The Journal of Immunology

Human XIRP1 is a new podosome protein targeting cytosolic bacteria as part of the IFN-γ defense program

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J Immunol. 2026 Jun 7;215(6):vkag116. doi: 10.1093/jimmun/vkag116. ABSTRACT Interferon-gamma (IFN-γ) is a powerful transactivating signal eliciting hundreds of IFN-stimulated genes (ISGs) in humans to help combat infection. Most ISGs remain uncharacterized, and here we searched for actin-binding candidates that could potentially target intracellular pathogens to block their spread or promote immune cell migration into infected … Read more

Congenital cytomegalovirus infection drives oligoclonal expansion of cytotoxic γδ T cells from early fetal progenitors

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J Immunol. 2026 Jun 7;215(6):vkag099. doi: 10.1093/jimmun/vkag099. ABSTRACT Gamma delta (γδ) T cells emerge early during human gestation and are uniquely equipped to protect the fetus and infant following infection, due to their innate-like recognition of conserved molecular ligands. Following congenital cytomegalovirus infection (cCMV), Vδ1 T cells have been shown to expand, differentiate, and upregulate … Read more

p120-catenin enhances macrophage efferocytosis and facilitates resolution of lung inflammatory injury

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J Immunol. 2026 Jun 7;215(6):vkag109. doi: 10.1093/jimmun/vkag109. ABSTRACT Defective resolution of inflammation following sepsis contributes to persistent immune dysfunction and increased morbidity and mortality worldwide. Efficient clearance of apoptotic polymorphonuclear neutrophils (PMNs) by macrophages, a process known as efferocytosis, is essential for resolving inflammation, promoting tissue repair, and restoring immune homeostasis; however, the molecular mechanisms … Read more

Parenteral vaccination protects against mucosal Salmonella infection by inducing liver tissue resident memory CD4 T cells

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J Immunol. 2026 Jun 7;215(6):vkag138. doi: 10.1093/jimmun/vkag138. ABSTRACT Salmonella enterica is a gastrointestinal pathogen that causes a variety of intestinal and systemic clinical disease. Vaccine development for systemic salmonellosis requires a deeper understanding of protective mechanisms and the relative contribution of mucosal and systemic host responses to bacterial elimination. Here, we examined the relative importance … Read more

A novel monocyte-derived antigen presenting cell-T regulatory cell axis contributes to skin wound healing and is impaired in diabetic mice

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J Immunol. 2026 Jun 7;215(6):vkag128. doi: 10.1093/jimmun/vkag128. ABSTRACT Despite a vast literature on the role of macrophages in wound healing, the role of dermal monocyte (Mo)-derived antigen presenting cells (APC) has received scant attention. Using scRNAseq and flow cytometry, we identify a population of APC that is prominent in wounds of non-diabetic mice but is … Read more

Preselection CD4+CD8+ thymocytes modulate TCR responsiveness following TCRβ selection

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J Immunol. 2026 Jun 7;215(6):vkag105. doi: 10.1093/jimmun/vkag105. ABSTRACT Modulation of T cell receptor (TCR) sensitivity during positive selection is critical to avoid negative selection and direct thymocytes into their appropriate lineage. Thymocytes just prior to positive selection (preselection) are highly responsive to low affinity self-ligands and are also actively rearranging their TCRα locus as they … Read more

Variable fab domain N-glycosylation patterns in the B cell receptor repertoires of healthy individuals and patients with rheumatoid arthritis

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J Immunol. 2026 Jun 7;215(6):vkag113. doi: 10.1093/jimmun/vkag113. ABSTRACT N-linked glycosylation (N-glyc) sites (N-X-S/T, X≠P) can be introduced by somatic hypermutation in immunoglobulin Fab regions. In patients with rheumatoid arthritis (RA), anti-citrullinated protein antibodies have a striking overrepresentation of Fab N-glycosylation. To further explore this, we sequenced B cell receptors (BCRs) from peripheral blood of 13 … Read more

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