Mucosal Immunology

IL-33 is associated with alveolar dysfunction in patients with viral lower respiratory tract disease. Ian C Scott

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Mucosal Immunol. 2024 Dec 9:S1933-0219(24)00124-7. doi: 10.1016/j.mucimm.2024.12.001. Online ahead of print. ABSTRACT Interleukin (IL)-33 is released following tissue damage, causing airway inflammation and remodelling via reduced IL-33 (IL-33red)/serum stimulation-2 (ST2) and oxidised IL-33 (IL-33ox)/receptor for advanced glycation end products (RAGE)/epidermal growth factor receptor (EGFR) pathways. This study aimed to identify associations of IL-33 with clinical … Read more

Early life microbiota colonization programs nociceptor sensitivity by regulating NGF production in mast cells. Nasser S Abdullah

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Mucosal Immunol. 2024 Dec 9:S1933-0219(24)00125-9. doi: 10.1016/j.mucimm.2024.12.002. Online ahead of print. ABSTRACT Recent evidence suggests that the gut microbiota can influence pain sensitivity, highlighting the potential for microbiota-targeted pain interventions. During early life, both the microbiota and nociceptors are fine-tuned and respond to environmental factors, however, little is known about how they interact with each … Read more

Wnt/β-catenin maintains epithelial IL-33 in the colonic stem and progenitor cell niche and drives its induction in colitis. Michael A Schumacher

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Mucosal Immunol. 2024 Nov 24:S1933-0219(24)00115-6. doi: 10.1016/j.mucimm.2024.11.007. Online ahead of print. ABSTRACT Interleukin (IL)-33 is a key responder to intestinal injury and inflammation. In the colon, it is expressed by several cell populations, with the specific cellular source likely determining its role. The colonic epithelium expresses IL-33; however, the factors controlling its production and the … Read more

Neutrophil subsets enhance the efficacy of host-directed therapy in pneumococcal pneumonia. Laura Matarazzo

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Mucosal Immunol. 2024 Nov 24:S1933-0219(24)00117-X. doi: 10.1016/j.mucimm.2024.11.009. Online ahead of print. ABSTRACT Host-directed therapy, using nasal administration of the Toll-like receptor 5 agonist flagellin in combination with antibiotics, has proven effective against pneumococcal pneumonia. In this study, we investigated the immune mechanisms underlying the therapy-induced protective effects. Transcriptomic analysis of lung tissue during infection revealed … Read more

Gut-homing and intestinal TIGITnegCD38+ memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn’s disease patients with a severe disease course. Maud Heredia

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Mucosal Immunol. 2024 Nov 23:S1933-0219(24)00116-8. doi: 10.1016/j.mucimm.2024.11.008. Online ahead of print. ABSTRACT CD4+ memory T cell (TM) reactivation drives chronicity in inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis. Defects driving loss of TM regulation likely differ between patients but remain undefined. In health, approximately 40 % of circulating gut-homing CD38+TM, express … Read more

IgA facilitates the persistence of the mucosal pathogen Helicobacter pylori. Mariela Artola-Borán

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Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00113-2. doi: 10.1016/j.mucimm.2024.11.006. Online ahead of print. ABSTRACT IgA antibodies have an important role in clearing mucosal pathogens. In this study, we have examined the contribution of IgA to the immune control of the gastrointestinal bacterial pathogens Helicobacter pylori and Citrobacter rodentium. Both bacteria trigger a strong local IgA response that … Read more

Herpes stromal keratitis erodes the establishment of tissue-resident memory T cell pool in HSV-1 infected corneas. Mizumi Setia

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Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00111-9. doi: 10.1016/j.mucimm.2024.11.003. Online ahead of print. ABSTRACT The recurrent herpes simplex virus-1 (HSV-1) infection of the cornea can cause the development of herpes stromal keratitis (HSK). This chronic immunoinflammatory condition is a major cause of infection-induced vision loss. The previous episodes of HSK increase the risk of future recurrences in … Read more

The C-type lectin receptor MINCLE interferes with eosinophil function and protective intestinal immunity in Strongyloides ratti-infected mice. Lara Linnemann

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Mucosal Immunol. 2024 Nov 22:S1933-0219(24)00114-4. doi: 10.1016/j.mucimm.2024.11.005. Online ahead of print. ABSTRACT Strongyloides ratti is a helminth parasite that displays tissue-migrating and intestinal life stages. Myeloid C-type lectin receptors (CLRs) are pattern recognition receptors that recognize pathogen-derived ligands and initiate immune responses. To date, the role of CLRs in S. ratti infection has not been … Read more

Card9 and MyD88 differentially regulate Th17 immunity to the commensal yeast Malassezia in the murine skin. Meret Tuor

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Mucosal Immunol. 2024 Nov 21:S1933-0219(24)00112-0. doi: 10.1016/j.mucimm.2024.11.004. Online ahead of print. ABSTRACT The fungal community of the skin microbiome is dominated by a single genus, Malassezia. Besides its symbiotic lifestyle at the host interface, this commensal yeast has also been associated with diverse inflammatory skin diseases in humans and pet animals. Stable colonization is maintained … Read more

Activation of α2B/2C adrenergic receptor ameliorates ocular surface inflammation through enhancing regulatory T cell function. Nai-Wen Fan

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Mucosal Immunol. 2024 Nov 8:S1933-0219(24)00110-7. doi: 10.1016/j.mucimm.2024.11.002. Online ahead of print. ABSTRACT There is an unmet need for effectively treating dry eye disease (DED), a T cell-mediated chronic, inflammatory ocular surface disorder. Given the potential of nonneuronal adrenergic system in modulating T cell response, we herein investigated the therapeutic efficacy and the underlying mechanisms of … Read more

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