The Journal of Immunology

J Immunol. 2025 Apr 25:vkaf028. doi: 10.1093/jimmun/vkaf028. Online ahead of print. ABSTRACT Mannose-binding lectin (MBL) is a vital and versatile component of innate immunity, which plays an essential role in host defense. In mammals, MBL performs multiple functions, including pattern recognition, complement activation, and phagocytosis. Previous studies revealed that OnMBL can promote the opsonophagocytosis of … Read more

J Immunol. 2025 Apr 25:vkae058. doi: 10.1093/jimmun/vkae058. Online ahead of print. ABSTRACT The capacity of Mycobacterium tuberculosis (Mtb) to establish long-term survival is attributed to its ability to subvert host defense mechanisms, especially macrophages. Although Mtb lipids are believed to play a role in this host-pathogen crosstalk, how mycobacterial lipids drive this complex interaction is … Read more

J Immunol. 2025 Apr 25:vkaf074. doi: 10.1093/jimmun/vkaf074. Online ahead of print. ABSTRACT T cell-independent type 2 antigens (TI-2 Ags), such as pneumococcal polysaccharides, elicit weak immunoglobulin G (IgG) responses and are refractive to boosting. Overcoming this challenge is critical for improving vaccines. Previously, we demonstrated a lipid-based adjuvant composed of monophosphoryl lipid A, synthetic cord … Read more

J Immunol. 2025 Apr 25:vkaf057. doi: 10.1093/jimmun/vkaf057. Online ahead of print. ABSTRACT Human metapneumovirus (HMPV) is a leading cause of lower respiratory tract infection in children accounting for 7% of acute care visits and hospitalizations. In particular, neonates and infants have worse outcomes with HMPV infection. The neonatal immune system is regulated to favor anti-inflammatory … Read more

J Immunol. 2025 Apr 24:vkaf068. doi: 10.1093/jimmun/vkaf068. Online ahead of print. ABSTRACT We have designed the first antigen-less pro-vaccine, named 8206, for treating autoimmune diseases. Composed of dexamethasone, rapamycin, and R848 at a mass ratio of 8:20:6, 8206 is a complete tolerogenic adjuvant that acts systemically to form an active vaccine in situ with endogenous … Read more

J Immunol. 2025 Apr 23:vkaf063. doi: 10.1093/jimmun/vkaf063. Online ahead of print. ABSTRACT Human epidermal growth factor receptor 2 (HER2) is highly overexpressed on the surface of breast cancer cells, presenting an attractive target for therapeutic antibodies. Antibody-dependent cellular cytotoxicity (ADCC) is a central mechanism underlying the antitumor activities of anti-HER2 monoclonal antibodies. Here, we engineered … Read more

J Immunol. 2025 Apr 23:vkaf067. doi: 10.1093/jimmun/vkaf067. Online ahead of print. ABSTRACT Regulatory T cells (Tregs) can persist as memory cells (mTregs) in both infectious and non-infectious settings. However, their functional behavior, phenotypic stability, and suppressive properties upon antigen re-exposure remain poorly understood. Emerging evidence suggests that mTregs exhibit enhanced proliferation and suppressive capacity upon … Read more

J Immunol. 2025 Apr 23:vkaf054. doi: 10.1093/jimmun/vkaf054. Online ahead of print. ABSTRACT Autoimmune regulator (AIRE), a transcriptional regulator expressed by medullary thymic epithelial cells, is required for shaping the self-antigen tolerant T cell receptor repertoire. In humans, AIRE mutations caues autoimmune polyglandular syndrome type 1. Among other symptoms, men with autoimmune polyglandular syndrome type 1 … Read more

J Immunol. 2025 Apr 22:vkae066. doi: 10.1093/jimmun/vkae066. Online ahead of print. ABSTRACT Gfi1 is a transcriptional repressor that plays a critical role in hematopoiesis. Gfi1 represses its target genes primarily through interacting with the histone demethylase LSD1 via its SNAG domain. A major function of Gfi1 is to inhibit DNA damage-induced apoptosis through its involvement … Read more

J Immunol. 2025 Apr 22:vkaf072. doi: 10.1093/jimmun/vkaf072. Online ahead of print. ABSTRACT This Pillars of Immunology article is a commentary on 2 pivotal articles that shaped the CD40-CD40L field – “Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM,” written by U. Korthäuer, D. Graf, H.W. Mages, F. Brière, M. Padayachee, S. Malcolm, … Read more