Mucosal Immunology

Mucosal Immunol. 2025 Feb 25:S1933-0219(25)00025-X. doi: 10.1016/j.mucimm.2025.02.007. Online ahead of print. ABSTRACT Autoimmune uveitis (AIU) is an immune-inflammatory disease that can lead to blindness. However, incomplete understanding of the involved immune cell subsets and their contributions to retinal injury has hindered the development of effective AIU therapies. Using single-cell RNA sequencing and immunofluorescence, we identified … Read more

Mucosal Immunol. 2025 Feb 21:S1933-0219(25)00021-2. doi: 10.1016/j.mucimm.2025.02.003. Online ahead of print. ABSTRACT Emerging evidence indicates that gingival-resident helper CD4+ T cells are major drivers of periodontal inflammation in response to commensal and pathogenic oral microorganisms. Whether tissue-resident memory CD8+ T cells (TRM), which principally safeguard against viruses and cancer but also drive certain autoimmune and … Read more

Mucosal Immunol. 2025 Feb 21:S1933-0219(25)00023-6. doi: 10.1016/j.mucimm.2025.02.005. Online ahead of print. ABSTRACT Interleukin-10 (IL-10) is an immunomodulatory cytokine critical for intestinal immune homeostasis. IL-10 is produced by various immune cells but IL-10 receptor signaling in intestinal CX3CR1+ mononuclear phagocytes is necessary to prevent spontaneous colitis in mice. Here, we utilized fluorescent protein reporters and cell-specific … Read more

Mucosal Immunol. 2025 Feb 19:S1933-0219(25)00022-4. doi: 10.1016/j.mucimm.2025.02.004. Online ahead of print. ABSTRACT Lung-resident memory T cells (lung TRMs) settle in the lung and respond rapidly to external antigens, and are therefore considered to have great potential for development of respiratory vaccines. Here, we demonstrate that lung-resident memory Th2 cells (lung TRM2) protect against pulmonary mycosis … Read more

Mucosal Immunol. 2025 Feb 19:S1933-0219(25)00020-0. doi: 10.1016/j.mucimm.2025.02.002. Online ahead of print. ABSTRACT Recently, we demonstrated that influenza A virus (IAV)-infected murine neonates lacking a functional IFN-I receptor (IFNAR-/-) had significantly improved survival and reduced lung pathology relative to wild-type (WT) neonates. In direct contrast, adult IFNAR-/- mice display enhanced morbidity following IAV infection relative to … Read more

Mucosal Immunol. 2025 Feb 18:S1933-0219(25)00019-4. doi: 10.1016/j.mucimm.2025.02.001. Online ahead of print. ABSTRACT Influenza virus infection is a leading cause of morbidity and mortality worldwide, posing a significant public health problem. The pro-inflammatory cytokine interleukin-6 (IL-6) has been shown to promote defense against respiratory viral infection, while excessive IL-6 responses have been associated with severe pneumonia. … Read more

Mucosal Immunol. 2025 Feb 5:S1933-0219(25)00010-8. doi: 10.1016/j.mucimm.2025.01.010. Online ahead of print. ABSTRACT The ocular surface microbiota plays a critical role in maintaining corneal homeostasis, but its disruption and subsequent effects on corneal functions remain poorly understood. This study investigates how antibiotic-induced microbial depletion affects the corneal circadian transcriptome in C57BL/6J mice. Dysbiosis was induced using … Read more

Mucosal Immunol. 2025 Feb 5:S1933-0219(25)00013-3. doi: 10.1016/j.mucimm.2025.01.013. Online ahead of print. ABSTRACT Mitochondria are key regulators of inflammatory responses and mitochondrial dysfunction is closely linked to various inflammatory diseases. Increasing genetic and experimental evidence suggests that mitochondria play a critical role in inflammatory bowel disease (IBD). In the complex environment of the intestinal tract, intestinal … Read more

Mucosal Immunol. 2025 Feb 1:S1933-0219(25)00012-1. doi: 10.1016/j.mucimm.2025.01.012. Online ahead of print. ABSTRACT Innate lymphoid cells (ILC) have emerged as critical immune effectors with key roles in orchestrating the wider immune response. While ILC are relatively rare cells they are found enriched within discrete microenvironments, predominantly within barrier tissues. An emerging body of evidence implicates complex … Read more

Mucosal Immunol. 2025 Feb 1:S1933-0219(25)00009-1. doi: 10.1016/j.mucimm.2025.01.009. Online ahead of print. ABSTRACT The ocular mucosal surface regularly encounters external materials in the air and tear fluids. Microfold (M) cells, specialized epithelial cells for antigen uptake, are present in tear duct-associated lymphoid tissue (TALT) within the nasolacrimal sac; however, their immunological significance is unclear. We generated … Read more