The Journal of Immunology

J Immunol. 2026 Aug 29;215(9):vkag256. doi: 10.1093/jimmun/vkag256. ABSTRACT The expression, localization, and secretion of certain chromatin proteins are tightly regulated in response to inflammatory challenges or tissue damage. High mobility group (HMG) nucleosome-binding proteins can translocate out of the nucleus to act as alarmins in immune cell communications. The consequences of nuclear depletion of HMGs … Read more

J Immunol. 2026 Aug 29;215(9):vkag254. doi: 10.1093/jimmun/vkag254. ABSTRACT Obesity is a risk factor for severe respiratory viral infections, but its impact on bacterial respiratory diseases remains unclear and is sometimes paradoxical. Herein, we demonstrate that diet-induced obese, male C57BL/6J mice exhibited increased resistance to pulmonary infection with Francisella tularensis and Bordetella pertussis compared with lean … Read more

J Immunol. 2026 Aug 29;215(9):vkag239. doi: 10.1093/jimmun/vkag239. NO ABSTRACT PMID:42763889 | DOI:10.1093/jimmun/vkag239

J Immunol. 2026 Aug 29;215(9):vkag242. doi: 10.1093/jimmun/vkag242. ABSTRACT Laboratory-raised specific pathogen-free (SPF) mice have been indispensable for fundamental immunology research, yet their reliability in predicting human clinical outcomes has been questionable. A major factor contributing to this disconnect is the sanitized housing environment, which deprives laboratory mice of physiological microbial exposure critical for immune maturation. … Read more

J Immunol. 2026 Aug 29;215(9):vkag248. doi: 10.1093/jimmun/vkag248. ABSTRACT Clonal hematopoiesis of indeterminate potential (CHIP) arises from age-related somatic mutations in hematopoietic stem cells in the bone marrow (BM), driving clonal expansion and altered phenotypes. Loss-of-function mutations in the epigenetic regulator TET2 are among the most frequent in CHIP and increase the risk of hematologic malignancies … Read more

J Immunol. 2026 Aug 29;215(9):vkag243. doi: 10.1093/jimmun/vkag243. ABSTRACT Despite the central role of major histocompatibility complex (MHC) class II in adaptive immunity, peptide-binding motifs have yet to be characterized for any canine MHC class II allele. Here, we report the first immunopeptidomics-derived binding motifs for DLA-DRB1*015:01 (DLA-DR15) and DLA-DRB1*012:01 (DLA-DR12), 2 alleles overrepresented in breeds … Read more

J Immunol. 2026 Aug 29;215(9):vkag246. doi: 10.1093/jimmun/vkag246. ABSTRACT The dynamic interplay between pro- and anti-inflammatory cytokines plays a crucial role in regulating host immune responses. In our earlier study, we showed that Leishmania donovani-induced IL-33 destabilizes host cytokine dynamics by downregulating TNF-α and IL-12 and ensures intramacrophage parasite survival. Another pertinent host favorable proinflammatory cytokine … Read more

J Immunol. 2026 Aug 29;215(9):vkag247. doi: 10.1093/jimmun/vkag247. ABSTRACT SWI/SNF chromatin remodeling complexes regulate gene expression during development and differentiation. These complexes exist in distinct forms, including the polybromo-associated BAF (PBAF) complex, defined by the ARID2 subunit. ARID2 is frequently mutated in B cell leukemias, but its role in normal B cell development remains unknown. Using … Read more

J Immunol. 2026 Aug 29;215(9):vkag179. doi: 10.1093/jimmun/vkag179. ABSTRACT Psoriasis is a chronic inflammatory skin disease involving intricate neuroimmune crosstalk. However, the specific mechanisms and therapeutic targets remain elusive. In this study, a pilot clinical trial demonstrated that intravenous scopolamine, a muscarinic receptor antagonist, significantly ameliorated skin lesions in psoriasis patients. Consistently, scopolamine reduced inflammation in … Read more

J Immunol. 2026 Aug 29;215(9):vkag233. doi: 10.1093/jimmun/vkag233. ABSTRACT Psoriasis is a chronic, immune-mediated inflammatory skin disease affecting at least 2% of the global population. Papaverine, an alkaloid with known anti-inflammatory, anti-cancer, and RAGE-antagonistic properties, has not been previously evaluated for anti-psoriatic activity. This study investigated the protective effects and mechanisms of papaverine in an imiquimod … Read more