Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses
Science Immunology, Volume 9, Issue 96, June 2024.
Publicaciones
Overexpression of Malat1 drives metastasis through inflammatory reprogramming of the tumor microenvironment
Science Immunology, Volume 9, Issue 96, June 2024.
Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening
Science Immunology, Volume 9, Issue 96, June 2024.
Sialic acids on T cells are crucial for their maintenance and survival
Sialic acids are found as terminal sugars on glycan structures on cellular surfaces. T cells carry these sialoglycans abundantly, and they are thought to serve multiple functions in cell adhesion, cell migration, and protection from complement attack. …
Second bone marrow transplantation into regenerating hematopoiesis enhances reconstitution of immune system
In bone marrow transplantation (BMT), hematopoiesis-reconstituting cells are introduced following myeloablative treatment, which eradicates existing hematopoietic cells and disrupts stroma within the hematopoietic tissue. Both hematopoietic cells and s…
Identification and experimental validation of cuproptosis regulatory program in a sepsis immune microenvironment through a combination of single-cell and bulk RNA sequencing
BackgroundIn spite of its high mortality rate and poor prognosis, the pathogenesis of sepsis is still incompletely understood. This study established a cuproptosis-based risk model to diagnose and predict the risk of sepsis. In addition, the cuproptosi…
Severe thermal and major traumatic injury results in elevated plasma concentrations of total heme that are associated with poor clinical outcomes and systemic immune suppression
BackgroundTraumatic and thermal injuries result in a state of systemic immune suppression, yet the mechanisms that underlie its development are poorly understood. Released from injured muscle and lysed red blood cells, heme is a damage associated molec…
Vaccines for Streptococcus agalactiae: current status and future perspectives
A maternal vaccine to protect newborns against invasive Streptococcus agalactiae infection is a developing medical need. The vaccine should be offered during the third trimester of pregnancy and induce strong immune responses and placental transfer of …
C-reactive protein: structure, function, regulation, and role in clinical diseases
C-reactive protein (CRP) is a plasma protein that is evolutionarily conserved, found in both vertebrates and many invertebrates. It is a member of the pentraxin superfamily, characterized by its pentameric structure and calcium-dependent binding to lig…