J Immunol. 2026 May 14;215(5):vkag002. doi: 10.1093/jimmun/vkag002. ABSTRACT Phosphoinositide 3-kinase (PI3K) mediates signaling downstream of many receptors expressed by B cells. Studies in both mice and humans have shown that PI3K plays a critical role in B-cell development, activation, and tolerance. Indeed the key role of PI3K in regulating activation versus tolerance is demonstrated by … Read more
J Immunol. 2026 May 14;215(5):vkag071. doi: 10.1093/jimmun/vkag071. NO ABSTRACT PMID:42153523 | DOI:10.1093/jimmun/vkag071
J Immunol. 2026 May 14;215(5):vkag075. doi: 10.1093/jimmun/vkag075. ABSTRACT Among the PI3K isoforms, PI3Kδ has attracted particular attention from immunologists and hematologists. Despite earlier clinical setbacks, the PI3Kδ field has recently re-emerged with renewed promise. Here, I highlight key milestones in the evolving understanding of PI3Kδ signaling in immunity and cancer, and pivotal studies that have … Read more
J Immunol. 2026 May 14;215(5):vkag085. doi: 10.1093/jimmun/vkag085. ABSTRACT NLRP3 inflammasome activation drives interleukin (IL)-1β and IL-18 cleavage and secretion and induces pyroptosis. The ketone body β-hydroxybutyrate (BHB), produced during metabolic stress such as caloric insufficiency, has been reported to inhibit this pathway. However, the conditions that enable this effect, and whether it extends to other … Read more
J Immunol. 2026 May 14;215(5):vkag097. doi: 10.1093/jimmun/vkag097. ABSTRACT While the majority of self-reactive CD4+ T cells are deleted or become Foxp3+ regulatory T cells during thymic development, some self-reactive conventional Foxp3- T cells escape to the secondary lymphoid organs early in life. The induction of anergy in such potentially autoreactive T cells has been proposed … Read more
J Immunol. 2026 May 14;215(5):vkag042. doi: 10.1093/jimmun/vkag042. ABSTRACT Nucleolar protein 16 (NOP16) has been increasingly implicated in promoting tumorigenesis and was recently identified as a novel epigenetic regulator. However, its physiological role in nonmalignant cells remains poorly understood. Although NOP16 is ubiquitously expressed across various tissues and cell types, we found it to be preferentially … Read more
J Immunol. 2026 May 14;215(5):vkag068. doi: 10.1093/jimmun/vkag068. ABSTRACT Lung tissue-resident CD8+ T cells facilitate viral clearance and protective immunity to influenza viruses in animal models. Their role during acute human infection is not clear. Here we use bronchoalveolar lavage samples collected from human subjects naturally infected with influenza B virus to show that influenza-specific CD8+ … Read more
J Immunol. 2026 May 14;215(5):vkag100. doi: 10.1093/jimmun/vkag100. ABSTRACT Lupus nephritis (LN), a severe manifestation of systemic lupus erythematosus, is characterized by progressive renal inflammation and tissue injury. To define molecular mechanisms underlying LN progression, we analyzed temporal and spatial transcriptomic profiles in kidneys of lupus-prone New Zealand Black/White F1 mice at 10, 20, and 30 … Read more
J Immunol. 2026 May 14;215(5):vkag090. doi: 10.1093/jimmun/vkag090. ABSTRACT Alveolar macrophages (AMs) are key mediators of lung function and are potential targets for therapies during respiratory infections. TGFβ is an important regulator of AM differentiation and maintenance, but how TGFβ directly modulates the innate immune responses of AMs remains unclear. This shortcoming prevents effective targeting of … Read more
J Immunol. 2026 May 14;215(5):vkag065. doi: 10.1093/jimmun/vkag065. ABSTRACT As the most abundantly farmed freshwater fish species, grass carp (Ctenopharyngodon idella) faces a serious threat from Aeromonas hydrophila infection, underscoring the critical need to understand the genetic basis of disease resistance for selective breeding. This study deciphered the functional association and mechanism between polymorphisms in the … Read more
