Trogocytosis of CARs depends on transmembrane domains
Nature Reviews Immunology, Published online: 14 February 2025; doi:10.1038/s41577-025-01146-5Trogocytosis of CARs depends on transmembrane domains
Nature Reviews Immunology
Meningeal T<sub>reg</sub> cells keep brain in balance
Nature Reviews Immunology, Published online: 14 February 2025; doi:10.1038/s41577-025-01148-3A study in Science Immunology shows that meningeal regulatory T (Treg) cells limit the activation, proliferation and parenchymal infiltration …
Immune-mediated strategies to solving the HIV reservoir problem
Nature Reviews Immunology, Published online: 13 February 2025; doi:10.1038/s41577-025-01136-7HIV infection persists under antiretroviral therapy due to a reservoir of latently infected cells. This Perspective discusses how host immune …
HDAC9 association with heart disease linked to NLRP3 inflammasome activation
Nature Reviews Immunology, Published online: 12 February 2025; doi:10.1038/s41577-025-01144-7Loss of a conserved cis-regulatory element at HDAC9 increases NLRP3 inflammasome activation and may explain why HDAC9 is a major risk locus fo…
Faulty mitochondria jump between tumours and T cells
Nature Reviews Immunology, Published online: 07 February 2025; doi:10.1038/s41577-025-01143-8To evade elimination by T cells, tumour cells transfer mutant mitochondria to T cells, which reprogrammes their metabolism and compromises the…
B cells in non-lymphoid tissues
Nature Reviews Immunology, Published online: 05 February 2025; doi:10.1038/s41577-025-01137-6B cells are major drivers of systemic immunity, but they also act locally in non-lymphoid organs. This Review highlights new insights into mec…
Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors
Nature Reviews Immunology, Published online: 03 February 2025; doi:10.1038/s41577-025-01135-8Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors
Trained immunity in chronic inflammatory diseases and cancer
Nature Reviews Immunology, Published online: 31 January 2025; doi:10.1038/s41577-025-01132-xBesides its beneficial effects against infection, trained immunity has recently been implicated in inflammation-related disorders and is being …
Podoplanin mediates stromal–immune crosstalk in the lymph node
Nature Reviews Immunology, Published online: 31 January 2025; doi:10.1038/s41577-025-01140-xA preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in lymph nodes, by modula…
Immune control of brain physiology
Nature Reviews Immunology, Published online: 31 January 2025; doi:10.1038/s41577-025-01129-6The peripheral immune system communicates with the brain through diverse anatomical routes to shape brain physiology. Here we discuss why such …