Mucosal Immunology

Interaction between airway basal cells, mast cells and type 2 immunity contributes to epithelial barrier dysfunction in allergic rhinitis. Emma Ruysseveldt

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Mucosal Immunol. 2026 Feb 21:S1933-0219(26)00021-8. doi: 10.1016/j.mucimm.2026.02.004. Online ahead of print. ABSTRACT Basal cell dysfunction contributes to the pathophysiology of chronic inflammatory airway disorders and is linked to persistent epithelial barrier defects. Epithelial integrity dysfunction, basal cell hyperplasia and metaplasia have been described in allergic rhinitis (AR). However, it remains unclear how basal cell progenitor … Read more

Temporal Dissection of TGF-β signaling reveals differential impact during female reproductive mucosal CD8 resident memory T cell differentiation. Mohammad H Hasan

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Mucosal Immunol. 2026 Feb 19:S1933-0219(26)00022-X. doi: 10.1016/j.mucimm.2026.02.005. Online ahead of print. ABSTRACT Resident memory CD8 T cell (TRM) development progresses through distinct stages beginning with activation of naive T cells into effectors in lymphoid organs, trafficking of effectors to target tissue via blood, and final TRM differentiation at the tissue of residence under the influence … Read more

Mucosal IL-36 is a defining feature of severe paediatric bronchiolitis. Megan V C Barnes

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Mucosal Immunol. 2026 Feb 9:S1933-0219(26)00012-7. doi: 10.1016/j.mucimm.2026.01.012. Online ahead of print. ABSTRACT RATIONALE: Bronchiolitis is the commonest cause of hospital admission in children under the age of 1 year, most cases being due to respiratory syncytial virus (RSV) infection. The mechanisms causing infantile bronchiolitis are incompletely understood but include a deficient mucosal interferon response, neutrophilic … Read more

Indoor rewilding of laboratory mice recalibrates pulmonary mucosal immunity and mechanics. Mohamed Lala Bouali

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Mucosal Immunol. 2026 Feb 6:S1933-0219(26)00016-4. doi: 10.1016/j.mucimm.2026.02.003. Online ahead of print. ABSTRACT Laboratory mice raised under specific-pathogen-free (SPF) conditions experience restricted microbial and antigenic exposure, which favours an immature immune system and limits their translational value for respiratory research. While microbial enrichment in “dirty” mouse models restores immune maturation, its impact on integrated respiratory function … Read more

Fibroblasts sense commensal-derived metabolites and regulate group 2 innate lymphoid cells-dependent defense in the stomach. Naoko Satoh-Takayama

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Mucosal Immunol. 2026 Feb 5:S1933-0219(26)00007-3. doi: 10.1016/j.mucimm.2026.01.007. Online ahead of print. ABSTRACT Group 2 innate lymphoid cells (ILC2s) contribute to mucosal homeostasis and initiate immune responses against gastrointestinal pathogens, including those that target the stomach. However, the role of commensal bacteria in promoting stomach immunity is unknown. Here, we report that YL27, a commensal bacterium … Read more

EPICERTIN, an engineered variant of cholera toxin B subunit, promotes survival and a pro-remodeling macrophage phenotype for mucosal healing in colitis. Noel Verjan Garcia

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Mucosal Immunol. 2026 Feb 4:S1933-0219(26)00013-9. doi: 10.1016/j.mucimm.2026.01.013. Online ahead of print. ABSTRACT EPICERTIN, a modified cholera toxin B subunit (CTB), facilitates mucosal healing in preclinical colitis models, but its anti-inflammatory mechanisms remain unclear. Here, we investigated EPICERTIN’s effects on macrophages. In a dextran sulfate sodium-induced colitis mouse model, oral administration of EPICERTIN reduced neutrophil infiltration … Read more

Expression of CD103 facilitates localization and activation of CD4+ T cells within Mycobacterium tuberculosis lung-lesions. Thomas Lindenstrøm

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Mucosal Immunol. 2026 Feb 3:S1933-0219(26)00014-0. doi: 10.1016/j.mucimm.2026.02.001. Online ahead of print. ABSTRACT The spatial localization of CD4+ T cells within the Mycobacterium tuberculosis (Mtb)-infected lung is critical for optimal immunity. Here, we investigate the role of two E-cadherin binding receptors, CD103 and KLRG1. We demonstrate that KLRG1 restricts CD4+ T cells to the lung vasculature … Read more

Mycobacterium tuberculosis preferentially infects specific macrophage subsets in primate granulomas during the early stages of tuberculosis. Davide Pisu

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Mucosal Immunol. 2026 Feb 3:S1933-0219(26)00015-2. doi: 10.1016/j.mucimm.2026.02.002. Online ahead of print. ABSTRACT Tuberculosis (TB) is caused by Mycobacterium tuberculosis (Mtb) infection and defined by formation of granulomas, immune aggregates that can restrict or support bacterial replication. Macrophages are fundamental components of granulomas and TB pathogenesis, yet their population structure and functional diversity is incompletely understood. … Read more

Depletion of CX3CR1+ macrophages results in disrupted functionality and immune surveillance within epididymis and testis. D Ai

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Mucosal Immunol. 2026 Jan 30:S1933-0219(26)00011-5. doi: 10.1016/j.mucimm.2026.01.011. Online ahead of print. ABSTRACT A finely tuned immune regulation within the epididymis and testis is essential for male reproductive health. This balance is especially critical in the epididymis, where sperm mature and ascending infections frequently disrupt homeostasis, resulting in regionally different immune responses and potential long-term fertility … Read more

Gut trialogue: How diet influences mucosal immune system-microbiota interactions. Quentin Lamy-Besnier

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Mucosal Immunol. 2026 Jan 27:S1933-0219(26)00009-7. doi: 10.1016/j.mucimm.2026.01.009. Online ahead of print. ABSTRACT The relationship between the intestinal microbiota and the mucosal immune system is a key determinant of health in that it plays a pivotal role in managing pathogens and avoiding chronic inflammatory diseases. Diet is a central mediator of this relationship, influencing microbiota composition … Read more

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