Mucosal Immunology

CSF1-dependent macrophage support matrisome and epithelial stress-induced keratin remodeling in Eosinophilic esophagitis. Taylor M Benson

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Mucosal Immunol. 2024 Sep 27:S1933-0219(24)00099-0. doi: 10.1016/j.mucimm.2024.09.006. Online ahead of print. ABSTRACT Atopic diseases such as Eosinophilic Esophagitis (EoE) often progress into fibrosis (FS-EoE), compromising organ function with limited targeted treatment options. Mechanistic understanding of FS-EoE progression is confounded by the lack of preclinical models and the heavy focus of research on eosinophils themselves. We … Read more

Dietary fiber promotes antigen presentation on intestinal epithelial cells and development of small intestinal CD4+CD8αα+ intraepithelial T cells. Naomi Rodriguez-Marino

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Mucosal Immunol. 2024 Sep 5:S1933-0219(24)00092-8. doi: 10.1016/j.mucimm.2024.08.010. Online ahead of print. ABSTRACT The impact of dietary fiber on intestinal T cell development is poorly understood. Here we show that a low fiber diet reduces MHC-II antigen presentation by small intestinal epithelial cells (IECs) and consequently impairs development of CD4+CD8αα+ intraepithelial lymphocytes (DP IELs) through changes … Read more

Deciphering the therapeutic potential of Myeloid-Specific JAK2 inhibition in acute respiratory distress syndrome. Shupei Gao

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Mucosal Immunol. 2024 Aug 21:S1933-0219(24)00089-8. doi: 10.1016/j.mucimm.2024.08.008. Online ahead of print. ABSTRACT Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by severe inflammation and pulmonary dysfunction. Despite advancements in critical care, effective pharmacological interventions for ARDS remain elusive. While Janus kinase 2 (JAK2) inhibitors have emerged as an innovative treatment for numerous autoinflammatory … Read more

CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages. Sally H Mohamed

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Mucosal Immunol. 2024 Aug 20:S1933-0219(24)00088-6. doi: 10.1016/j.mucimm.2024.08.007. Online ahead of print. ABSTRACT PLX5622 is a small molecular inhibitor of the CSF1 receptor (CSF1R) and is widely used to deplete macrophages within the central nervous system (CNS). We investigated the impact of PLX5622 treatment in wild-type C57BL/6 mice and discovered that one-week treatment with PLX5622 was … Read more

Combined plasma protein and Tmem profiling discern IBD-patient-immunotypes related to intestinal disease and treatment outcomes: Short title: Defining immunotypes in CD and UC. Maud Heredia

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Mucosal Immunol. 2024 Sep 25:S1933-0219(24)00097-7. doi: 10.1016/j.mucimm.2024.09.004. Online ahead of print. ABSTRACT Inflammatory bowel disease (IBD) chronicity results from memory T helper cell (Tmem) reactivation. Identifying patient-specific immunotypes is crucial for tailored treatment. We conducted a comprehensive study integrating circulating immune proteins and circulating Tmem, with intestinal tissue histology and mRNA analysis, in therapy-naïve pediatric … Read more

Dissecting the metabolic signaling pathways by which microbial molecules drive the differentiation of regulatory B cells. Maik Luu

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Mucosal Immunol. 2024 Sep 16:S1933-0219(24)00096-5. doi: 10.1016/j.mucimm.2024.09.003. Online ahead of print. ABSTRACT The host-microbiome axis has been implicated in promoting anti-inflammatory immune responses. Yet, the underlying molecular mechanisms of commensal-mediated IL-10 production by regulatory B cells (Bregs) are not fully elucidated. Here, we demonstrate that bacterial CpG motifs trigger the signaling downstream of TLR9 promoting … Read more

Controlling functional homeostasis of ileal resident macrophages by vitamin B12 during steady state and Salmonella infection in mice. Yong Ge

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Mucosal Immunol. 2024 Sep 8:S1933-0219(24)00091-6. doi: 10.1016/j.mucimm.2024.08.011. Online ahead of print. ABSTRACT Dietary micronutrients, particularly vitamin B12 (VB12), profoundly influence the physiological maintenance and function of intestinal cells. However, it is still unclear whether VB12 modulates the transcriptional and metabolic programming of ileal macrophages (iMacs), thereby contributing to intestinal homeostasis. Using multiomic approaches, we demonstrated … Read more

The kynurenine pathway regulated by intestinal innate lymphoid cells mediates postoperative cognitive dysfunction. Wan-Bing Dai

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Mucosal Immunol. 2024 Sep 7:S1933-0219(24)00095-3. doi: 10.1016/j.mucimm.2024.09.002. Online ahead of print. ABSTRACT Postoperative cognitive dysfunction (POCD) is a prevalent neurological complication that can impair learning and memory for days, months, or even years after anesthesia/surgery. POCD is strongly associated with an altered composition of the gut microbiota (dysbiosis), but the accompanying metabolic changes and their … Read more

MicroRNA-142 regulates gut associated lymphoid tissues and group 3 innate lymphoid cells. Luke B Roberts

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Mucosal Immunol. 2024 Sep 7:S1933-0219(24)00094-1. doi: 10.1016/j.mucimm.2024.09.001. Online ahead of print. ABSTRACT The transcriptomic signatures that shape responses of innate lymphoid cells (ILCs) have been well characterised, however post-transcriptional mechanisms which regulate their development and activity remain poorly understood. We demonstrate that ILC groups of the intestinal lamina propria express mature forms of microRNA-142 (miR-142), … Read more

Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice. Julie Drieu La Rochelle

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Mucosal Immunol. 2024 Sep 7:S1933-0219(24)00093-X. doi: 10.1016/j.mucimm.2024.08.012. Online ahead of print. ABSTRACT Inflammation of the ileum, or ileitis, is commonly caused by Crohn’s disease (CD) but can also accompany ulcerative colitis (backwash ileitis), infections or drug-related damage. Oxidative tissue injury triggered by reactive oxygen species (ROS) is considered part of the ileitis etiology. However, not … Read more

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