Mucosal Immunology

Mucosal Immunol. 2026 Jan 27:S1933-0219(26)00010-3. doi: 10.1016/j.mucimm.2026.01.010. Online ahead of print. ABSTRACT Paneth cells are secretory intestinal epithelial cells most abundant in the ileum that contribute to gut homeostasis and innate immunity through secretion of antimicrobial peptides and intestinal stem cell factors. Dysfunction of Paneth cells has been implicated in various gastrointestinal disorders. Although regulation … Read more

Mucosal Immunol. 2026 Jan 23:S1933-0219(26)00008-5. doi: 10.1016/j.mucimm.2026.01.008. Online ahead of print. ABSTRACT Secondary bacterial pneumonia causes substantial morbidity and mortality following influenza A virus (IAV) infection, yet no therapies exist that address the underlying immune dysfunction and epithelial damage that predispose to bacterial superinfection. Here, we demonstrate that short-course intranasal treatment with LAT9997, a synthetic … Read more

Mucosal Immunol. 2026 Jan 20:S1933-0219(26)00006-1. doi: 10.1016/j.mucimm.2026.01.006. Online ahead of print. ABSTRACT Two studies in Nature Immunology by Jakob, Sterczyk et al. and Pirzgalska et al. show that neuron-derived vasoactive intestinal peptide (VIP) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its receptor VIPR1, VIP restrains secretory lineage expansion, balances type 1 and type … Read more

Mucosal Immunol. 2026 Jan 17:S1933-0219(26)00004-8. doi: 10.1016/j.mucimm.2026.01.004. Online ahead of print. ABSTRACT The mechanisms underlying innate lymphoid cell (ILC) development and function in the neonatal lung remain incompletely defined. ILCs are critical mediators of early-life innate immune responses in the lung. Dysregulation of ILC homeostasis has both immediate and long-lasting effects on lung health. We … Read more

Mucosal Immunol. 2026 Jan 16:S1933-0219(26)00005-X. doi: 10.1016/j.mucimm.2026.01.005. Online ahead of print. ABSTRACT Lung-trafficking helminth larvae drive an early pulmonary neutrophilic inflammation prior to the establishment of the hallmark Type 2 immune response. While IL-11 is known to play crucial roles in chronic inflammatory responses, its role in the mucosal immunity to helminth parasites has not … Read more

Mucosal Immunol. 2026 Jan 9:S1933-0219(26)00003-6. doi: 10.1016/j.mucimm.2026.01.003. Online ahead of print. ABSTRACT Silicosis is an inflammation-driven pulmonary fibrosis caused by occupational inhalation of silica particles. Macrophages are crucial in silicosis pathology, yet their interaction with stromal cells in orchestrating fibrosis progression remains poorly understood. Single-cell RNA sequencing (scRNAseq) of whole-lung lavages from silicosis patients identified … Read more

Mucosal Immunol. 2026 Jan 8:S1933-0219(26)00001-2. doi: 10.1016/j.mucimm.2026.01.001. Online ahead of print. ABSTRACT T cells play a central role in host protection against respiratory pathogens, but a maladaptive T cell response can lead to pulmonary diseases. Previous studies have examined T cells from the lungs captured via bronchoalveolar lavage (BAL), endobronchial brushings, or biopsies. However, whether … Read more

Mucosal Immunol. 2026 Jan 7:S1933-0219(26)00002-4. doi: 10.1016/j.mucimm.2026.01.002. Online ahead of print. ABSTRACT Type 2 cytokinerelease promotes wound healing and helminth clearance, but it remains unclearwhethergroup 2 innate lymphocytes (ILC2s) and T-helper2 cells (TH2) cells have functionally distinctroles during anamnestic immunity. This study demonstrates that ILC2 can prevent re-infection andlimit tissue injury caused by the helminthNippostrongylus … Read more

Mucosal Immunol. 2025 Dec 30:S1933-0219(25)00141-2. doi: 10.1016/j.mucimm.2025.12.005. Online ahead of print. ABSTRACT The intestinal epithelium undergoes robust maturation postnatally, yet its early-life characteristics remain poorly understood. Using single-cell RNA sequencing, we analyzed intestinal epithelial cells from neonatal (10-day-old) and juvenile (21-day-old) mice reared under both specific pathogen-free and germ-free conditions. Among the various cell types … Read more

Mucosal Immunol. 2025 Dec 30:S1933-0219(25)00142-4. doi: 10.1016/j.mucimm.2025.12.006. Online ahead of print. NO ABSTRACT PMID:41478462 | DOI:10.1016/j.mucimm.2025.12.006