The Journal of Immunology

J Immunol. 2026 Jun 7;215(6):vkag159. doi: 10.1093/jimmun/vkag159. ABSTRACT The major capsid protein (MCP), owing to its strong immunogenicity, has emerged as a critical target for largemouth bass ranavirus (LMBV) vaccine development. However, its key antigenic epitopes remain uncharacterized. This study integrated phage display technology with bioinformatics approaches to design a multiepitope vaccine against LMBV. By … Read more

J Immunol. 2026 Jun 7;215(6):vkag149. doi: 10.1093/jimmun/vkag149. ABSTRACT Pathogen-derived RNAs function as pathogen-associated molecular patterns (PAMPs) that activate innate immune responses through pattern recognition receptors (PRRs). While viral RNA is well established as a trigger of antiviral immunity, the identity of bacterial RNA species that function as immunostimulatory ligands and the host PRRs that recognize … Read more

J Immunol. 2026 Jun 7;215(6):vkag114. doi: 10.1093/jimmun/vkag114. ABSTRACT Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is associated with clinical diversity and outcomes ranging from latent TB to active TB with distinct pathophysiologies. However, our understanding of the innate immune mechanisms related to the protection or progression of TB is limited. Among innate immune cells, the … Read more

J Immunol. 2026 Jun 7;215(6):vkag126. doi: 10.1093/jimmun/vkag126. ABSTRACT Germinal centers (GCs) are microanatomical structures in which antigen-specific B cells undergo proliferation, somatic hypermutation, and affinity-based competition to select high-affinity clones that differentiate into memory B cells and plasma cells (PCs). B cell progression through the GC is tightly regulated, and the molecular determinants that modulate … Read more

J Immunol. 2026 Jun 7;215(6):vkag147. doi: 10.1093/jimmun/vkag147. ABSTRACT Cell-to-cell communication is essential for maintaining homeostasis and coordinating complex biological processes in multicellular organisms. Classically, cells communicate using secreted peptides and metabolites and through cell contact-dependent signaling. Emerging studies over the past 20 years indicate that many cell types, including innate immune cells such as macrophages, … Read more

J Immunol. 2026 Jun 7;215(6):vkag118. doi: 10.1093/jimmun/vkag118. ABSTRACT Glycoprotein 130 (GP130) is an archetypal class I cytokine receptor that serves as a shared signalling subunit for a group of cytokines known as interleukin 6 (IL-6)-type cytokines. GP130 does not have an intrinsic kinase activity and relies on Janus kinases (JAK) 1, 2, or Tyrosine kinase … Read more

J Immunol. 2026 Jun 7;215(6):vkaf345. doi: 10.1093/jimmun/vkaf345. NO ABSTRACT PMID:42311113 | DOI:10.1093/jimmun/vkaf345

J Immunol. 2026 Jun 7;215(6):vkag144. doi: 10.1093/jimmun/vkag144. ABSTRACT Neuroblastoma (NB) is the most common extracranial solid tumor in children and remains a major therapeutic challenge in high-risk patients because of frequent recurrence and metastasis. γδT cells are a unique lymphocyte subset with potent antitumor activity and are widely distributed in NB tumors. However, the immunosuppressive … Read more

J Immunol. 2026 Jun 7;215(6):vkag120. doi: 10.1093/jimmun/vkag120. ABSTRACT Checkpoint inhibitors have transformed cancer treatment, yet predicting responses remains challenging. Mitochondrial quality decreases in tumor infiltrating lymphocytes and correlates with impaired antitumor immunity in animal models. Mitochondrial membrane potential (MMP) increases with T cell activation and may also indicate cellular dysfunction. Here, we assessed the MMP … Read more

J Immunol. 2026 Jun 7;215(6):vkag129. doi: 10.1093/jimmun/vkag129. ABSTRACT Despite an effective vaccine against the hepatitis B virus (HBV), there are about 250 million people living with chronic HBV (CHB) worldwide and one million deaths annually. Most children and about 5% of adults exposed to HBV will fail to clear the virus, developing a lifelong infection. … Read more