J Immunol. 2026 Aug 4;215(8):vkag191. doi: 10.1093/jimmun/vkag191. ABSTRACT Metastatic disease is the prime cause of death from many malignancies. Due to the multiple different lesions and the increased aggressiveness of the cancer cells, metastatic disease is often difficult to treat. Here, the introduction of immune checkpoint blockers (ICBs) has greatly helped to improve patients’ prognosis … Read more
J Immunol. 2026 Aug 4;215(8):vkag231. doi: 10.1093/jimmun/vkag231. ABSTRACT Antibody-secreting cells (ASCs) are critical effectors of humoral immunity, wherein their distinct isotypes play specialized roles in pathogen defense. Despite studies defining the transcriptional programs of selected ASC isotypes, specific mechanisms underlying isotype-specific gene regulation are largely unaddressed. Here, we performed an integrated multiomics analysis (RNA sequencing, … Read more
J Immunol. 2026 Aug 4;215(8):vkag152. doi: 10.1093/jimmun/vkag152. ABSTRACT The gastrointestinal pathogen Clostridioides difficile is a major burden for health systems due to high rates of recurrence. C. difficile pathogenesis is mediated by two virulence factors, toxin A (TcdA) and toxin B (TcdB). Antibodies specific for TcdA and TcdB are correlated with protection from symptomatic recurrence; … Read more
J Immunol. 2026 Aug 4;215(8):vkag207. doi: 10.1093/jimmun/vkag207. ABSTRACT Sex differences exist in the immune responses to infections and in the prevalence and severity of autoimmune and allergic diseases. These sex differences may be caused by sex hormones and/or variable inactivation of X chromosome genes. The 4 core genotypes mice allow for distinction between the effects … Read more
J Immunol. 2026 Aug 4;215(8):vkag220. doi: 10.1093/jimmun/vkag220. ABSTRACT Little is known about the role of semaphorin 3E (Sema3E) in B cell responses and immunoglobulin regulation. Our recent data indicate that Sema3e knockout mice have significantly higher serum levels of total and allergen-specific IgE in allergic asthma, suggesting Sema3E’s crucial role in modulating the humoral response. … Read more
J Immunol. 2026 Aug 4;215(8):vkag219. doi: 10.1093/jimmun/vkag219. ABSTRACT Systemic sclerosis (SSc) is an autoimmune condition affecting several organs. It is identified by thickening of the dermis, connective tissue affected by collagen accumulation, and vascular injuries that induce hypoxia. The present study aimed to determine whether extracellular vesicles (EVs) from adipose-derived stem cells (ADSCs) attenuated bleomycin-induced … Read more
J Immunol. 2026 Aug 4;215(8):vkag228. doi: 10.1093/jimmun/vkag228. ABSTRACT Sepsis-induced cardiac dysfunction is a primary contributor to mortality, and microRNAs (miRNAs) are recognized as crucial mediators in sepsis pathogenesis. This study aims to identify the key regulatory miRNAs involved in cardiac dysfunction stemming from sepsis. We developed a rat model of sepsis using cecal ligation and … Read more
J Immunol. 2026 Aug 4;215(8):vkag198. doi: 10.1093/jimmun/vkag198. ABSTRACT Type 1 conventional dendritic cells (cDC1s) are important for generating and sustaining antitumor immunity. Accordingly, the abundance of cDC1s in human tumors correlates with improved outcomes in cancer. Capitalizing on this role, we previously demonstrated that vaccination with murine cDC1s, generated in culture from bone marrow cells … Read more
J Immunol. 2026 Aug 4;215(8):vkag212. doi: 10.1093/jimmun/vkag212. ABSTRACT Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that recognizes bacterial-derived antigens presented on MR1. Upon TCR triggering, MAIT cells respond rapidly, producing a range of effector molecules which facilitate host-protective responses in the context of microbial infections. In contrast, MAIT cell responses … Read more
J Immunol. 2026 Aug 4;215(8):vkag200. doi: 10.1093/jimmun/vkag200. ABSTRACT Lysosomes drive antigen proteolysis and peptide loading for major histocompatibility complex class II (MHCII) presentation in antigen-presenting cells (APCs), enabling activation of peptide-specific CD4+ T helper cells (CD4+ Th cells). Tight regulation of endocytic trafficking, protease activity, and peptide editing is required to generate stable peptide-MHCII complexes … Read more
