The Journal of Immunology

J Immunol. 2026 Apr 15;215(4):vkag080. doi: 10.1093/jimmun/vkag080. ABSTRACT The Modular Immune In vitro Construct (MIMIC) system is an established laboratory-based methodology that reproduces in vitro the human in vivo T-cell immune response. In this study, we utilized the MIMIC system to establish a dendritic cell and CD4+ T-cell co-culture model that recapitulates T helper cell … Read more

J Immunol. 2026 Apr 15;215(4):vkag005. doi: 10.1093/jimmun/vkag005. ABSTRACT In this study, we investigate the mechanisms by which ischemia-free liver transplantation (IFLT) mitigates ischemia-reperfusion injury (IRI) and identify key therapeutic targets. Clinical data from 200 patients were collected to evaluate perioperative recovery and overall outcomes. Liver tissues were obtained from donors at the preprocurement, end-of-preservation, and … Read more

J Immunol. 2026 Apr 15;215(4):vkag063. doi: 10.1093/jimmun/vkag063. ABSTRACT The concept of polyfunctional secretion, the ability of cells to secrete multiple, functionally distinct proteins, has received increased attention for B cells as they have been described to secrete both antibodies and cytokines. However, the functional analysis of B cells was mostly performed in bulk, and consequently, … Read more

J Immunol. 2026 Apr 15;215(4):vkag054. doi: 10.1093/jimmun/vkag054. ABSTRACT Memory B cells (MBCs) are an integral part of the humoral immune response with the capacity to both reseed germinal center reactions and rapidly form antibody-secreting plasma cells (ASCs) upon secondary antigen encounter. MBCs arise via both T cell-dependent and -independent routes and while CD4+ T cells … Read more

J Immunol. 2026 Apr 15;215(4):vkag050. doi: 10.1093/jimmun/vkag050. ABSTRACT Group 3 innate lymphoid cells (ILC3s) preserve intestinal barrier integrity by producing IL-22 and IL-17A, yet the molecular mechanisms that maintain these cytokines during inflammation are incompletely defined. Here, we identify DAB2IP as a cell-intrinsic regulator of ILC3 effector function. In human inflammatory bowel disease mucosa, DAB2IP … Read more

J Immunol. 2026 Apr 15;215(4):vkag019. doi: 10.1093/jimmun/vkag019. ABSTRACT T cell immunity depends on the precise coordination of signaling networks with actin cytoskeleton remodeling, yet the molecular regulators of these processes remain incompletely defined. Flightless-1 (FLII) is a gelsolin-family actin regulator with unique leucine-rich repeats that can couple cytoskeletal dynamics to diverse signaling pathways. Here, using … Read more

J Immunol. 2026 Apr 15;215(4):vkag011. doi: 10.1093/jimmun/vkag011. ABSTRACT At the heart of Lyon, France, two leading institutes, the Centre International de Recherche en Infectiologie and the Cancer Research Center of Lyon, have built strong immunology programs since their establishment in the early 2010s. Their collaborative spirit led to the creation of the Immune Responses in … Read more

J Immunol. 2026 Apr 15;215(4):vkag059. doi: 10.1093/jimmun/vkag059. ABSTRACT Myelodysplastic syndrome (MDS) is a heterogeneous group of myeloid neoplasms characterized by treatment difficulties and a propensity to progress to acute myeloid leukemia. Impaired natural killer (NK) cell surveillance is a hallmark of MDS, yet the underlying molecular mechanisms remain poorly understood. This study aims to elucidate … Read more

J Immunol. 2026 Apr 15;215(4):vkag058. doi: 10.1093/jimmun/vkag058. ABSTRACT Peritoneal cavity (PerC) B cells can be classified into distinct subpopulations; however, their differential antigen-presenting capabilities and roles in antitumor immune responses remain largely unexplored. This study aimed to elucidate the properties of PerC B cell subpopulations in antitumor immune responses by using ovalbumin (OVA) peptides as … Read more

J Immunol. 2026 Apr 15;215(4):vkag038. doi: 10.1093/jimmun/vkag038. ABSTRACT T cells utilize diverse T cell receptors (TCRs) to recognize antigenic peptides and mediate adaptive immunity. However, the organization and function of αβ T cells in early vertebrates remain poorly understood. Here, we systematically characterized the TCRα locus and αβ T cell responses in Nile tilapia (Oreochromis … Read more