaccines gain nasal epithelia access to exert strong immunogenicity. Soichiro Hashimoto

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Mucosal Immunol. 2025 Apr 1:S1933-0219(25)00032-7. doi: 10.1016/j.mucimm.2025.03.006. Online ahead of print. ABSTRACT Intranasal vaccines potentially offer superior protection against viral infections compared with injectable vaccines. The immunogenicity of intranasal vaccines including adenovirus vector (AdV), has room for improvement, while few options are available for safe execution. In this study, we demonstrate that modifying a basic … Read more

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