Mucosal Immunology

Mucosal Immunol. 2025 Jan 25:S1933-0219(25)00007-8. doi: 10.1016/j.mucimm.2025.01.007. Online ahead of print. ABSTRACT Maternal obesity is a condition with increasing prevalence worldwide, that correlates with negative infant outcomes. Here we performed an observational cross-sectional study, where peripheral blood and colostrum samples from 37 mothers with BMI between 18.5-25 or > 30 kg/m2 (21 and 16 mothers, … Read more

Mucosal Immunol. 2025 Jan 23:S1933-0219(25)00006-6. doi: 10.1016/j.mucimm.2025.01.006. Online ahead of print. ABSTRACT Our immune system and gut microbiota are intricately coupled from birth, both going through maturation during early life and senescence during aging almost in a synchronized fashion. The symbiotic relationship between the human host and microbiota is critically dependent on a healthy immune … Read more

Mucosal Immunol. 2025 Jan 21:S1933-0219(25)00001-7. doi: 10.1016/j.mucimm.2025.01.001. Online ahead of print. NO ABSTRACT PMID:39843282 | DOI:10.1016/j.mucimm.2025.01.001

Mucosal Immunol. 2025 Jan 20:S1933-0219(25)00003-0. doi: 10.1016/j.mucimm.2025.01.003. Online ahead of print. ABSTRACT Intestinal immune homeostasis relies on intestinal epithelial cells (IECs), which provide an efficient barrier, and warrant a state of tolerance between the microbiome and the mucosal immune system. Thus, proper epithelial microbial sensing and handling of microbes is key to preventing excessive immunity, … Read more

Mucosal Immunol. 2025 Jan 20:S1933-0219(25)00002-9. doi: 10.1016/j.mucimm.2025.01.002. Online ahead of print. ABSTRACT Dimeric IgA (dIgA) is the dominant antibody in many mucosal tissues. It is actively transported onto mucosal surfaces as secretory IgA (sIgA) which plays an integral role in protection against enteric pathogens, particularly in young children. Therapeutic strategies that deliver engineered, potently neutralizing … Read more

Mucosal Immunol. 2025 Jan 19:S1933-0219(25)00004-2. doi: 10.1016/j.mucimm.2025.01.004. Online ahead of print. ABSTRACT First- and secondhand smokers are at an increased risk for influenza virus (IFV)-related respiratory failure and death. Despite approved influenza antiviral treatments, there is an unmet need for treatments that can improve outcomes in populations at risk for respiratory failure, including tobacco users … Read more

Mucosal Immunol. 2025 Jan 15:S1933-0219(25)00005-4. doi: 10.1016/j.mucimm.2025.01.005. Online ahead of print. ABSTRACT Immunoglobulin A (IgA), the most abundantly produced antibody at mucosal surfaces, is thought to play key roles in immune responses to respiratory and enteric pathogens and in the regulation of commensal colonization. Low IgA levels have been associated with recurrent infections and immune … Read more

Mucosal Immunol. 2025 Jan 2:S1933-0219(24)00136-3. doi: 10.1016/j.mucimm.2024.12.013. Online ahead of print. ABSTRACT Mucosal tissues, including those in the respiratory and gastrointestinal tracts, are critical barrier surfaces for pathogen invasion. Infections at these sites not only trigger local immune response, but also recruit immune cells from other tissues. Emerging evidence in mouse models and human samples … Read more

Mucosal Immunol. 2024 Dec 31:S1933-0219(24)00137-5. doi: 10.1016/j.mucimm.2024.12.014. Online ahead of print. ABSTRACT Inflammatory bowel diseases (IBDs) are characterized by unrestrained innate and adaptive immune responses and compromised intestinal epithelial barrier integrity. Regulatory T (Treg) cells are crucial for maintaining self-tolerance and immune homeostasis in intestinal tissues. Prostaglandin E2 (PGE2), a bioactive lipid compound derived from … Read more

Mucosal Immunol. 2024 Dec 31:S1933-0219(24)00138-7. doi: 10.1016/j.mucimm.2024.12.015. Online ahead of print. ABSTRACT Diabetes mellitus is associated with an increased risk of pneumonia, often caused by so-called typical and atypical pathogens including Streptoccocus pneumoniae and Legionella pneumophila, respectively. Here, we employed a variety of mouse models to investigate how diabetes influences pulmonary antibacterial immunity. Following intranasal … Read more