Mucosal Immunology

Mucosal Immunol. 2026 Mar 28:S1933-0219(26)00037-1. doi: 10.1016/j.mucimm.2026.03.013. Online ahead of print. ABSTRACT Eosinophils are key contributors to allergic pathology, however, increasingly eosinophils are described to have important roles in organ health and immunoregulation. The factors that define and regulate these diverse eosinophil functions remain poorly understood. Here we show the emergence of a lung-specific Siglec-Fhi … Read more

Mucosal Immunol. 2026 Mar 26:S1933-0219(26)00035-8. doi: 10.1016/j.mucimm.2026.03.011. Online ahead of print. ABSTRACT Biological sex differences in morbidity upon influenza A virus (IAV) infection are linked to stronger IFN-centered immune responses in females, yet the regulatory role of sex steroid receptors in immune cell subsets is incompletely understood. Lung-resident group 2 innate lymphoid cells (ILC2s) express … Read more

Mucosal Immunol. 2026 Mar 21:S1933-0219(26)00034-6. doi: 10.1016/j.mucimm.2026.03.010. Online ahead of print. ABSTRACT Macrophages play important roles in lung homeostasis and disease by interacting with their surrounding tissue microenvironment. Accordingly, macrophage metabolism and local metabolites shape immune responses in the lung. Here, I review the metabolic regulation of lung macrophages and regulation of lung immunity by … Read more

Mucosal Immunol. 2026 Mar 21:S1933-0219(26)00032-2. doi: 10.1016/j.mucimm.2026.03.008. Online ahead of print. ABSTRACT Mycoplasma pneumoniae (MP) infection directly damages lung tissue and triggers dysregulated immune responses, yet the immunopathology underlying the severe pneumonia remains unknown. Here we analyzed cellular and molecular features in the peripheral blood and bronchoalveolar lavage fluid from patients to define the systemic … Read more

Mucosal Immunol. 2026 Mar 19:S1933-0219(26)00033-4. doi: 10.1016/j.mucimm.2026.03.009. Online ahead of print. ABSTRACT Chronic airway inflammation is a central driver of asthma pathogenesis, in which macrophages play a pivotal role. While autophagy is known to regulate macrophage function, the specific molecular mechanisms linking autophagy to allergic airway inflammation remain unclear. Here, we identify macrophage sirtuin 6 … Read more

Mucosal Immunol. 2026 Mar 14:S1933-0219(26)00031-0. doi: 10.1016/j.mucimm.2026.03.007. Online ahead of print. ABSTRACT Infection with Mycobacterium tuberculosis can cause diverse lesions, such as necrotic pneumonia, which can contribute to tuberculosis progression and transmission between individuals. Despite advances in understanding the role of ATP-gated P2RX7 ion channels in the development of severe forms of the disease, the … Read more

Mucosal Immunol. 2026 Mar 14:S1933-0219(26)00025-5. doi: 10.1016/j.mucimm.2026.03.001. Online ahead of print. NO ABSTRACT PMID:41833470 | DOI:10.1016/j.mucimm.2026.03.001

Mucosal Immunol. 2026 Mar 8:S1933-0219(26)00029-2. doi: 10.1016/j.mucimm.2026.03.005. Online ahead of print. ABSTRACT The development of treatments for ulcerative colitis (UC) has seen significant advancements over recent years, focusing on new drugs, innovative approaches, and a deeper understanding of the disease mechanisms. Few however have been able to restore natural tolerance. The hookworm-derived recombinant Anti-Inflammatory Protein … Read more

Mucosal Immunol. 2026 Mar 8:S1933-0219(26)00028-0. doi: 10.1016/j.mucimm.2026.03.004. Online ahead of print. ABSTRACT Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by epithelial barrier dysfunction and type 2-dominant inflammation, yet the upstream regulatory mechanisms linking epithelial remodeling and immune activation remain poorly understood, and reliable biomarkers for eosinophilic CRSwNP (EOS CRSwNP) are limited. This study investigated … Read more

Mucosal Immunol. 2026 Mar 5:S1933-0219(26)00026-7. doi: 10.1016/j.mucimm.2026.03.002. Online ahead of print. ABSTRACT Post-COVID syndrome (PCS) is a complex condition that can emerge after recovery from SARS-CoV-2 infection, even in young, healthy individuals with mild acute illness. While the underlying mechanisms remain unclear, viral persistence and immune dysregulation are considered key contributors. This study investigates whether … Read more