The Journal of Immunology

J Immunol. 2025 Jun 12:vkaf100. doi: 10.1093/jimmun/vkaf100. Online ahead of print. ABSTRACT Modern antiretroviral therapy (ART) regimens have revolutionized the management of human immunodeficiency virus (HIV) and transformed it from a life-threatening disease to a manageable chronic condition. Despite the durable viral suppression associated with ART adherence, people with HIV (PWH) continue to experience chronic … Read more

J Immunol. 2025 Jun 12:vkaf111. doi: 10.1093/jimmun/vkaf111. Online ahead of print. ABSTRACT Colorectal cancer (CRC) progression is closely associated with the dynamic evolution of the tumor microenvironment. As a key component of the tumor microenvironment, tumor-associated neutrophils exhibit protumor properties and dynamically regulate malignant processes by secreting bioactive mediators that coordinate interactions among immune cells. … Read more

J Immunol. 2025 Jun 11:vkaf110. doi: 10.1093/jimmun/vkaf110. Online ahead of print. ABSTRACT Neutrophils are immune cells specialized in producing large amounts of reactive oxygen species (ROS) to kill microbes. However, the mechanisms by which these cells regulate the balance of different ROS species and mitigate oxidative stress remain unclear. Here, we demonstrate that superoxide dismutase … Read more

J Immunol. 2025 Jun 10:vkaf096. doi: 10.1093/jimmun/vkaf096. Online ahead of print. ABSTRACT Disease relapse is a major cause of death in acute myeloid leukemia (AML) patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The characterization of novel functional T-cell subtypes is critical for predicting clinical responses as well as developing strategies for immunotherapy in leukemia. … Read more

J Immunol. 2025 Jun 9:vkaf115. doi: 10.1093/jimmun/vkaf115. Online ahead of print. ABSTRACT This Pillars of Immunology article revisits the landmark 2007 study by Foster, Hargreaves, and Medzhitov-the first to uncover the mechanistic basis of memory in the innate immune system. This pivotal study marks a fundamental shift in our understanding of innate immunity, revealing an … Read more

J Immunol. 2025 Jun 9:vkaf114. doi: 10.1093/jimmun/vkaf114. Online ahead of print. ABSTRACT Pulmonary type 2 innate lymphocytes (ILC2s) show sex dimorphism in numbers, phenotype, and function. We used a novel strategy of competitive, mixed male-female donor bone marrow chimeras to determine if sex differences in murine ILC2s result from extrinsic factors in the recipient environment … Read more

J Immunol. 2025 Jun 5:vkaf134. doi: 10.1093/jimmun/vkaf134. Online ahead of print. NO ABSTRACT PMID:40474450 | DOI:10.1093/jimmun/vkaf134

J Immunol. 2025 Jun 4:vkaf152. doi: 10.1093/jimmun/vkaf152. Online ahead of print. NO ABSTRACT PMID:40468599 | DOI:10.1093/jimmun/vkaf152

J Immunol. 2025 Jun 2:vkaf103. doi: 10.1093/jimmun/vkaf103. Online ahead of print. ABSTRACT The cytokine-signaling inhibitor ruxolitinib causes disease flares of chronic lymphocytic leukemia (CLL). This tumor-promoting activity correlates with its ability to inhibit interleukin (IL)-10 production by CLL B cells that have been activated with IL-2 and the Toll-like receptor 7 (TLR7) agonist resiquimod (called … Read more

J Immunol. 2025 May 30:vkaf098. doi: 10.1093/jimmun/vkaf098. Online ahead of print. ABSTRACT Respiratory syncytial virus (RSV) is the leading cause of childhood respiratory infections worldwide. However, no vaccine is available for children, and treatment options are limited. Identification of host factors pivotal to viral replication or immune-inflammatory regulation may inform the development of novel therapies, … Read more