J Immunol. 2025 Sep 16:vkaf242. doi: 10.1093/jimmun/vkaf242. Online ahead of print. ABSTRACT Tumor-infiltrating lymphocyte (TIL) therapy is a promising approach, earning U.S. Food and Drug Administration approval in patients with anti-PD-1-resistant melanoma. Extending TIL therapy to patients with cholangiocarcinoma (CCA), an aggressive and largely immune-refractory cancer, is an emerging area of interest. However, cost and … Read more

J Immunol. 2025 Sep 16:vkaf243. doi: 10.1093/jimmun/vkaf243. Online ahead of print. ABSTRACT Disruptor of telomeric silencing 1-like (DOT1L) is an epigenetic regulator that promotes gene expression by methylating lysine 79 on histone H3 and recruits transcription factors to gene targets. DOT1L is also an oncogenic driver in cancers that affect developing lymphocytes, yet how DOT1L … Read more

J Immunol. 2025 Sep 16:vkaf197. doi: 10.1093/jimmun/vkaf197. Online ahead of print. ABSTRACT Pulmonary infections often fail to produce long-lived immune memory and the underlying mechanism(s) for this are unclear. Given the complex interactions between cells within the lung, we predicted intrinsic and extrinsic factors contribute to development of poor memory immune responses. To identify these … Read more

J Immunol. 2025 Sep 16:vkaf253. doi: 10.1093/jimmun/vkaf253. Online ahead of print. ABSTRACT The tumor microenvironment (TME) plays a pivotal role in shaping immune responses and therapeutic outcomes in lung cancer, yet the diversity and functional specialization of tumor-associated macrophages (TAMs) remain poorly resolved. Here, we present a refined classification of TAM subtypes across large cohorts … Read more

J Immunol. 2025 Sep 15:vkaf227. doi: 10.1093/jimmun/vkaf227. Online ahead of print. ABSTRACT Although the interplay between the complement system, platelets, and neutrophils has been considered a major contributor to inflammation and thrombogenicity, little attention has been directed toward understanding their roles in people living with human immunodeficiency virus (PLWH). We quantified and compared expression levels … Read more

J Immunol. 2025 Sep 15:vkaf246. doi: 10.1093/jimmun/vkaf246. Online ahead of print. ABSTRACT Blood coagulation and immune responses have long been considered as discrete processes. However, recent studies have revealed that mammalian platelets play a critical role in immune regulation in addition to their well-established role in hemostasis. This dual functionality suggests an evolutionary link between … Read more

J Immunol. 2025 Sep 15:vkaf200. doi: 10.1093/jimmun/vkaf200. Online ahead of print. ABSTRACT The intestinal mucosa in individuals with chronic human immunodeficiency virus (HIV) infection remains a site of viral persistence and immune dysregulation, even with prolonged suppressive antiretroviral therapy (ART). While biomarkers of mucosal damage and microbial translocation offer valuable correlative insights, the underlying mechanisms … Read more

J Immunol. 2025 Sep 15:vkaf213. doi: 10.1093/jimmun/vkaf213. Online ahead of print. ABSTRACT Osteoarthritis (OA) is characterized by cartilage destruction and immune cell infiltration, of which include myeloid-derived suppressor cells (MDSCs). MDSCs have been shown to expand in obese patients with OA. Therefore, we aimed to investigate the role of obesity on MDSC function in knee … Read more

J Immunol. 2025 Sep 13:vkaf241. doi: 10.1093/jimmun/vkaf241. Online ahead of print. NO ABSTRACT PMID:40971647 | DOI:10.1093/jimmun/vkaf241

J Immunol. 2025 Sep 16:vkaf248. doi: 10.1093/jimmun/vkaf248. Online ahead of print. ABSTRACT Natural killer (NK) cells are pivotal innate lymphoid cells in anti-tumor immunity. However, the contribution of the Y chromosome-encoded epigenetic regulator UTY (also known as KDM6C) to male NK cell development and effector function remains poorly characterized. Here, we demonstrated that conditional deletion … Read more