Mucosal Immunology

Targeting the EP2 receptor ameliorates inflammatory bowel disease in mice by enhancing the immunosuppressive activity of Treg cells. Chenchen Wang

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Mucosal Immunol. 2024 Dec 31:S1933-0219(24)00137-5. doi: 10.1016/j.mucimm.2024.12.014. Online ahead of print. ABSTRACT Inflammatory bowel diseases (IBDs) are characterized by unrestrained innate and adaptive immune responses and compromised intestinal epithelial barrier integrity. Regulatory T (Treg) cells are crucial for maintaining self-tolerance and immune homeostasis in intestinal tissues. Prostaglandin E2 (PGE2), a bioactive lipid compound derived from … Read more

Diabetes impairs IFNγ-dependent antibacterial defense in the lungs. Facundo Fiocca Vernengo

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Mucosal Immunol. 2024 Dec 31:S1933-0219(24)00138-7. doi: 10.1016/j.mucimm.2024.12.015. Online ahead of print. ABSTRACT Diabetes mellitus is associated with an increased risk of pneumonia, often caused by so-called typical and atypical pathogens including Streptoccocus pneumoniae and Legionella pneumophila, respectively. Here, we employed a variety of mouse models to investigate how diabetes influences pulmonary antibacterial immunity. Following intranasal … Read more

Glial-immune interactions in barrier organs. Julia Karjalainen

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Mucosal Immunol. 2024 Dec 21:S1933-0219(24)00135-1. doi: 10.1016/j.mucimm.2024.12.012. Online ahead of print. ABSTRACT Neuro-immune interactions within barrier organs, such as lung, gut, and skin, are crucial in regulating tissue homeostasis, inflammatory responses, and host defence. Our rapidly advancing understanding of peripheral neuroimmunology is transforming the field of barrier tissue immunology, offering a fresh perspective for developing … Read more

Neutrophil NADPH oxidase promotes bacterial eradication and regulates NF-κB-Mediated inflammation via NRF2 signaling during urinary tract infections. Israel Cotzomi-Ortega

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Mucosal Immunol. 2024 Dec 20:S1933-0219(24)00133-8. doi: 10.1016/j.mucimm.2024.12.010. Online ahead of print. ABSTRACT The precise role of neutrophil-derived reactive oxygen species (ROS) in combating bacterial uropathogens during urinary tract infections (UTI) remains largely unexplored. In this study, we elucidate the antimicrobial significance of NADPH oxidase 2 (NOX2)-derived ROS, as opposed to mitochondrial ROS, in facilitating neutrophil-mediated … Read more

Tissue-resident natural killer cells derived from conventional natural killer cells are regulated by progesterone in the uterus. Bruna K Tatematsu

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Mucosal Immunol. 2024 Dec 19:S1933-0219(24)00132-6. doi: 10.1016/j.mucimm.2024.12.009. Online ahead of print. ABSTRACT The murine uterus contains three subsets of innate lymphoid cells (ILCs). Innate lymphoid cell type 1 (ILC1) and conventional natural killer (cNK) cells seed the uterus before puberty. Tissue-resident NK (trNK) cells emerge at puberty and vary in number during the estrous cycle. … Read more

Decidualization-associated recruitment of cytotoxic memory CD8+T cells to the maternal-fetal interface for immune defense. Xixi Huang

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Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00130-2. doi: 10.1016/j.mucimm.2024.12.007. Online ahead of print. ABSTRACT Decidual CD8+T (dCD8+T) cells are pivotal in the maintenance of the delicate balance between immune tolerance towards the fetus and immune resistance against pathogens. The endometrium and decidua represent uterine environments before and during pregnancy, respectively, and the composition and phenotypic alterations of … Read more

Impact of smoking on gut microbiota and short-chain fatty acids in human and mice: Implications for COPD. Shiro Otake

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Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00129-6. doi: 10.1016/j.mucimm.2024.12.006. Online ahead of print. ABSTRACT We aimed to elucidate the dynamic changes in short-chain fatty acids (SCFA) produced by the gut microbiota following smoking exposure and their role in chronic obstructive pulmonary disease (COPD) pathogenesis. SCFA concentrations were measured in human plasma, comparing non-smokers (n = 6) and … Read more

Highly multiplexed cytokine analysis of bronchoalveolar lavage and plasma reveals age-related dynamics and correlates of inflammation in children. Shivanthan Shanthikumar

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Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00131-4. doi: 10.1016/j.mucimm.2024.12.008. Online ahead of print. ABSTRACT Despite the central role of cytokines in mediating inflammation that underlies a range of childhood diseases, cytokine testing remains primarily limited to research settings and surrogate markers of inflammation are often used to inform clinical diagnostic and treatment decisions. There are currently no … Read more

How the early life microbiome shapes immune programming in childhood asthma and allergies. Courtney Hoskinson

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Mucosal Immunol. 2024 Dec 13:S1933-0219(24)00128-4. doi: 10.1016/j.mucimm.2024.12.005. Online ahead of print. ABSTRACT Despite advances in our understanding of their diagnosis and treatment, pediatric allergies impose substantial burdens on affected children, families, and healthcare systems. Further, the prevalence of allergic diseases has dramatically increased over the past half-century, leading to additional concerns and concerted efforts to … Read more

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