J Immunol. 2026 Jun 7;215(6):vkag095. doi: 10.1093/jimmun/vkag095. NO ABSTRACT PMID:42309535 | DOI:10.1093/jimmun/vkag095
J Immunol. 2026 Jun 7;215(6):vkag055. doi: 10.1093/jimmun/vkag055. NO ABSTRACT PMID:42309534 | DOI:10.1093/jimmun/vkag055
J Immunol. 2026 Jun 7;215(6):vkag146. doi: 10.1093/jimmun/vkag146. ABSTRACT In inflammatory tissue niches, macrophages encounter intense oxidative stress due to their own production of reactive oxygen and nitrogen species as part of antimicrobial defense. Our findings reveal that inflammatory macrophages deploy distinct, context-dependent redox-protective mechanisms to survive this self-inflicted stress, thereby avoiding ferroptotic cell death. Specifically, … Read more
J Immunol. 2026 Jun 7;215(6):vkag156. doi: 10.1093/jimmun/vkag156. NO ABSTRACT PMID:42300803 | DOI:10.1093/jimmun/vkag156
J Immunol. 2026 Jun 7;215(6):vkag116. doi: 10.1093/jimmun/vkag116. ABSTRACT Interferon-gamma (IFN-γ) is a powerful transactivating signal eliciting hundreds of IFN-stimulated genes (ISGs) in humans to help combat infection. Most ISGs remain uncharacterized, and here we searched for actin-binding candidates that could potentially target intracellular pathogens to block their spread or promote immune cell migration into infected … Read more
J Immunol. 2026 Jun 7;215(6):vkaf379. doi: 10.1093/jimmun/vkaf379. NO ABSTRACT PMID:42295821 | DOI:10.1093/jimmun/vkaf379
J Immunol. 2026 Jun 7;215(6):vkag099. doi: 10.1093/jimmun/vkag099. ABSTRACT Gamma delta (γδ) T cells emerge early during human gestation and are uniquely equipped to protect the fetus and infant following infection, due to their innate-like recognition of conserved molecular ligands. Following congenital cytomegalovirus infection (cCMV), Vδ1 T cells have been shown to expand, differentiate, and upregulate … Read more
J Immunol. 2026 Jun 7;215(6):vkaf377. doi: 10.1093/jimmun/vkaf377. NO ABSTRACT PMID:42295822 | DOI:10.1093/jimmun/vkaf377
J Immunol. 2026 Jun 7;215(6):vkag109. doi: 10.1093/jimmun/vkag109. ABSTRACT Defective resolution of inflammation following sepsis contributes to persistent immune dysfunction and increased morbidity and mortality worldwide. Efficient clearance of apoptotic polymorphonuclear neutrophils (PMNs) by macrophages, a process known as efferocytosis, is essential for resolving inflammation, promoting tissue repair, and restoring immune homeostasis; however, the molecular mechanisms … Read more
J Immunol. 2026 Jun 7;215(6):vkag138. doi: 10.1093/jimmun/vkag138. ABSTRACT Salmonella enterica is a gastrointestinal pathogen that causes a variety of intestinal and systemic clinical disease. Vaccine development for systemic salmonellosis requires a deeper understanding of protective mechanisms and the relative contribution of mucosal and systemic host responses to bacterial elimination. Here, we examined the relative importance … Read more
