Identifying the master regulator Bcl6 and its archrival Blimp1 for T follicular helper lineage differentiation
J Immunol. 2026 Apr 15;215(4):vkaf357. doi: 10.1093/jimmun/vkaf357. NO ABSTRACT PMID:41984501 | DOI:10.1093/jimmun/vkaf357
The Journal of Immunology
Effectiveness and immunogenicity of a nanoemulsion protein subunit vaccine against Pseudomonas aeruginosa: investigation in diet-induced obese mice
J Immunol. 2026 Mar 17;215(3):vkag052. doi: 10.1093/jimmun/vkag052. ABSTRACT Pseudomonas aeruginosa (Pa) is an opportunistic pathogen threatening individuals with obesity, a condition associated with chronic meta-inflammation and altered immunity. In this study, we evaluate the immunogenicity and protective efficacy of a nanoemulsion-based subunit vaccine (L-PaF/ME/BECC) targeting Pa in a diet-induced obese mouse model. Mice fed a … Read more
Basal phosphorylation of SHIP1 by Lyn suppresses proinflammatory signaling in the absence of a phagocytic synapse
J Immunol. 2026 Mar 17;215(3):vkaf372. doi: 10.1093/jimmun/vkaf372. ABSTRACT Microscale engagement of the hemi-immunoreceptor tyrosine-based activation motif-containing receptor Dectin-1 by fungal particles activates Src-family kinases (SFKs) and Syk, drives second-messenger generation, and induces downstream Erk and Akt signaling and proinflammatory responses in macrophages. To avoid inappropriate activation in the absence of a pathogenic threat, macrophages restrict … Read more
Activation and lineage specific Lag3 expression dynamics in T cells
J Immunol. 2026 Mar 17;215(3):vkag039. doi: 10.1093/jimmun/vkag039. ABSTRACT Co-inhibitory receptors are essential checkpoints to restrain excessive T cell activation. While PD1 and CTLA4 have been extensively studied, the biology of lymphocyte activation gene 3 (Lag3), an emerging target for checkpoint blockade immunotherapy, remains less understood. In this study, we show that Lag3, though largely intracellular … Read more
Low-density neutrophils preferentially infiltrate the skin compared to conventional neutrophils in an experimental psoriasis model
J Immunol. 2026 Mar 17;215(3):vkag016. doi: 10.1093/jimmun/vkag016. ABSTRACT Neutrophils infiltrate lesional skin robustly in individuals with psoriasis. However, their role in chronically inflamed skin-particularly in terms of phenotypic and functional diversity-remains poorly understood. In this study, we investigated the functional potential of 2 distinct circulating neutrophil populations-conventional, polymorphonuclear neutrophils (cNeu) and low-density neutrophils (LDNeu)-to infiltrate … Read more
The value of dysregulated miR-4492/TRAF6 in diagnosis and prognosis for patients with community-acquired pneumonia
J Immunol. 2026 Mar 17;215(3):vkag021. doi: 10.1093/jimmun/vkag021. ABSTRACT Community-acquired pneumonia (CAP) poses a serious threat to the lives of adults. Differentially expressed miRNAs play a crucial regulatory role in CAP. This study aims to explore the diagnostic and prognostic significance of miR-4492 in CAP and its possible mechanism of action with tumor necrosis factor receptor-associated … Read more
Margins of control: ventricular brain borders as architects in central nervous system autoimmunity
J Immunol. 2026 Mar 25;215(S3):vkag023. doi: 10.1093/jimmun/vkag023. ABSTRACT While multiple sclerosis research has long centered on focal demyelinating lesions, it is increasingly recognized that there are distinct, surface-in gradients of diffuse pathology that exist in regions abutting the cerebrospinal fluid (CSF), such as the subpial cortex and periventricular parenchyma. While subpial pathology is thought to … Read more
Skull bone marrow immunity in brain health and disease: mechanisms and models
J Immunol. 2026 Mar 25;215(S3):vkaf267. doi: 10.1093/jimmun/vkaf267. ABSTRACT The skull bone marrow (sBM) is a hematopoietic site intimately connected to the dura mater-the outermost layer of the meninges that surround the central nervous system (CNS)-via vascular channels that enable trafficking of immune cells and sampling of cerebrospinal fluid. sBM-derived cells directly access the dura under … Read more
Vitreoretinal Myeloid Cell Heterogeneity: Diverse Roles in Homeostasis, Immune Surveillance, and Pathophysiology
J Immunol. 2026 Mar 25;215(S3):vkaf321. doi: 10.1093/jimmun/vkaf321. ABSTRACT The retina is a central nervous system tissue with immune-privileged status, protected by the blood-retina barrier and maintained by specialized resident tissue macrophages: microglia, hyalocytes, and perivascular macrophages. These cells exhibit specific ontogeny, spatial localization, and immunologic functions. Each population contributes to homeostasis, phagocytosis, and immunoregulation in … Read more
The dura mater: A hub for immune surveillance at the central nervous system borders
J Immunol. 2026 Mar 25;215(S3):vkaf344. doi: 10.1093/jimmun/vkaf344. ABSTRACT The outer layer of the meninges, the dura mater, forms a critical interface at the border of the central nervous system (CNS). While historically the dura was viewed as a protective physical barrier for the brain and spinal cord, providing structural support for the venous sinuses, more … Read more