Although it is known that pro- and anti-inflammatory neutrophils exist, the mechanisms that dictate their polarization remain unclear. Gour et al. report that neutrophils express a canonical neuronal receptor, Mrgpra1, and a neuropeptide ligand, neurop…
Tuft cells are central regulators of type 2 immunity in the intestine. Eshleman et al. reveal that commensal bacterial-derived butyrate restricts stem cell development into tuft cells through the epigenetic-modifying enzyme HDAC3. The microbiota can th…
Aging induces cellular senescence of immune cells, yet the underlying mechanism is poorly understood. Here, Zhou et al. reveal that type 2 cytokine signaling protects macrophages from senescence by directly sustaining DNA repair. They further show that…
High-affinity cells are proposed to preferentially develop into long-lived plasma cells. Sutton et al. examine the differentiation of Ighg2A10 B cells, specific for the Plasmodium falciparum circumsporozoite protein (PfCSP), and find that cells initiat…
Annual Review of Immunology, Volume 41, Issue 1, Page 453-481, April 2023.
Annual Review of Immunology, Volume 41, Issue 1, Page 73-98, April 2023.
Annual Review of Immunology, Volume 41, Issue 1, Page 277-300, April 2023.
Annual Review of Immunology, Volume 41, Issue 1, Page 375-404, April 2023.
Annual Review of Immunology, Volume 41, Issue 1, Page 229-254, April 2023.
Annual Review of Immunology, Volume 41, Issue 1, Page 301-316, April 2023.
