J Immunol. 2026 Oct 1;215(10):vkag284. doi: 10.1093/jimmun/vkag284. NO ABSTRACT PMID:42946974 | DOI:10.1093/jimmun/vkag284
J Immunol. 2026 Oct 1;215(10):vkag271. doi: 10.1093/jimmun/vkag271. ABSTRACT Mucosa-associated invariant T (MAIT) cells are innate-like MR1-restricted T cells broadly distributed in human tissues. MAIT cells adapt their antigen-specific response patterns depending on cytokine cues such as IL-12 or IL-18 in the microenvironment, shifting toward either IL-10+ or IL-17+ profiles. However, if such patterns are maintained … Read more
J Immunol. 2026 Oct 1;215(10):vkag286. doi: 10.1093/jimmun/vkag286. ABSTRACT We investigated the development, antigen specificity, and effector functions of PD-1- and PD-1+ CXCR5+CD8+ T-cell subsets in transplant mice with acute murine cytomegalovirus (MCMV) infection. MCMV-primed (MCMV-Tet+) or alloprimed (MCMV-Tet-) CD8+ T cells from C57BL/6 mice were flow-sorted and adoptively transferred into MCMV-infected CD8 knockout transplant recipients. … Read more
J Immunol. 2026 Oct 1;215(10):vkag274. doi: 10.1093/jimmun/vkag274. ABSTRACT A new human xeno-free T cell expansion strategy enabled T cell receptor α/β (TCRα/β)-driven autologous reactivity and continuous long-term IL-2-dependent expansion of an unconventional professional T cell antigen-presenting cell (T-APC) subset. Autologous T-APC cultures were obtained from small peripheral blood mononuclear cell samples that yielded over 1020-fold … Read more
J Immunol. 2026 Oct 1;215(10):vkag272. doi: 10.1093/jimmun/vkag272. ABSTRACT Major histocompatibility complex class Ia (MHC-Ia)-restricted CD8⁺ T cell responses play a central role in the host defense against HIV-1, with certain MHC-Ia alleles known to be associated with cytotoxic T lymphocyte responses having an increased potential for viral control. However, the impact of immune aging on … Read more
J Immunol. 2026 Oct 1;215(10):vkag257. doi: 10.1093/jimmun/vkag257. ABSTRACT Cryopyrin-associated periodic syndrome (CAPS) is an autoinflammatory disease caused by gain-of-function mutations in human nucleotide-binding domain, leucine-rich repeat-containing protein 3 (NLRP3), which lead to constitutive inflammasome activation and excessive IL-1β secretion. Long-term IL-1 blockade has markedly improved patient outcomes by preventing systemic inflammation and amyloidosis. However, whether … Read more
J Immunol. 2026 Oct 1;215(10):vkag269. doi: 10.1093/jimmun/vkag269. ABSTRACT CD8+ tissue-resident memory T cells (TRM) in the upper respiratory tract (URT) limit viral replication after transmission and prevent spread to the lower respiratory tract (LRT), whereas LRT CD8+ TRM are important for limiting immunopathology in the lung and promoting efficient viral clearance. Although the presence of … Read more
J Immunol. 2026 Oct 1;215(10):vkag276. doi: 10.1093/jimmun/vkag276. ABSTRACT CTLA-4 is an inhibitory receptor on T cells that limits immune activation by competing with the co-stimulatory receptor CD28 for binding to CD80 and CD86 on antigen-presenting cells. Regulatory T cells (Tregs) employ CTLA-4-mediated transendocytosis as a key suppressive mechanism. Several CTLA4 polymorphisms are associated with autoimmune … Read more
J Immunol. 2026 Oct 1;215(10):vkag270. doi: 10.1093/jimmun/vkag270. ABSTRACT HLA-A*02:01-restricted PB1413+CD8+ T cells provide the broadest reported cross-reactive immunity against influenza A, B, and C viruses. Here, we investigated T cell receptor (TCR) clonotypic signatures within these universal A2/PB1413+CD8+ T cell pools, compared with immunodominant influenza A-specific M158+CD8+ T cells and codominant influenza B-specific A2/HA543+CD8+ memory … Read more
J Immunol. 2026 Oct 1;215(10):vkag268. doi: 10.1093/jimmun/vkag268. ABSTRACT Multiple sclerosis (MS) is thought to be mediated by human leukocyte antigen (HLA) class II-restricted autoreactive CD4 T cells producing interleukin (IL)-17A and/or interferon γ (IFNγ), but the necessity of these cytokines for disease pathogenesis is unclear. Utilizing HLA-DR3 (DRβ1*0301) transgenic mice lacking IFNγ or IL-17A in … Read more
