Mucosal Immunology

Microbial remodeling of gut tryptophan metabolism and indole-3-lactate production regulate epithelial barrier repair and viral suppression in human and simian immunodeficiency virus infections. Clarissa Santos Rocha

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Mucosal Immunol. 2025 Jan 31:S1933-0219(25)00011-X. doi: 10.1016/j.mucimm.2025.01.011. Online ahead of print. ABSTRACT Gut inflammatory diseases cause microbial dysbiosis. Human immunodeficiency virus-1 (HIV) infection disrupts intestinal integrity, subverts repair/renewal pathways, impairs mucosal immunity and propels microbial dysbiosis. However, microbial metabolic mechanisms driving repair mechanisms in virally inflamed gut are not well understood. We investigated the capability … Read more

Damage sensing through TLR9 regulates inflammatory and antiviral responses during influenza infection. Jooyoung Kim

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Mucosal Immunol. 2025 Jan 28:S1933-0219(25)00008-X. doi: 10.1016/j.mucimm.2025.01.008. Online ahead of print. ABSTRACT Host response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses through pattern recognition receptors. How the … Read more

Maternal obesity associates with altered humoral immunity in blood and colostrum. Erick S Sánchez-Salguero

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Mucosal Immunol. 2025 Jan 25:S1933-0219(25)00007-8. doi: 10.1016/j.mucimm.2025.01.007. Online ahead of print. ABSTRACT Maternal obesity is a condition with increasing prevalence worldwide, that correlates with negative infant outcomes. Here we performed an observational cross-sectional study, where peripheral blood and colostrum samples from 37 mothers with BMI between 18.5-25 or > 30 kg/m2 (21 and 16 mothers, … Read more

Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age. Julia A Brown

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Mucosal Immunol. 2025 Jan 23:S1933-0219(25)00006-6. doi: 10.1016/j.mucimm.2025.01.006. Online ahead of print. ABSTRACT Our immune system and gut microbiota are intricately coupled from birth, both going through maturation during early life and senescence during aging almost in a synchronized fashion. The symbiotic relationship between the human host and microbiota is critically dependent on a healthy immune … Read more

TIFA renders intestinal epithelial cells responsive to microbial ADP-heptose and drives colonic inflammation in mice. Lena Erkert

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Mucosal Immunol. 2025 Jan 20:S1933-0219(25)00003-0. doi: 10.1016/j.mucimm.2025.01.003. Online ahead of print. ABSTRACT Intestinal immune homeostasis relies on intestinal epithelial cells (IECs), which provide an efficient barrier, and warrant a state of tolerance between the microbiome and the mucosal immune system. Thus, proper epithelial microbial sensing and handling of microbes is key to preventing excessive immunity, … Read more

Breast milk delivery of an engineered dimeric IgA protects neonates against rotavirus. Stephanie N Langel

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Mucosal Immunol. 2025 Jan 20:S1933-0219(25)00002-9. doi: 10.1016/j.mucimm.2025.01.002. Online ahead of print. ABSTRACT Dimeric IgA (dIgA) is the dominant antibody in many mucosal tissues. It is actively transported onto mucosal surfaces as secretory IgA (sIgA) which plays an integral role in protection against enteric pathogens, particularly in young children. Therapeutic strategies that deliver engineered, potently neutralizing … Read more

Sialidase fusion protein protects against influenza infection in a cigarette smoke-induced model of COPD. Cheng-Yen Chang

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Mucosal Immunol. 2025 Jan 19:S1933-0219(25)00004-2. doi: 10.1016/j.mucimm.2025.01.004. Online ahead of print. ABSTRACT First- and secondhand smokers are at an increased risk for influenza virus (IFV)-related respiratory failure and death. Despite approved influenza antiviral treatments, there is an unmet need for treatments that can improve outcomes in populations at risk for respiratory failure, including tobacco users … Read more

T follicular helper cell expansion and hyperimmunoglobulinemia with spontaneous IgE production to dietary antigens in IgA-deficient mice. Yasmeen S El Ansari

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Mucosal Immunol. 2025 Jan 15:S1933-0219(25)00005-4. doi: 10.1016/j.mucimm.2025.01.005. Online ahead of print. ABSTRACT Immunoglobulin A (IgA), the most abundantly produced antibody at mucosal surfaces, is thought to play key roles in immune responses to respiratory and enteric pathogens and in the regulation of commensal colonization. Low IgA levels have been associated with recurrent infections and immune … Read more

Immune crosstalk between respiratory and intestinal mucosal tissues in respiratory infections. Min Zhao

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Mucosal Immunol. 2025 Jan 2:S1933-0219(24)00136-3. doi: 10.1016/j.mucimm.2024.12.013. Online ahead of print. ABSTRACT Mucosal tissues, including those in the respiratory and gastrointestinal tracts, are critical barrier surfaces for pathogen invasion. Infections at these sites not only trigger local immune response, but also recruit immune cells from other tissues. Emerging evidence in mouse models and human samples … Read more

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