Mucosal Immunology

Mucosal Immunol. 2024 Nov 21:S1933-0219(24)00112-0. doi: 10.1016/j.mucimm.2024.11.004. Online ahead of print. ABSTRACT The fungal community of the skin microbiome is dominated by a single genus, Malassezia. Besides its symbiotic lifestyle at the host interface, this commensal yeast has also been associated with diverse inflammatory skin diseases in humans and pet animals. Stable colonization is maintained … Read more

Mucosal Immunol. 2024 Nov 8:S1933-0219(24)00110-7. doi: 10.1016/j.mucimm.2024.11.002. Online ahead of print. ABSTRACT There is an unmet need for effectively treating dry eye disease (DED), a T cell-mediated chronic, inflammatory ocular surface disorder. Given the potential of nonneuronal adrenergic system in modulating T cell response, we herein investigated the therapeutic efficacy and the underlying mechanisms of … Read more

Mucosal Immunol. 2024 Nov 7:S1933-0219(24)00109-0. doi: 10.1016/j.mucimm.2024.11.001. Online ahead of print. ABSTRACT Altered intestinal immune homeostasis leads to chronic inflammation in Crohn’s disease (CD). To address disease- and tissue-specific alterations, we performed a T cell-centric mass cytometry analysis of peripheral and intestinal lymphocytes from patients with CD and healthy donors’ PBMCs. Chronic intestinal inflammation enforced … Read more

Mucosal Immunol. 2023 Oct 27:S1933-0219(23)00081-8. doi: 10.1016/j.mucimm.2023.10.003. Online ahead of print. NO ABSTRACT PMID:39491094 | DOI:10.1016/j.mucimm.2023.10.003

Mucosal Immunol. 2023 Oct 27:S1933-0219(23)00082-X. doi: 10.1016/j.mucimm.2023.10.004. Online ahead of print. ABSTRACT Endogenous retroelements play vital roles in sustaining immune homeostasis. Activation of endogenous retroelements can trigger cGAS/STING pathway and downstream pro-inflammatory cytokine production. M1 macrophages, which can be induced by pro-inflammatory cytokines, are involved in the development of colitis. Here we aimed to determine … Read more

Mucosal Immunol. 2024 Oct 17:S1933-0219(24)00105-3. doi: 10.1016/j.mucimm.2024.10.002. Online ahead of print. ABSTRACT The lungs represent a dynamic microenvironment where airway macrophages (AMs) are the major lung-resident macrophages. AMs dictate the balance between tissue homeostasis and immune activation and thus have contradictory functions by maintaining tolerance and tissue homeostasis, as well as initiating strong inflammatory responses. … Read more

Mucosal Immunol. 2024 Oct 14:S1933-0219(24)00108-9. doi: 10.1016/j.mucimm.2024.10.005. Online ahead of print. ABSTRACT To establish protection against harmful foreign antigens, the small intestine harbors guardian sites called Peyer’s patches (PPs). PPs take up antigens through microfold (M) cells and transfer them to the sub-epithelial dome (SED), which contains a high density of mononuclear phagocytes (MPs), for … Read more

Mucosal Immunol. 2024 Oct 11:S1933-0219(24)00107-7. doi: 10.1016/j.mucimm.2024.10.004. Online ahead of print. ABSTRACT Infections by enteric virus and intestinal inflammation are recognized as a leading cause of deadly gastroenteritis, and NLRP6 and NLRP9b signaling control these infection and inflammation. However, the regulatory mechanisms of the NLRP6 and NLRP9b signaling in enteric viral infection remain unexplored. In … Read more

Mucosal Immunol. 2024 Oct 8:S1933-0219(24)00106-5. doi: 10.1016/j.mucimm.2024.10.003. Online ahead of print. ABSTRACT While much is known about the functional effects of type 2 cytokines interleukin (IL)-4, IL-5 and IL-13 in homeostasis and disease, we still poorly understand the functions of IL-9. Chronic inflammation seen in allergic diseases, autoimmunity and cancer is however frequently accompanied by … Read more

Mucosal Immunol. 2024 Oct 5:S1933-0219(24)00104-1. doi: 10.1016/j.mucimm.2024.10.001. Online ahead of print. ABSTRACT Epithelial barriers such as the skin, lung, and gut, in addition to having unique physiologic functions, are designed to preserve tissue homeostasis upon challenge with a variety of allergens, irritants, or pathogens. Both the innate and adaptive immune systems play a critical role … Read more