Nature Reviews Immunology, Published online: 02 July 2026; doi:10.1038/s41577-026-01322-1This Review traces the development of chimeric antigen receptor (CAR) T cell therapy from foundational immunology to approved products, highlighti…
Nature Reviews Immunology, Published online: 01 July 2026; doi:10.1038/s41577-026-01327-wThis Review discusses the origins and roles of macrophages in embryonic development. The authors highlight the importance of macrophages for devel…
Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038/s41577-026-01333-yA preprint by Serganova, Colombo et al. shows that tumour glycolytic capacity drives vascular abnormalities that influence the response to immunot…
Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038/s41577-026-01332-zA preprint by Vick et al. reports a crucial role for vaginal NK cells in maintaining epithelial integrity during infection.
Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038/s41577-026-01328-9In this Viewpoint, eight experts from the field of T cell exhaustion discuss current understanding of the self-renewing population of PD1+TCF1+TOX…
Nature Reviews Immunology, Published online: 30 June 2026; doi:10.1038/s41577-026-01318-xT cell engagers reprogramme T cells to eliminate pathogenic cell populations and are now emerging as a promising biologic strategy for autoimmune …
Nature Reviews Immunology, Published online: 23 June 2026; doi:10.1038/s41577-026-01325-yTwentieth-century immunology was shaped by questions of recognition, diversity, response and tolerance. The next era may be defined by a different…
Nature Reviews Immunology, Published online: 22 June 2026; doi:10.1038/s41577-026-01329-8A preprint by Hu et al. shows, in a mouse model of primary tauopathy, that conventional type 1 dendritic cells outside of the central nervous syst…
Nature Reviews Immunology, Published online: 19 June 2026; doi:10.1038/s41577-026-01316-zThis article leverages existing preclinical and clinical evidence to propose an immunological framework that reconciles four axes controlling the …
Nature Reviews Immunology, Published online: 15 June 2026; doi:10.1038/s41577-026-01324-zA preprint by Teodoro-Castro et al. reports a nuclear role for STING in impairing DNA replication and contributing to replication stress in ageing…
