BackgroundAnoikis is a form of programmed cell death essential for preventing cancer metastasis. In some solid cancer, anoikis resistance can facilitate tumor progression. However, this phenomenon is underexplored in clear-cell renal cell carcinoma (cc…
ObjectivesMast cell (MC) degranulation is a key process in allergic reactions and inflammatory responses. Aspartate aminotransferase 1 (AAT1)-derived endogenous sulfur dioxide (SO2) is an important regulator of MC function. However, the mechanism under…
IntroductionEquine asthma (EA) is a common lower airway disease in horses, but whether its pathogenesis is allergic is ambiguous. Extrinsic stimuli like hay dust induce acute exacerbation of clinical signs and sustained local neutrophilic inflammation …
Background and objectivesAntiglycine receptor (anti-GlyR) antibody mediates multiple immune-related diseases. This study aimed to summarize the clinical features to enhance our understanding of anti-GlyR antibody-related disease.MethodsBy collecting cl…
IntroductionHuman Herpesvirus 6B (HHV-6B) impedes host immune responses by downregulating class I MHC molecules (MHC-I), hindering antigen presentation to CD8+ T cells. Downregulation of MHC-I disengages inhibitory receptors on natural killer (NK) cell…
The predominant characteristic of autoimmune gastritis (AIG) is corpus-dominant advanced atrophy, which is mostly observed in the middle to late stages. More reports are needed on the endoscopic features of the early stage. In this report, we present t…
Dietary restriction is associated with improved elimination of cancer cells, and fasting regimens are being tested in clinical settings in combination with cancer therapies. Using a cyclic fasting diet (CFD), Delconte et al. show that natural killer (N…
Aicardi-Goutières syndrome is an autoinflammatory brain disease associated with increased interferon-α production, but the primary source and mediators of neurotoxicity are poorly described. Viengkhou et al. show that neurotoxic interferon-α originates…
Science Immunology, Volume 9, Issue 96, June 2024.
